访问量:11548
 
蔡刚
单位:生命科学学院
地址:安徽省合肥市蜀山区黄山路443号中国科学技术大学西区生命学院8楼
邮编:230037
电话:86-551-63603802
个人主页: http://cailab.ustc.edu.cn
实验室介绍:
 
个人简历 Personal resume
    蔡刚,中国科学技术大学生命科学学院教授,博士生导师,2011年入选教育部新世纪优秀人才支持计划,2012年获得国家自然科学基金委优秀青年基金,2017年获得杰出研究校长奖,2019入选万人计划领军人才,获得药明康德生命化学研究奖。主要采用冷冻电镜(cryo-EM)解析基因组稳定性和染色质结构调控的分子机制,取得了一系列具有创新性的研究成果。近五年主要学术成绩为解析ATM和ATR激酶首个高分辨率冷冻电镜结构,揭示ATM/ATR激酶活性严谨调控和活化的分子机制;首次清晰解析转录中介体和乙酰化NuA4/Tip60复合体的模块和亚基架构。近五年发表通讯作者论文11篇,包括Science 2017,Nature Communications 2016,2018,Cell Research,2014等;多次在国内外会议及科研单位作学术报告并应邀为Current Opinion in Structural Biology、Nature Communications、Cell Research等多种国际、国内学术刊物审稿。
 
研究方向 Research direction
1、冷冻电镜三维重构
2、基因组稳定性
3、染色质结构调控
 
招生信息 Enrollment information
需要具备生物化学,分子生物学,细胞生物学等系统知识;尤其欢迎有计算背景的考生。本实验室将提供系统全面的蛋白质及复合体高效纯化,冷冻电镜三维重构,和蛋白质-蛋白质,蛋白质-核酸相互作用研究的训练,使学生掌握冷冻电镜结构功能研究的前沿技术和方法。
 
论文专著 The monograph Researcher ID
1) 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP - Science - 2017 - 2017.12
2) Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex - Nature Communications - 2018 - 2018
3) Structure of the intact ATM/Tel1 kinase - Nature Communications - 2016 - 2016
4) Redefining the modular organization of the core Mediator complex - Cell Research - 2014 - 2014.07
5) Architecture of SWI/SNF Chromatin Remodeling Complex - Protein & Cell - 2018 - 2018
6) Structural flexibility and functional interaction of Mediator Cdk8 module(SCI收录) - Protein Cell - 2013 - 4, 911-920
7) AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus - International Journal of Medical Microbiology - 2017 - 2017.06
8) Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations - PLos One - 2015 - 2015
9) Interaction of the mediator head module with RNA polymerase II. - Structure - 2012 - 2012
10) Crystal structure of DnaT84–153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode - Nucleic Acids Res - 2014 - 2014
11) Mediator head module structure and functional interactions. (SCI 收录) - Nat Struct Mol Biol - (2010) - 17, 273-9
12) Architecture of the Mediator head module - Nature - 2011 - 475, 240-3
13) A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes (SCI收录) - Mol Cell Biol. - (2010) - 30, 5502-13
14) State-of-The-Art of Single Particle EM. - Acta Biophysica Sinica - (2010) - 26, 560-69
15) Mediator structural conservation and implications for the regulation mechanism (SCI收录) - Structure - (2009) - 17, 559-67
16) Cloning, sequence analysis and expression of the gene encoding a novel wide-spectrum amidase belonging to the amidase signature superfamily from Achromobacter xylosoxidans (SCI收录) - FEMS Microbiol Lett - 2005 - 249, 15-21
17) Cloning, overexpression, and characterization of a novel thermostable penicillin G acylase from Achromobacter xylosoxidans: probing the molecular basis for its high thermostability. - Appl Environ Microbiol - (2004) - 70, 2764-70
18) Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes. - Nat Struct Mol Biol - 2011 - 18, 1196-203
19) Structural basis for receptor recognition and pore formation of a zebrafish aerolysin‐like protein - EMBO Reports - 2016 - 2016
20) Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin - Journal of Structural Biology - 2014 - 2014
 
报考意向 Ambition
 
 
COPYRIGHT 2007 中国科学技术大学研究生院、校学位办 All Rights Reserved 地址:安徽省合肥市金寨路96号 邮编:230026。
TEL:+86-551-63602928 FAX:+86-551-63602179 E-mail:gradschl@ustc.edu.cn