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李壮
单位:中国科学院长春应用化学研究所电分析化学国家重点实验室
地址:吉林省长春市人民大街5625号
邮编:130022
电话:0431-85262057
个人主页: http://yjsb.ciac.jl.cn/daoshi_read.php?brow=60&lb=%B5%BC%CA%A6%BC%F2%BD%E9
实验室介绍:
 
个人简历 Personal resume
中国科学院长春应用化学研究所,电分析化学国家重点实验室,研究员,长期从事DNA 与蛋白质的SPM 研究、高灵敏痕量分析、纳米器件的加工等方面的研究。
教育经历:
1.1987–1990, 中国科学院长春应用化学研究所, 分析化学, 博士,
导师:董绍俊
2.1984–1987, 中国科学院长春应用化学研究所, 高分子化学, 硕士,
导师:刘国智,许肖龙
3.1979–1983, 延安大学, 化学, 学士, 导师:辅导员刘庆利
科研与学术工作经历:
1.1998-至今,中国科学院长春应用化学研究所,电分析化学,研究员
2.1995-1998,中国科学院长春应用化学研究所,电分析化学,副研究员
3.1993-1995,德国Jena分子生物技术研究所,客座科学家 
4.1991-1993,吉林大学光化学研究室,博士后
5.1983-1984,陕西省榆林地区教研室,化学,教学研究员
主持或参加科研项目
1. 国家自然科学基金面上项目,21275135,超疏水微纳米阵列的制备及高灵敏表面增强拉曼散射分析研究,2013/01-2016/12,80万元,在研,主持;
2. 国家自然科学基金面上项目,20775077,可控纳米线的制备及表面增强拉曼散射研究,2008/01-2010/12,28万元,已结题,主持;
3. 国家自然科学基金面上项目,30070417,扫描探针显微镜对基因组DNA高分辨物理图制作研究,2001/01-2003/12,24万元,已结题,主持;
4. 973计划项目,2010CB933603,03 课题-基于纳米材料与技术发展高效、快速、智能检测表征系统的新原理、新方法,2010/01-2014/08,496万,已结题,主持;
5. 中国科学院知识创新工程重要方向项目,KJCX2-YW-H11,脑中化学信息物质的时间分辨分析-03 课题:识别分析,2007/09-2010/12,已结题,主持;
 
研究方向 Research direction
1、DNA与蛋白质相互作用可视化研究/扫描探针显微学
2、 纳米器件及电化学
3、 环境污染物的检测与治理
 
招生信息 Enrollment information
专业背景:分析化学,材料化学,生物化学,物理学等。
考试科目:同中国科技大学招生考试。
科研条件:课题组拥有小型紫外可见光谱仪(CHEM4-UV-VIS, Ocean Optics, USA),紫外-可见光谱仪(T6 新世纪),荧光光纤光谱仪(Maya2000pro, Ocean Optics,USA),可见近红外光谱仪(CHEMUSB4-VIS-NIR, Ocean Optics, USA),激光共聚焦拉曼(激发线514 nm)、小型拉曼光谱仪(激发线785 nm)、多功能SPM(Multimode Ⅷ, Veeco, USA)、(Nanoscope Ⅲa,DI,USA)和扫描探针显微系统(Dimension ICON, Veeco, USA)及电化学工作站。此外,课题组隶属于电分析化学国家重点实验室,可以利用的资源包括:共聚焦荧光倒置显微镜、细胞培养室、流式细胞仪、PCR、FTIR、圆二色光谱仪、紫外-可见光谱仪、荧光光谱仪和常规实验设备。中科院长春应用化学研究所拥有高分辨透射电子显微镜、扫描电子显微镜、X 射线衍射仪、光电子能谱仪和质谱等实验仪器可供使用。
学生待遇:同中国科学院长春应用化学研究所研究生待遇。
 
论文专著 The monograph
1) Prussian blue nanocubes peroxidase mimetic-based colorimetric assay for screening acetylcholinesterase activity and its inhibitorOriginal - Sensors and Actuators B: Chemical - 2017 - 2017年
2) Label-free detection of acetylcholinesterase and its inhibitor based on the in situ formation of fluorescent copper nanoparticlesOriginal - Sensors and Actuators B: Chemical - 2017 - 2017年
3) Colorimetric determination of the activity of acetylcholinesterase and its inhibitors by exploiting the iodide-catalyzed oxidation of 3,3',5,5'-tetramethylbenzidine by hydrogen peroxide - Microchimica Acta - 2016 - 2016年第九期
4) Direct growth of pod-like Cu2O nanowire arrays on copper foam: Highly sensitive and efficient nonenzymatic glucose and H2O2 biosensor - Sensors and Actuators B: Chemical - 2016 - 2016年
5) Colorimetric assay for acetylcholinesterase and inhibitor screening based on the Ag [I] ion-3,3 ',5,5 '-tetramethylbenzidine (TMB) - Sensors and Actuators B: Chemical - 2016 - 2016年
6) Rapid Preparation of Crosslinked N-doped Graphene by Burning Method for High-Performance Electrochemical Capacitors - Electrochimica Acta - 2016 - 2016年
7) A facile enhancement in battery-type of capacitive performance of spinel NiCo2O4 nanostructure via directly tuning thermal decomposition temperature - Electrochimica Acta - 2016 - 2016年
8) CuO nanothorn arrays on three-dimensional copper foam as an ultra-highly sensitive and efficient nonenzymatic glucose sensor - RSC Advances - 2016 - 2016年第二十期
9) Colorimetric detection of sulfide ions in water samples based on the in situ formation of Ag2S nanoparticles - Sensors and Actuators B: Chemical - 2015 - 2015年
10) Carbon dots based fluorescent sensor for sensitive determination of hydroquinone - Talanta - 2015 - 2015年
11) Facile Synthesis of Nitrogen and Sulfur Dual-doped Hierarchical Micro/mesoporous Carbon Foams as Efficient Metal-free Electrocatalysts for Oxygen Reduction Reaction - Electrochimica Acta - 2015 - 2015年
