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熊伟
单位:生命科学学院
地址:安徽合肥市黄山路中国科技大学西区新科技楼
邮编:230026
电话:0551-63601736
个人主页: https://biox.ustc.edu.cn/2014/0224/c692a340190/page.htm
实验室介绍: http://x-lab.ustc.edu.cn/
 
个人简历 Personal resume
中国科学技术大学生命科学学院副院长、教授、博士生导师,合肥综合性国家科学中心人工智能研究院副院长,中科院脑科学与智能技术卓越创新中心成员。北京大学学士及博士学位,美国国立卫生研究院博士后。从事神经生物学及神经化学领域的相关科学研究,研究方向包括:脑衰老与神经退行性疾病、神经环路与神经代谢调控、新型质谱技术研发等。在Cell、Nature Methods、Nature Communications、PNAS、Cell Reports、FASEB J、JBC等国际期刊发表多篇通讯作者论文。工作入选2018年度“中国生命科学十大进展”。主持过多项国家级科研项目,包括:基金委重点项目、科技部“十三五”重点研发计划(课题组长)、中科院B类先导科技专项(课题组长)、863青年科学家等。曾获科技部“中青年科技创新领军人才”、“万人计划”科技创新领军人才、中科院优秀导师、中国科学技术大学杰出研究校长奖、唐立新优秀学者奖等。
 
研究方向 Research direction
1、脑衰老与神经退行性疾病的发生发展机制
2、新型质谱技术研发及其在神经科学中的应用
3、感知觉的中枢神经环路和调控机制
 
招生信息 Enrollment information
 招生招聘:
实验室招聘分析化学、分子生物学、生物信息学等相关背景的co-PI、博士后和实验员,待遇从优。同时欢迎本科实习生和报考研究生。
 
联系方式:wxiong@ustc.edu.cn
联系电话:0551-63601736  
 
论文专著 The monograph
1) Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain - Cell - 2018 - 173: 1716-1727
2) Metabolomic profiling of single enlarged lysosomes - Nature Methods - 2021 - 18(7):788-798
3) Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission - Nature Communications - 2021 - 12(1):297
4) Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry - PNAS - 2017 - 114: 2586-2591
5) Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction. - Cell Reports - 2020 - 30(12): 4209-4219
6) Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization - Analytical Chemistry - 2019 - 91(4): 2719-2726
7)  Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry - Analytical Chemistry - 2019 - 91(10): 6616-6623
8) Membrane cholesterol dependence of cannabinoid modulation of glycine receptor - FASEB J - 2020 - 34: 10920-10930
9) Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors - iScience - 2019 - 19: 634-646
10) The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. - The Journal of Biological Chemistry - 2020 - 295: 138-145
11) Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice - Molecular Brain - 2021 - 14(1): 41
12) Cholesterol regulates cannabinoid analgesia through glycine receptors. - Neuropharmacology - 2020 - 177: 108242
13) Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. - Neuropharmacology - 2018 - 133: 224-232
14) Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease - Nature Neuroscience - 2014 - 17: 232-239
15) Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. - Nature Chemical Biology - 2011 - 7: 296-303
16) Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors - Journal of Experimental Medicine - 2012 - 209 (6): 1121-1134
17) A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. - Journal of Neuroscience - 2012 - 32 (15): 5200-5208
18) Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization. - Molecular Pharmacology - 2008 - 73:314-322
19) Loss of metabotropic glutamate receptor 2 escalates alcohol consumption - PNAS - 2013 - 110(42):16963-8
20) Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. - Neuroscience - 2011 - 184: 28-37
21) Receptor trafficking induced by μ-opioid-receptor phosphorylation. - Neuroscience & Biobehavioral Review - 2009 - 33: 1192-1197
22) Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice. - Anesthesiology - 2012 - 17(4):765-71
23) Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols. - Journal of Pharmacology and Experimental Therapeutics - 2012 - 340: 304-316
24) Involvement of endogenous cholecystokinin in morphine tolerance in the nucleus accumbens of rats. - Behavioural Brain Research - 2006 - 173:116-121
25) Involvements of mu- and kappa- opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats. - Neuroscience Letters - 2006 - 399: 167-170
 
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