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李志远
单位:生命科学学院
地址:广州市萝岗区科学城开源大道190号
邮编:510530
电话:+86-20-32015241
个人主页: http://lizy.gibh.ac.cn/
实验室介绍:
 
个人简历 Personal resume
李志远,男,教授,研究员,博士生导师,中国科学院广州生物医药与健康研究院华南干细胞与再生医学研究所PI。毕业于湘雅医学院(现中南大学),在日本获得博士学位后,在美国著名的Vanderbite大学从事博士后研究,后就职于St. Louis大学,进入助理教授阶层,2008年底回国。回国后在SCI收录期刊上发表论文60多篇,专著(章、节)7部,申请专利 26项,其中有12项已授权;现承担"973"、国家自然基金、广东省、佛山市等10多项课题,总经费3000万以上,担任国际期刊Scientific Reports (Nature Publishing Group)、Journal of stem cells and clinical practice、Journal of Neurorestoratology杂志编委,国际离子通道论坛科学顾问委员。
 
研究方向 Research direction
1、干细胞的基础研究及临床应用
2、由iPS分化而成的神经元离子通道特征研究
3、P2X 离子通道的功能研究
 
招生信息 Enrollment information
一、所需生源知识背景   

1. 神经生物学、生物化学、分子生物学、遗传学等相关领域,专业知识扎实,熟练掌握分子和细胞生物学相关实验技术。

2.具有良好的英文文献阅读、写作和口头表达能力,在相关领域作为第一作者发表过SCI论文,已发表过较高水平的研究论文者优先考虑。

3. 对于科学研究具有较强的兴趣和热情,具有较强的独立工作能力,诚实、富有责任心和团队合作精神。

二、学生待遇   

提供良好的科研工作环境,充分考虑学生的未来发展和职业规划,支持申报各类基金和科研项目,保障参加国内外高水平学术会议及在国际著名大学学习交流的机会。   

三、联系方式   

有意者请将材料发至邮箱:li_zhiyuan@gibh.ac.cn,邮件标题注明:博士生招生+本人姓名。  

李志远教授个人主页:http://lizy.gibh.ac.cn/
 
论文专著 The monograph
1) Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3 - Traffic - 2016 - 17(5)
2) CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation - Transl Psychiatry - 2015 - 6
3) Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in human hepatoma cells - Free Radic Biol Med - 2015 - 89
4) Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion - Neural Regen Res - 2015 - 10(9)
5) Prenatal genesis of layer II doublecortin expressing neurons in neonatal and young adult guinea pig cerebral cortex - Front Neuroanat - 2015 - 9
6) Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells - CNS Neurosci Ther. - 2015 - 21(7)
7) Roles of the lateral fenestration residues of the P2X₄ receptor that contribute to the channel function and the deactivation effect of ivermectin - Purinergic Signal - 2015 - 11(2)
8) Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats - BMC Neurosci - 2015 - 16
9) Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex - Front Neuroanat - 2015 - 9
10) Vitamin E isomer δ-tocopherol enhances the efficiency of neural stem cell differentiation via L-type calcium channel - Neurosci Lett - 2015 - 585C
11) Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement - Neurosci Lett - 2014 - 582
12) Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats - Adv Alzheimer Dis - 2014 - 3(2)
13) Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms - Biol Psychiatry - 2014 - 76(10)
14) Involvement of ectodomain Leu 214 in ATP binding and channel desensitization of the P2X4 receptor - Biochemistry. - 2014 - 53(18)
15) Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique - Scientific Reports - 2014 - 4
16) Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide - Eur J Pharmacol - 2014 - 737
17) Principles and properties of ion flow in P2X receptors - Front Cell Neurosci - 2014 - 8
18) Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptor - PLoS One - 2013 - 8(8)
19) New strategy for high throughput screening of anti-influenza virus M2 ion channel inhibitors - Curr Pharm Des - 2013 - 19(28)
20) Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride - Toxicol Appl Pharmacol - 2013 - 267(2)
21) Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle - Stem Cell Res - 2013 - 11(1)
22) Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10 - Sci Rep - 2013 - 3
23) Experimental epidural hematoma causes cerebral infarction and activates neocortical glial and neuronal genesis in adult guinea pigs - J Neurosci Res - 2013 - 91(2)
24) Somal and dendritic development of human CA3 pyramidal neurons from midgestation to middle childhood: a quantitative Golgi study - Anat Rec (Hoboken) - 2013 - 296(1)
25) Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells - Stem Cell Res - 2013 - 10(3)
26) Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors - Antiviral Res - 2012 - 96(2)
27) A comparison of the performance and application differences between manual and automated patch-clamp techniques - Curr Chem Genomics - 2012 - 6
28) Anterior cingulate cortical lesion attenuates food foraging in rats - Brain Res Bull - 2012 - 88(6)
