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张亚平
单位:生命科学学院
地址:云南省昆明市盘龙区青松路21好中科院昆明动物研究所
邮编:650203
电话:86-871-68526519
个人主页: http://sourcedb.kiz.cas.cn/zw/zjrc/201109/t20110916_3350289.html
实验室介绍: http://sourcedb.kiz.cas.cn/zw/zjrc/201109/t20110916_3350289.html
 
个人简历 Personal resume
博士,研究员,中国科学院院士,欧洲科学院外籍院士,发展中国家科学院院士。现任中国科学院副院长、昆明动物研究所“遗传资源与进化”国家重点实验室学术委员会主任和分子进化与基因组多样性学科组负责人;兼任中国遗传学会理事长、中国动物学会副理事长,国际重要刊物Genome Biol Evol 副主编、Anim Genet、Sci Rep、J Hered 编委。推动了国际生命条形码计划和国际“千犬基因组计划”。同时通过推动中国科学院西南家猪分子育种基地的建设将畜禽进化基因组的研究成果应用于家猪分子育种实践并进行产业转化与推广。

  在建立具有国际影响的人群和动物DNA库的基础上,主要从分子水平研究生物多样性的演化及机制,澄清了灵长类、食肉类、两栖爬行类等动物类群系统与演化中的一些重要问题。揭示了东亚人群进化的一些规律和一些民族的演化历程。系统地研究了野生动物和家养动物的遗传多样性,发现遗传多样性贫乏与物种濒危之间没有必然的对应关系;确定了家犬的东亚起源,证明东亚是家养动物驯化的重要区域。对自然选择和人工选择作用下基因组进化的研究,揭示了一些重要的动物适应进化和畜禽经济性状形成的遗传机制。近5年来,在Science,Nature,PNAS,PLos Genetics等国际刊物发表SCI文章150余篇。先后获国家自然科学二等奖、长江学者成就一等奖、云南省科技突出贡献奖、何梁何利基金科学与技术进步奖等国家和省部级科技奖励20余项。由于在生物多样性研究领域的突出贡献,获国际重要奖项“生物多样性领导奖”,成为亚洲地区唯一的获奖人。
 
研究方向 Research direction
1、基因组多样性与分子进化
2、家养动物起源驯化与人工选择的基因组进化机制
3、人和动物高原适应的分子机制
 
招生信息 Enrollment information
  
 
论文专著 The monograph
1) Comment on "Rconstructing the origin of Anadman islanders" - Science - 2006 - 311:470(2006)
2) The unusual adaptive expansion of pancreatic ribonuclease gene in Carnivora - Mol Biol Evol - 2006 - 23:2326-35(2006)
3) Updating the East Asian mtDNA phylogeny:a prerequisite for the identification of pathogenic mutations - Hum Mol Genet - 2006 - 15:2076-86(2006)
4) Molecular evolution study in China:progress and future promise - Phil.Trans.R.Soc.B - 2007 - doi:10.1098/rstb.(2007)
5) Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau - PNAS - 2009 - 106(50):21230-35(2009)
6) Adaptive evolution of energy metabolism genes and the origin of flight in bats - PNAS - 2010 - 107(19):8666-71(2010)
7) Spiny frogs (Paini) illuminate the history of the Himalayan region and Southeast Asia - PNAS - 2010 - 107(31):13765-70(2010)
8) Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication - Nature - 2010 - 464:898-U109(2010)
9) The sequence and de novo assembly of the giant panda genome - Nature - 2010 - 463:311-317(2010)
10) China, India, and the Environment - Science - 2010 - 327(5972):1457-59(2010)
11) Phylogenetic Utility of Nuclear Introns in Interfamilial Relationships of Caniformia (Order Carnivora) - Systematic Biology - 2011 - 60(2):175-87(2011)
12) De Novo Origin of Human Protein-Coding Genes - Plos Genet - 2011 - 7(11)(2011)
13) Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region - Mol Biol Evol - 2011 - 28(1):513-22(2011)
14) Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster - PNAS - 2011 - 108(38):15914-19(2011)
15) Difference in selection driver 36. Positive selection on the gene RNASEL: correlation between patterns of evolution and function - Mol Biol Evol - 2012 - 29(10):3161-68(2012)
16) Difference in selection driver Olfactory receptor genes in different directions in dogs and wolf - Mol Biol Evol - 2012 - 29(11):3475-84(2012)
17) Genetic Adaptation of the Hypoxia-Inducible Factor Pathway to Oxygen Pressure among Eurasian Human Populations - Mol Biol Evol - 2012 - 29(11):3359-70(2012)
18) Parallel Evolution of Auditory Genes for Echolocation in Bats and Toothed Whales - PLos Genet - 2012 - 8(6):e1002788(2012)
19) Diversification of rhacophorid frogs provides evidence for accelerated faunal exchange between India and Eurasia during the Oligocene - PNAS - 2013 - 110:3441-46(2013)
20) Chicken domestication: an updated perspective based on mitochondrial genomes - Heredity - 2013 - 110:277-82(2013)
21) The genomics of selection in dogs and the parallel evolution between dogs and humans - Nat Commun - 2013 - 4:1860(2013)
22) Artificial selection on brain-expressed genes during the domestication of dog - Mol Biol Evol - 2013 - 30:1867-76(2013)
23) Draft genome sequence of the Tibetan antelope - Nat Commun - 2013 - 4:1858(2013)
24) Population Variation Revealed High-Altitude Adaptation of Tibetan Mastiffs - Mol Biol Evol - 2014 - 31(5):1200-05(2014)
25) Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne - Nat Commun - 2014 - 5:2870(2014)
26) Caveats about interpretation of ancient chicken mtDNAs from northern China - PNAS - 2015 - 112(16):E1970-71(2015)
27) Genomic analyses reveal potential independent adaptation to high altitude in Tibetan chickens - Mol Biol Evol - 2015 - 32:1880-89(2015)
28) DoGSD: the dog and wolf genome SNP database - Nucleic Acids Res - 2015 - 43:D777-83(2015)
29) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation - Nat Genet - 2016 - 48(8):947-52(2016)
30) Olfactory genes in Tibetan wild boar - Nat Genet - 2016 - 48(9):972-73(2016)
31) Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication - Cell Res - 2016 - 26:556-73(2016)
32) Out of southern East Asia: the natural history of domestic dogs across the world - Cell Res - 2016 - 26:21-33(2016)
33) Questioning the evidence for a Central Asian domestication origin of dogs - PNAS - 2016 - 113:e2554(2016)
 
报考意向 Ambition
 
 
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