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崔华
单位:化学系
地址:安徽省合肥市中国科技大学化学系
邮编:230026
电话:86-551-63600730
个人主页: http://cl.ustc.edu.cn
实验室介绍: http://cl.ustc.edu.cn
 
个人简历 Personal resume
1990年获得中国科技大学理学博士,同年任中国科技大学应用化学系讲师,1995年中国科技大学化学系副教授,2000年底入选中国科学院“引进国外杰出人才”,任中国科学技术大学化学系教授、博士生导师、分析化学教研室主任。其间曾先后在荷兰Utrecht大学和美国杰克逊州立大学作为博士后和访问学者从事研究工作。2006年获得国家自然科学基金委“国家杰出青年基金”。2012年获得中国化学会分析化学基础研究梁树权奖(国内分析化学的最高奖项),2013年获得“中国科学院第四届十大杰出妇女”称号。2014年10月被任命为2015-2016年国际生物发光与化学发光理事会成员。
研究方向:纳米化学发光与电致化学发光及其在免疫分析和核酸分析中的应用研究。

目前主要致力于基于新型发光功能化纳米探针的化学发光/电致化学发光超灵敏免疫分析和核酸分析方法的研究及其在疾病诊断与治疗、食品安全检测、环境监测等领域中的应用。近年来,在化学发光和电致化学发光领域取得了一系列重要的研究成果。发现电致化学发光的多通道发射现象及其对电极电位、电极材料和电极表面状态等的依赖性,开辟了电位分辨的电致化学发光这一新的研究领域,推动了电致化学发光的深入研究;率先将纳米修饰电极用于电致化学发光的研究,发现鲁米诺等传统电致化学发光体系在纳米修饰电极上具有优异的电致化学发光特性;发现金属纳米粒子可作为能量接受体、微尺度反应平台、还原剂、催化剂等参与液相化学发光反应,将液相化学发光反应的研究对象从分子、离子体系扩展到金属纳米体系,开发了一系列新的化学发光体系,发展了一系列新的免疫分析技术;发明了一系列简单的“直接键合法”,率先合成了发光试剂直接功能化的金属纳米材料和碳纳米材料,并将其作为生物分子的分析探针和分析界面,发展了一系列高灵敏度的基于标记技术和无标记的化学发光分析新方法,并将其用于结核菌、心肌肌钙蛋白、肿瘤标志物等检测。这些研究开创了化学发光与电致化学发光新的研究领域,不仅对化学发光、电致化学发光和纳米科学的基础理论研究具有重要的意义,而且在分析化学、生命科学、环境科学领域具有广阔的应用前景。相关工作在Anal. Chem.、Chem. Eur. J、Chem. Commun. J. Phys. Chem. B/C、J. Mater. Chem.、Phys. Chem. Chem. Phys.等国际重要学术杂志上发表论文130余篇。申请中国专利5项、PCT4项、欧洲专利1项、美国专利1项,获得中国发明专利授权4项。受到同行专家的关注。与此同时,还承担了两门硕士研究生课和两门本科生专业课的教学工作,指导了三十多名博士、硕士研究生和本科生,目前已为国家培养博士、硕士二十多人。

