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吴缅
单位:生命科学学院
地址:安徽合肥中国科大生命科学学院
邮编:230027
电话:+86-551-3606264
个人主页: http://dsxt.ustc.edu.cn/zj_js.asp?zzid=309
实验室介绍:
 
个人简历 Personal resume
吴  缅,教授,博士生导师。中科院百人计划引进人才。1982年本科毕业于南京师范大学生物系,1984年获美国哥伦比亚大学生物化学硕士,1988年获哥伦比亚大学分子生物学博士,1988-1990美国哈佛大学细胞发育系的博士后。1991-1998新加坡大学及新加坡中央医院神经内科任助理教授及高级研究员。2000年至今,中国科学技术大学生命科学学院教授。在SCI杂志上共发表了论文50多篇,被国际同行引用超过800次。Journal of Molecular and Cell Biology副主编,Acta Biochimica et Biophysica Sinica编委,科学通报编委。
 
研究方向 Research direction
1、p53与代谢
2、非编码RNA
3、iPS诱导
 
招生信息 Enrollment information
仅招收硕博连读生
考试科目:英语/细胞生物学/生化与分子生物
 
论文专著 The monograph
1) p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. - Nature Cell Biology - 201103 - 2011年第三期
2) E2F1 inhibits MDM2 expression in a p53-dependent manner. - Cell Signal - 201101 - 2011年第一期
3) NPM/B23 inhibits Eg5-mediated microtubules depolymerization via inactivating its ATPase activity - J Biol Chem. - 201006 - 2010年第二十五期
4) B23 acts as a nucleolar stress sensor and promotes cell survival via its dynamicinteraction with hnRNPU and hnRNPA1. - Oncogene - 201001 - online publication
5) ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation - Oncogene - 201002 - 4;29(5):711-22
6) The Pirh2-Keratin 8/18 interaction modulates the cellular distribution of mitochondria and UV-induced apoptosis. - Cell Death Differ - 200906 - 16(6):826-37
7) Suppression of p53 activity by Siva1 - Cell Death & Differ - 200911 - 16, 1493-1504
8) E2F1 represses beta-catenin/TCF activity by direct upregulation of Siah1. - J Cell Mol Med - 2009 - Vol 13, Issue 8b, 1719-1727
9) Multiple Roles for Nuclear Localization Signal (NLS, aa 442-472) of Receptor-Interacting Protein 3 (RIP3). - Biochem Biophys Res Commun - 200808 - 8;372(4):850-5
10) Noxa/Mcl-l balance regullates susceptibility of cells to camptothecin-induced apoptosis. - Neoplasia - 200710 - 9(10):871-81
11) Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. - Cell Signal - 200706 - 19(10):2056-67
12) Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiq uitinate p53. - The EMBO J - 200707 - 11;26(13):3062-74
13) Siah-1S, a novel splice variant of Siah-l(seven in absentia homolog),counteracts Siah-l-mediated. - Oncogene - 200709 - 20;26(43):6319-31
14) Death effector domain DEDa,a self-cleaved product of Caspas e-8/Mch5,translocates to the nucleus by binding to ERK1/2 and up-regulates procaspase-8 express on via a p53-dependent mechanism. - The EMBO J - 200702 - 26,1068-1080
15) p53 and Bad: remote strangers become close friends. - Cell Research - 200704 - 17(4):283-5
16) The Bad Guy Cooperates with Good Cop p53:Bad Is Transcriptionally Up-Regulated by p53- and Forms a Bad/p53 Complex at the Mitochondria to Induce Apoptosis. - Mol Cell Biol - 200612 - 26(23)9071-9083
17) Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. - Cell Death Differ - 200612 - 13(12):2079-88
18) Novel link between E2F1 and Smac/DIABLO:proap optotic Smac/DIABLO is transcriptionally upregulated by E2F1. - Nucleic Acids Res - 200604 - 14;34(7):2046-55
19) Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703 - Biochem Biophys Res Commun. - 200609 - 2006年第三期
20) Suppression of tumor growth using a recombinant adenoviral vector carrying the dominant-negative mutant gene Survivin-D53A in a nude mice model - Cancer Gene Ther. - 200608 - 2006年第八期
21) Puma*Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1. - Oncogene. - 200511 - 2005第四十八期
22) Identification of a novel nucleolar Iocalization signal and a degradation signal in Survivin-deltaEx3:a potential lind between nucleolus and protein degradation - Oncogene - 200504 - 14;24 (16):2723-34
23) RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis - Biochem Biophys Res Commun. - 200501 - 2005年第一期
24) Nucleocytoplasmic Shuttling of RIP3:Identification of Novel Nuclear Export and Import Signals in RIP3. - J.Biol.Chem - 200409 - 279:38820-38829
25) A Single Amino Acid Change (ASP53 Ala53)Converts Survivin from Anti-apoptotic to pro-apoptotic - Mol.Biol.Ceil - 200403 - 15(3):1287-96
26) p53-dependent apoptotic mechanism of a new designer bimetallic compound Tri-pheny tin benzimid920lethio copper chloride(TPT-CuCl2):Invivo studies in Wistar rats as well as in vhro studies in human cer - J.Phurmacol Exp Ther - 200410 - 311:22-33
27) Direct interaction between surivin and Smac is essential for the anti-apoptotic activity of survivin during Taxol-induced apoptosis - J.Biol.Chem - 200306 - 278(25):23130-40
28) Triphenyl tin benzimidazolethiol, a novel antitumor agent, induces mitochondrial-mediated apoptosis in human cervical cancer cells via suppression of HPV-18 encoded E6. - J Biochem (Tokyo) - 200310 - 134(4):521-8
29) Etoposide upregulates Bax enhancing tumor necrosis factor-related apoptosis-inducing ligand mediated apoptosis in Human hepatocellular carcinoma cell line OGY.7703 - Eur.J.Blochem. - 200307 - (270)2721-2731
30) Bcl rambo bera a special splicing variant with an insertion of Atu-like cassette,promotes etoposide-and Taxol-induced cell death. - FEBS Letters - 200301 - 534:61-68
31) Endostatin: Its antiagiogenic and therapeutic implications. - Method Find. Exp. Clin. Pharmacol. - 2003 - 2003第三期
32) HIV-1 TAT mediated protein transduction and subcellular localization using novel expression vectors. - FEBS Letter - 200212 - 532:36-44
 
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