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刘强
单位:中国科学技术大学
地址:安徽省合肥市黄山路443号,中国科学技术大学生命科学学院344室
邮编:230027
电话:055163601179
个人主页: http://biox.ustc.edu.cn/szdw/zzbqnqrjh/201302/t20130201_147277.html
实验室介绍:
 
个人简历 Personal resume
  2005年毕业于中科院生物物理所,获博士学位。曾在美国宾夕法尼亚大学,休斯医学研究所从事博士后研究,后回国。
  主要研究方向:
   1.学习记忆的分子神经生物学机制。
   2.中枢神经系统的能量代谢调控
   3.中枢神经系统脂代谢调控与肥胖糖尿病的关系;
   4.脂代谢在神经退行性疾病以及衰老中的分子细胞机制;
   5.非编码RNA在中枢神经系统中的作用,包括学习记忆,能量代谢等过程。
 
研究方向 Research direction
1、学习记忆,神经退行性疾病以及非编码RNA在神经系统中的作用
2、大脑代谢调控
3、脑衰老与神经退行性疾病
 
招生信息 Enrollment information
  
 
论文专著 The monograph
1) .Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. - PLoS Biology - 2011 -
2) U1 snRNP Determines mRNA Length and Regulates Isoform Expression. - Cell - 2012 -
3) Lipoprotein receptor LRP1 regulates age-dependent synaptic and neuronal degeneration by modulating brain lipid metabolism. - Journal of Neurosci, - 2010 -
4) LRP1 shedding in human brain: roles of ADAM10 and ADAM17. - Molecular Neurodegeneration - 2009 -
5) Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal A{lower case beta}42 uptake and lysosomal accumulation - PLoS One - 2010 -
6) Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase - ProcNatlAcadSci U S A - 2012 -
7) HeparanSulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-{ beta} Uptake. - Journal of Neurosci - 2012 -
8) Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis - Oncogene - 2010 -
9) Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4 - Journal of Cell Science - 2010 -
10) The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells - Journal of Biological Chemistry - 2008 -
11) .LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein - Journal of Cell Science - 2008 -
12) Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain - Molecular Neurodegeneration - 2009 -
13) Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway - Journal of Biological Chemistry - 2009 -
 
报考意向 Ambition
 
 
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