29) Lipopolysaccharide induces paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning-memory deficit in rats - Neuroscience - 2012 - 209
30) Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization - Eur J Med Chem - 2012 - 52
31) Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes - Hum Mol Genet - 2012 - 21(1)
32) Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion - Purinergic Signal - 2012 - 8(2)
33) Molecular mechanism of ATP binding and ion channel activation in P2X receptors - Nature - 2012 - 485(7397)
34) P2X7 receptor positively regulates MyD88 dependent NF-kB activation[J].Cytokine,2011,55(2):229-236 - - 2011 - 55(2)
35) Identification of hits as matrix-2 protein inhibitors through the focused screening of a small primary amine library - J Med Chem - 2010 - 53(9)
36) Ion channels as antivirus targets[J].Virol Sin.2010.25(4):267-280 - - 2010 - 25(4)
37) Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells - J Biol Chem - 2010 - 285(15)
38) A Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A - Chinese J Chem - 2010 -
39) The effects of exercise-induced fatigue on acetylcholinesterase expression and activity at rat neuromuscular junctions - Acta Histochem Cytochem - 2009 - 42(5)
40) An agarose-gel based method for transporting cell lines - Curr Chem Genomics - 2009 - 3
41) Formalin-induced increase in P2X(3) receptor expression in dorsal root ganglia: implications for nociception - Clin Exp Pharmacol Physiol - 2009 - 36(8)
42) P2X Receptors - Encyclopedia of Neuroscience - 2008 - 7
43) Potential therapeutic targets for ATP-gated P2X receptor ion channels - Assay Drug Dev Technol. - 2008 - 6(2)
44) On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptor - J Biol Chem - 2008 - 283(8)
45) P2X Receptors - Encyclopedia of Neuroscience - 2007 -
46) Biophysics of P2X receptors - Pflugers Arch - 2006 - 452(5)
47) Gain and loss of channel function by alanine substitutions in the transmembrane segments of the rat ATP-gated P2X2 receptor - J Neurosci - 2004 - 24(33)
48) P2X Receptor - Encyclopedia of Neuroscience - 2003 - 876-890
49) Molecular characterization of the zebrafish P2X receptor subunit gene family - Neuroscience - 2003 - 121(4)
50) Involvement of Ca2+ -activated K+ channels in ginsenosides-induced aortic relaxation in rats - J Cardiovasc Pharmacol - 2001 - 37(1)
51) K(Ca) channel-opening activity of Ginkgo Biloba extracts and ginsenosides in cultured endothelial cells - Clin Exp Pharmacol Physiol - 2001 - 28(5-6)
52) Induction of inducible nitric oxide synthase by ginsenosides in cultured porcine endothelial cells - Life Sci - 2000 - 67(24)
53) Estrogen modulates a large conductance chloride channel in cultured porcine aortic endothelial cells - J Cardiovasc Pharmacol - 2000 - 35(3)
54) Expression of endothelin-1 in macrophages and mast cells in hyperplastic human tonsils - FEBS Lett. - 1999 - 457(3)
55) Effect of ischemia-reperfusion injury on the expression of nitric oxide synthase in rat retina - Hunan Yi Ke Da Xue Xue Bao. - 1999 - 24(5)
56) Cardiovascular protective effects and NO-mediated cerebrovasorelaxant effects of extract of ginkgo biloba leaves - Zhonghua Yi Xue Za Zhi. - 1998 - 78(9)
57) The influence of pressure on human lamina cribrosa cell and its collagen synthesis - Zhonghua Yan Ke Za Zhi. - 1998 - 34(1)
58) Effects of endotoxemia on the nitric oxide synthase activaties in rat myocardium - - 1996 - 24(3)
59) Immunohistochemical study of C-fos expression in the process of myocardium hypertrophy in culture - Chinese J Histochem Cytochem - 1996 - 5(1)
60) Histochemical distribution of nitric oxide synthase in rabbit lung and effect of ischemia on its activity - Bull.of Hengyang Med Coll - 1996 - 24(3)
61) The study of C-myc and P53 in cardiovascular diseases - Adv Cardiovas Dis - 1996 - 17(5)
62) The gene expression of P53 and C-myc in the cultured of hypertrophy of neonatal myocardial cells of rats-in situ hybridization study - J Histochem Cytochem - 1994 - 3(6)
63) Chloride channels in vascular endothelial cells- electrophysiological characters and functions - Life Sci - - 5(6)
 
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