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宋晓元
单位:生命科学学院
地址:安徽省合肥市黄山路443号中国科学技术大学生命科学院
邮编:230026
电话:63607752
个人主页: http://biox.ustc.edu.cn/szdw/zzbqnqrjh/201301/t20130104_146413.html
实验室介绍: https://biox.ustc.edu.cn/2013/0104/c699a11014/page.htm
 
个人简历 Personal resume
    ,教授,博士生导师。毕业于北京师范大学生物系,1996年和1999年分别获得学士和硕士学位。2006年在美国罗彻斯特大学生物系取得分子、细胞和发育生物学博士学位。2006-2012年在加州大学圣地亚哥分校进行博士后研究,期间获得癌症研究所博士后奖学金资助。2012年12月加入中国科学技术大学生命科学学院。多年来一直从事基因转录调控、长链非编码RNA(lncRNA)、染色质间相互作用等相关研究,在Genes & Dev. 、Mol Cell Biol. 、Nature、PNAS等学术期刊上发表了系列文章。
 
研究方向 Research direction
1、研究由lncRNA和三维基因组结构所组成的三维转录调控在脑衰老中的作用
2、研究lncRNA和染色质相互作用在精子发生过程中的转录调控作用
3、研究减数分裂相关特定基因的功能及其分子机制
 
招生信息 Enrollment information
   
 
论文专著 The monograph Researcher ID
1) Three-dimensional Regulation of Transcription - Protein & Cell. - 2015 - 2015 Feb 12.
2) Enhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program. - PNAS. - 2015 - 2015, 112(5): 1380-1385
3) Trans-Recruitment of a DNA-Binding Transcription Factor Complex Is Required for Activation of ERα-bound Enhancers. - Cell. - 2014 - 2014, 159(2):358-73.
4) Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. - Nature. - 2013 - 2013, 498(7455):516-20.
5) Promoter-Associated Noncoding RNA from the CCND1 promoter. - Methods in Molecular Biology. - 2012 - 2012, 809:609-22.
6) The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation - GENES & DEVELOPMENT - 2012 - 2012, 26(6):615-29.
7) 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response - NATURE - 2011 - 2011, 470(7333):264-8.
8) The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs - COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY - 2011 - 2011 3(1):a003756.
9)  Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription - NATURE - 2008 - 2008, 454(7200):126-30.
10) Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila - MOLECULAR AND CELLULAR BIOLOGY - 2007 - 2007, 27(7):2648-60.
11) Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation - MOLECULAR AND CELLULAR BIOLOGY - 2007 - 2007, 27(5):1925-33.
12) The H1 Phosphorylation State Regulates Expression of CDC2 and Other Genes in Response to Starvation in Tetrahymena thermophila. - Mol Cell Biol. - 2005 - 2005, 25(10):3914-22.
13) Elimination of foreign DNA during somatic differentiation in Tetrahymena thermophila shows position effect and is dosage dependent. - Eukaryot Cell. - 2005 - 2005, 4(2):421-31.
14) A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. - PNAS. - 2002 - 2002, 99(6):3734-9.
 
报考意向 Ambition
 
 
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