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张智
单位:生命科学学院
地址:合肥市黄山路443号生命科学学院
邮编:230026
电话:63602715
个人主页: https://biox.ustc.edu.cn/2012/1105/c692a340192/page.htm
实验室介绍:
 
个人简历 Personal resume
中国科学技术大学生命科学学院教授、博士生导师,科技部青年973首席科学家。2001年毕业于安徽大学并获生物化学学士学位,2008年获中国科学技术大学神经生物学博士学位,2008-2012年在美国德克萨斯大学MD Anderson cancer center从事博士后工作,主要研究阿片类药物的镇痛和疼痛产生的表观遗传学机制,相关研究成果发表在Nature Medicine, Journal of Neuroscience, Cerebral Cortex和FASEB J等学术期刊上,其中两篇论文分别被Nature Reviews Neuroscience和Nature Reviews Drug Discovery杂志Highlight。2012年10月起任中国科学技术大学生命科学学院教授。
 
研究方向 Research direction
1、慢性疼痛
2、抑郁症
 
招生信息 Enrollment information
   
 
论文专著 The monograph
1) A neural circuit for comorbid depressive symptoms in chronic pain - NATURE NEUROSCIENCE - - 1097-6256
2) A basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior - PNAS - 2019 -
3) A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain - PAIN - - 0304-3959
4) Persistent inflammation-induced upregulation of BDNF promotes synaptic delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor GluA1 subunits in descending pain modulatory circuits - J. Biol. Chem. - 2014 -
5) MeCP2 repression of G9a in regulation of pain and morphine reward - The Journal of Neuroscience - 2014 -
6) Epigenetic suppression of GAD65 expression mediates persistent pain - Nature Medicine - 2011 -
7) Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation - Molecular Pharmacology - 2013 -
8) Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception - Molecular Pharmacology - 2012 -
9) Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval - Cerebral Cortex - 2008 -
10) Synaptic mechanism for functional synergism between delta- and mu-opioid receptors - Journal of Neuroscience - 2010 -
11) Nerve growth factor-regulated emergence of functional delta-opioid receptors - Journal of Neuroscience - 2010 -
12) Persistent Pain Facilitates Response to Morphine Reward by Downregulation of Central Amygdala GABAergic Function - Neuropsychopharmacology - 2014 -
13) Central Amygdala GluA1 Facilitates Associative Learning of Opioid Reward - Journal of Neuroscience - 2013 -
 
报考意向 Ambition
 
 
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