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赖仞
单位:生命科学学院
地址:云南省昆明市教场东路32号
邮编:650223
电话:86-871-65197578
个人主页: http://sourcedb.kiz.cas.cn/zw/zjrc/yjy/200908/t20090813_2394253.html
实验室介绍:
 
个人简历 Personal resume
赖仞,研究员,博士生导师,中国科学院昆明动物研究所副所长,国家杰出青年基金获得者,万人计划领军人才,云南省科技领军人才,中国科学院天然活性多肽工程实验室主任,天然活性多肽国家联合地方工程中心主任,J Venom  Res副主编。主要从事天然药物来源的活性多肽与活性蛋白组学、功能、作用机制研究,基于天然活性多肽的分子改造和药物研发。 先后在Immunity、Chem Rev、Nat Immunol、 Cir Res、Nat Commun、FASEB J、Sci Adv、Plos Biology、Blood、Cell Res、PNAS等刊物发表论文220余篇,申请发明专利100 多项。曾获国家技术发明二等奖、全国创新争先奖状、云南省自然科学一等奖2项,已培养研究生60余人。
 
研究方向 Research direction
1、天然药物功能蛋白质与多肽组学研究
2、天然药物来源的活性多肽/蛋白结构、功能、作用机制基础和应用研究
3、新药研发
 
招生信息 Enrollment information
具备生物化学和分子生物学基础理论知识,对蛋白结构功能、人类疾病机理、新药研发等方向具有研究兴趣
 
论文专著 The monograph
1) Antimicrobial peptide LL-37 forms complex with bacterial DNA to fac... - Science Bulletin - 2018 - 63 (20)
2) A pain-inducing centipede toxin targets the heat activation machine... - Nat Commun - 2015 - 6
3) Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escap... - Immunity - 2015 - 43(1)
4) A bimodal activation mechanism underlies scorpion toxin-induced pain. - Science Advances - 2017 - 3(6)
5) Centipedes subdue giant prey by blocking KCNQ channels. - Proc Natl Acad Sci U S A - 2018 - 115(7)
6) Salivary factor LTRIN from Aedes aegypti facilitates the transmis ... - Nature Immunology - 2018 - 19(4)
7) Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models. - Cell Res - 2021 - 1
8)  A plant-derived TRPV3 inhibitor suppresses pain and itch. - Br J Pharmacol. - 2021 - in press.
9) Transferrin plays a central role in coagulation balance by interacting with clotting factors. - Cell Res. - 2020 - 30(2)
10) A paradigm of thermal adaptation in penguins and elephants by tuning cold activation in TRPM8. - Proc Natl Acad Sci U S A. - 2020 - 117(15)
11) Iron-Deficiency and Estrogen Are Associated with Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability. - Circ Res. - 2020 - 127(5)
12) Target switch of centipede toxins for antagonistic switch. - Sci Adv. - 2020 - 6(32)
13) 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation. - Blood. - 2020 - 136(8)
14) Why wild giant pandas frequently roll in horse manure. - Proc Natl Acad Sci U S A. - 2020 - in press
15) Molecular basis for heat desensitization of TRPV1 ion channels. - Nat Commun. - 2019 - 10(1)
16) Molecular game theory for a toxin-dominant food chain model. - National Science Review - 2019 - 6
17)  The antimicrobial peptide ZY4 combats multidrug-resistant P. aeruginosa and A. baumannii infection. PNAS, 2019,116(52) 26516–26522. - PNAS - 2019 - 116(52)
18) Molecular mechanism of the tree shrew\'s insensitivity to spicin... - PLoS Biol - 2018 - 16(7)
19) The chemistry and biological activities of peptides from amphibian skin secretions. - Chem Rev. - 2015 - 115(4)
20) Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. - Proc Natl Acad Sci U S A. - 2013 - 110(43)
 
报考意向 Ambition
 
 
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