12) Aptamer-based colorimetric biosensing of abrin using catalytic gold nanoparticles - Analys - 2015 - 2015年第十期
13) Label-free fluorescence detection of mercury ions based on the regulation of the Ag autocatalytic reaction - Analyst - 2015 - 2015年第十期
14) A facile label-free colorimetric aptasensor for ricin based on the peroxidase-like activity of gold nanoparticles - RSC Advances - 2015 - 2015年第二十一期
15) Highly sensitive and selective colorimetric detection of glutathione based on Ag [I] ion-3,3 ',5,5 '-tetramethylbenzidine (TMB) - Biosensors and Bioelectronics - 2015 - 2015年
16) Nitrogen and fluorine dual-doped mesoporous graphene: a high-performance metal-free ORR electrocatalyst with a super-low HO2- yield - Nanoscale - 2015 - 2015年第七期
17) Visual detection of melamine based on the peroxidase-like activity enhancement of bare gold nanoparticles - Biosensors and Bioelectronics - 2014 - 2014年
18) Label-free turn-on fluorescent detection of melamine based on the anti-quenching ability of Hg2+ to gold nanoclusters - Biosensors and Bioelectronics - 2014 - 2014年
19) A carbon dot based biosensor for melamine detection by fluorescence resonance energy transfer - Sensors and Actuators B: Chemical - 2014 - 2014年
20) DNA-templated synthesis of nickel cobaltite oxide nanoflake for high-performance electrochemical capacitors - Electrochimica Acta - 2014 - 2014年
21) Highly sensitive and rapid visual detection of ricin using unmodified gold nanoparticle probes - RSC Advances - 2014 - 2014第八十三期
22) Facile fabrication of CuO nanowire modified Cu electrode for non-enzymatic glucose detection with enhanced sensitivity - RSC Advances - 2014 - 2014年第五十五期
23) A new method to determine the thickness of platinum nanofilm simply by measuring its electrical resistance - Analytical Methods - 2014 - 2014年第二期
24) Facile preparation of silver nanoparticle films as an efficient surface-enhanced Raman scattering substrate - Applied Surface Science - 2013 - 2013年
25) Electrospun carbon nanofibers with manganese dioxide nanoparticles for nonenzymatic hydrogen peroxide sensing - Journal of Materials Science - 2013 - 2013年第十四期
26) Electrochemical Deposition of Nickel Nanoparticles on Reduced Graphene Oxide Film for Nonenzymatic Glucose Sensing - Electroanalysis - 2013 - 2013年第四期
27) Fluorescent sensing of cocaine based on a structure switching aptamer, gold nanoparticles and graphene oxide - Analyst - 2013 - 2013年第二十三期
28) Facile synthesis of Prussian blue @ gold nanocomposite for nonenzymatic detection of hydrogen peroxide - RSC Advances - 2013 - 2013年第二十六期
29) A graphene oxide based biosensor for microcystins detection by fluorescence resonance energy transfer - Biosensors and Bioelectronics - 2012 - 2012年第一期
30) Graphene-Pt nanocomposite for nonenzymatic detection of hydrogen peroxide with enhanced sensitivity - Electrochemistry Communications - 2011 - 2011年第十期
31) Silver Nanoparticles Coated Zinc Oxide Nanorods Array as Superhydrophobic Substrate for the Amplified SERS Effect - Journal of Physical Chemistry C - 2011 - 2011年第二十期
32) Assembly of Ni(OH)(2) nanoplates on reduced graphene oxide: a two dimensional nanocomposite for enzyme-free glucose sensing - Journal of Materials Chemistry - 2011 - 2011年第四十二期
33) Metallic nanostructures assembled by DNA and related applications in surface-enhancement Raman scattering (SERS) detection - Journal of Materials Chemistry - 2011 - 2011年第四十二期
34) Formation of Gold Nanoparticle Decorated Lysozyme Microtubes - Biomacromolecules - 2011 - 2011年第六期
35) Interaction between DNA and Microcystin-LR Studied by Spectra Analysis and Atomic Force Microscopy - Biomacromolecules - 2011 - 2011年第三期
