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田志刚
单位:生命科学学院
地址:合肥黄山路443号
邮编:230027
电话:+86-551-63600845
个人主页: http://ioi.ustc.edu.cn/en/faculty/201007/t20100707_24302.html
实验室介绍:
 
个人简历 Personal resume
    田志刚,教授、博士生导师,中国科技大学医学中心主任、免疫学研究所所长,中国科学院天然免疫与慢性疾病重点实验室主任,中国免疫学会理事长(2014至今),国务院学位办学科评议组专家、国家基金委医学部咨询委员会委员。历任山东省医学科学院基础医学所所长(1996-2001),山东肿瘤生物治疗研究中心副主任、主任(1989-2001),中国免疫学会副理事长(2005-2014),中国科技大学生命科学学院副院长、院长(2005-2014)。1982年山西医科大学医学本科,1985年山东省医学科学院免疫学硕士,1989年白求恩医科大学免疫学博士毕业。1994-2001年之间作为访问学者多次短期赴美国NIH国立癌症研究所工作,曾任日本金泽大学国立癌研所访问教授(2001-2002)。2001年10月进入中国科技大学。2001年国家杰出青年科学基金获得者、2008和2011年国家基金委创新群体负责人、2008和2011年国家科技重大专项项目负责人、2012年国家重大研究计划项目首席科学家。
    2003年创办、承办并作为执行主编运行中国免疫学会英文会刊(Cell Mol Immunol);为《中国免疫学杂志》主编,《Cytokine》、《中国肿瘤生物治疗杂志》等刊物副主编。以通讯作者在Cell、Nat Immunol、Immunity、J Exp Med、J Clin Invest、Nat Commune、PNAS、Gastroenterology、Hepatology等发表SCI论文200余篇。2008年获国家自然科学二等奖(首位)、2011年获国家科技进步二等奖(第二位)。在美、德、日、加等参加国际会议或访问作学术报告30余次。获国家发明专利授权20余项。
 
研究方向 Research direction
1、NK细胞生物学
2、肝脏免疫学
3、天然免疫系统与重大疾病
 
招生信息 Enrollment information
仅招收硕博连读生, 必修免疫学或免疫生物学
 
论文专著 The monograph
1) NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice - Proceedings of National Academy of Science USA - 2007 - 104(18):7512-5.
2) TLR-3 ligand attenuates LPS-induced liver injury by down-regulation of TLR-4 expression on macrophages. - Proceedings of National Academy of Sciences USA - 2005 - 102 (47): 17077-17082.
3) NKG2D-retinoic acid early inducible-1 recognitionbetween natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.. - Hepatology - 2009 - 2009
4) Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. - Hepatology - 2008 - 47:648-58
5) Liver: An organ with predominant innate immunity.Review - Hepatology. - 2008 - 47(2):729-36.
6) Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice. - Hepatology - 2007 - 45(6):1400-12
7) Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. - Hepatology. - 2007 - 46(3):706-15
8) Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. - Hepatology - 2006 - 43(6):1211-9.
9) CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. - J Immunol. - 2008 - 181(10):7221- 9
10) Recognition of double-stranded RNA by Toll-like receptor 3 induces severe small intestinal injury in mice - Journal of Immunology - 2007 - 178(7):4548-56
11) NK3-like NK cells are involved in protective effect of poly I:C on type I diabetes in nonobese diabetic mice - Journal of Immunology - 2007 - 178 (4): 2141-2147
12) Toll-like receptor 9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. - J Immunol - 2009 - 2009
13) Human NK cells positively regulate gammadelta T cells in response to Mycobacterium tuberculosis - Journal of Immunology - 2006 - 176(4):2610-6.
14) Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. - Journal of Hepatology - 2006 - 44(3):446-54.
15) Liver-specific HBsAg transgenic mice are over-sensitive to Poly (I:C)-induced liver injury in NK cell- and IFN--dependent manners. - Journal of Hepatology - 2007 - 47(2):183-90.
16) Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. 23.Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. - Hepatology - 2011 - 53(1):219-29.
17) Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner - Hepatology - 2011 - 54(4):1179-89.
18) LFA-1 and CD2 synergize for the ERK1/2 activation in the NK cell immunological synapse. - J Biol Chem - 2009 - 2009
19) 15.Establishment, Characterization and Successful Adaptive Therapy against Human Tumors of NKG Cell, a New Human NK Cell Line - Cell Transplant. - 2011 - 2011 Jun 7.
20)  Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection - Journal of virology - 2012 - 卷: 86 期: 4 页: 2251-8
21) IFN-γ induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice - J Autoimmun - 2012 - 38(1):20-8.
 
报考意向 Ambition
 
 
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