 
研究方向 Research direction
1、化学发光/电致化学发光
2、纳米分析化学
3、免疫分析/DNA分析
 
招生信息 Enrollment information
考生应具有分析化学方面的专业知识,若具有生命科学方面的专业知识和纳米合成方面的研究经验更为理想。
 
论文专著 The monograph Researcher ID
1) A Homogeneous Signal-On Strategy for the Detection of rpoB Genes of Mycobacterium tuberculosis Based on Electrochemiluminescent Graphene Oxide and Ferrocene Quenching - Anal. Chem - 2014 - 2014, 86 (3), 1608–1613
2) Gold Nanoparticles Bifunctionalized by Chemiluminescence Reagent and Catalyst Metal Complexes: Synthesis and Unique Chemiluminescence Property - Anal. Chem. - 2014 - 2014, 86 (6), 2857–2861.
3) A General Chemiluminescence Strategy for Measuring Aptamer–Target Binding and Target Concentration - Anal. Chem - 2014 - 2014, 86 (11), 5559–5566.
4) Molecular Encoder - Decoder Based on Assembly of Graphene with Dye-labeled DNA - Chem. Commun. - 2014 - 2014,50, 7994-7997.
5) High-density assembly of chemiluminescence functionalized gold nanodots on multiwalled carbon nanotubes and their application as biosensing platforms - Nanoscale - 2014 - 2014, 6(5), 2563 - 2566.
6) A general strategy to prepare homogeneous and reagentless GO/lucigenin&enzyme biosensors for detection of small biomolecules - Biosens. Bioelectron. - 2014 - 2014, 57, 65-70.
7) A competitive immunoassay for sensitive detection of small moleculeschloramphenicol based on luminol functionalized silver nanoprobe - Anal. Chim. Acta - 2014 - 2014, 812, 236-242.
8) Electrochemiluminescence bioassay for thrombin based on dynamic assembly of aptamer, thrombin and N-(aminobutyl)-N-(ethylisoluminol) functionalized gold nanoparticles - Electrochimica Acta - 2014 - 2014, 125, 156–162.
9) A label-free electrochemiluminescence aptasensor for thrombin based on novel assembly strategy of oligonucleotide and luminol functionalized gold nanoparticles - Biosens. Bioelectron. - 2013 - 2013, 39, 261-267.
10) A novel homogeneous label-free aptasensor for 2,4,6-trinitrotoluene detection based on an assembly strategy of electrochemiluminescent graphene oxide with gold nanoparticles and aptamer - Biosens. Bioelectron. - 2013 - 2013, 43. 137–142.
11) Highly chemiluminescent gold nanopopcorns functionalized by N-(aminobutyl)-N-(ethylisoluminol) with lipoic acid as a co-stabilizing reagent - J. Mater. Chem. B - 2013 - 2013, 1, 970-977
12) Label free and homogeneous histone sensing based on chemiluminescence resonance energy transfer between lucigenin and gold nanoparticles - Biosens. Bioelectron. - 2013 - 2013, (47), 313-317
13) Preparation and electrochemiluminescent and photoluminescent properties of a graphene oxide colloid - Carbon - 2013 - 2013,(56),201-207
14) A homogeneous hemin/G-quadruplex DNAzyme based turn-on chemiluminescence aptasensor for interferon-gamma detection via in-situ assembly of luminol functionalized gold nanoparticles, deoxyribonucleic acid, interferon-gamma and hemin - Anal. Chim. Acta - 2013 - 2013, 60-64
15) N-(Aminobutyl)-N-(ethylisoluminol) and hemin dual-functionalized graphene hybrids with high chemiluminescence - Chem. Commun. - 2013 - 2013, 49, 9794-9796
16) Quenching the Chemiluminescence of Acridinium Ester by Graphene Oxide for Label-Free and Homogeneous DNA Detection - ACS Appl. Mater. Interfaces - 2013 - 2013, 5 (21), pp 11336–11340
17) Chemiluminescent Logic Gates Based on Functionalized Gold Nanoparticles/Graphene Oxide Nanocomposites - Chemistry - A European Journal - 2013 - 2013, 19(40), 13584–13589.
18) A graphene-based composite material noncovalently functionalized with a chemiluminescence reagent: synthesis and intrinsic chemiluminescence activity - Chem. Commun - 2012 - 2012, 48, 2894-2896.
19) Synthesis of highly chemiluminescent graphene oxide/silver nanoparticle nano-composites and their analytical applications - J. Mater. Chem - 2012 - 2012, 22, 9086-9091
20) Electrochemiluminescence biosensor for the assay of small molecule and protein based on bifunctional aptamer and chemiluminescent functionalized gold nanoparticles - Anal. Chim. Acta, - 2012 - 2012, 715, 86-92.
21) Synthesis of Dendritic Platinum Nanoparticles/Lucigenin/Reduced Graphene Oxide Hybrid with Chemiluminescence Activity - Chem. Eur. J., - 2012 - 2012, 18, 4823-4826.
22) Synthesis of electrochemiluminescent graphene oxide functionalized with a ruthenium(II) complex and its use in the detection of tripropylamine - Carbon, - 2012 - 2012, 50, 2539-2545.
23) Amino acids as the source for producing carbon nanodots: microwave assisted one-step synthesis, intrinsic photoluminescence property and intense chemiluminescence enhancement - Chem. Commun., - 2012 - 2012, 48, 9634-9636
24) Fabrication of Luminol and Lucigenin Bifunctionalized Gold Nnanoparticles/Graphene Oxide Nanocomposites with Dual-Wavelength Chemiluminescence - J. Phys. Chem. C, - 2012 - 2012, 116, 12953-12957.
25) Synthesis of N-(aminobutyl)-N-(ethylisoluminol) functionalized gold nanomaterials for chemiluminescent bio-probe - Chem. Commun. - 2011 - 47, 4959-4961.
26) Nanoparticle-based electrochemiluminescence immunosensor with enhanced sensitivity for cardiac troponin I using N-(aminobutyl)-N-(ethylisoluminol)-functionalized gold nanoparticles as labels - Biosens. Bioelectron - 2011 - 2011, 27, 18-24
27) Ultrasensitive electrochemiluminescence immunosensor based on luminol functionalized gold nanoparticle labeling - Biosens. Bioelectron. - 2010 - 25, 2290-2295.
28) pH-dependent catalytic properties of Pd-Ag nanoparticles in luminol chemiluminescence - Chem. Commun. - 2010 - 46, 1520-1522.
29) A novel electrochemiluminescence strategy for ultrasensitive DNA assay using luminol functionalized gold nanoparticles multi-labeling and amplification of gold nanoparticles and biotin-streptavidin system - Chem. Commun. - 2010 - 46, 7560-7562.
30) Time-tunable autocatalytic lucigenin chemiluminescence initiated by platinum nanoparticles and ethanol - Chem. Commun. - 2009 - 18, 2574-2576.
31) Growth mechanism of flowerlike gold nanostructures: Surface Plasmon Resonance (SPR) and Resonance Rayleigh Scattering (RRS) approaches to growth monitoring - J. Phys. Chem. C - 2008 - 112, 16348-16353.
32) Synthesis, characterization, and electrochemiluminescence of luminol-reduced gold nanoparticles and their application in a hydrogen peroxide sensor - Chem. Eur. J. - 2007 - 13, 6975-6984.
33) Light emission of gold nanoparticles induced by the reaction of bis(2,4,6-trichlorophenyl) oxalate and hydrogen peroxide - Anal. Chem. - 2005 - 77 (19), 6402-6406
34) Gold nanoparticle-catalyzed luminol chemiluminescence and its analytical applications - Anal. Chem. - 2005 - 77 (10), 3324-3329
35) Multi-channel electrochemiluminescence of luminol in neutral and alkaline aqueous solutions on a gold nanoparticles self-assembled electrode - Anal. Chem. - 2004 - 76, 4002-4010
 
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