36) Architecture of electrospun carbon nanofibers-hydroxyapatite composite and its application act as a platform in biosensing - Sensors and Actuators B: Chemical - 2011 - 2011年第一期
37) Au nanocages for highly sensitive and selective detection of H2O2 - Journal of Electroanalytical Chemistry - 2011 - 2011年
38) Carbon nanotube decorated with silver nanoparticles via noncovalent interaction for a novel nonenzymatic sensor towards hydrogen peroxide reduction - Journal of Electroanalytical Chemistry - 2011 - 2011年
39) DNA adsorption and desorption on mica surface studied by atomic force microscopy - Applied Surface Science - 2011 - 2011年第十五期
40) Carbon nanotube/raspberry hollow Pd nanosphere hybrids for methanol, ethanol, and formic acid electro-oxidation in alkaline media - Journal of Colloid and Interface Science - 2010 - 2010年第一期
41) Facile synthesis of urchin-like gold submicrostructures for nonenzymatic glucose sensing - Talanta - 2010 - 2010年第五期
42) Novel nonenzymatic hydrogen peroxide sensor based on iron oxide-silver hybrid submicrospheres - Talanta - 2010 - 2010年第四-五期
43) Facile fabrication of single crystal gold nanoplates with micrometer lateral size - Colloids and Surface A - 2010 - 2010年第二-三期
44) Seed-Mediated Synthesis of Au Nanocages and Their Electrocatalytic Activity towards Glucose Oxidation - Chemistry-A European Journal - 2010 - 2010年第三十期
45) Novel Hybrid Electrocatalyst with Enhanced Performance in Alkaline Media: Hollow Au/Pd Core/Shell Nanostructures with a Raspberry Surface - Journal of Physical Chemistry C - 2009 - 2009年第三十八期
46) Type I collagen-mediated synthesis of noble metallic nanoparticles networks and the applications in Surface-Enhanced Raman Scattering and electrochemistry - Talanta - 2009 - 2009年第三期
47) Influence of Polyelectrolyte on DNA-RecA Nucleoprotein Filaments: Poly-L-Lysine Used as a Model - ChemPhysChem - 2009 - 2009年第九-十期
48) Electrodeposition of platinum nanoclusters on type I collagen modified electrode and its electrocatalytic activity for methanol oxidation - Applied Surface Science - 2009 - 2009年第十五期
49) Surface-Relevant Regulable DNA Toroids Induced by Dopamine - Journal of Physical Chemistry B - 2009 - 2009年第十七期
50) Atomic force microscopy and surface-enhanced Raman scattering detection of DNA based on DNA-nanoparticle complexes - Nanotechnology - 2009 - 2009年第十二期
51) Controllable synthesis of gold nanowires - Materials Letters - 2008 - 2008年第二十五期
52) DNA-Templated Gold Nanoparticles Formation - Journal of Nanoscience and Nanotechnology - 2008 - 2008年第九期
53) Synthesis and assembly of Au-Pt bimetallic nanoparticles - Materials Letters - 2008 - 2008年第八-九期
54) Type I collagen-templated assembly of silver nanoparticles and their application in surface-enhanced Raman scattering - Nanotechnology - 2008 - 2008年第十一期
55) Aggregation-based growth of silver nanowires at room temperature - Applied Surface Science - 2008 - 2008年第九期
56) Fabrication, characterization, and application in surface-enhanced Raman spectrum of assembled type-I collagen-silver nanoparticle multilayered films - Journal of Chemical Physics - 2008 - 2008年第七期
57) Atomic force microscopic study of low temperature induced disassembly of RecA-dsDNA filaments - Journal of Physical Chemistry B - 2008 - 2008年第三期
58) Photochemical synthesis and self-assembly of gold nanoparticles - Colloids and Surface A - 2008 - 2008年第二-三期
59) Self-assembly of lambda-DNA networks/Ag nanoparticles: Hybrid architecture and active-SERS substrate - Journal of Colloid and Interface Science - 2008 - 2008年第一期
60) Ethanol-induced formation of silver nanoparticle aggregates for highly active SERS substrates and application in DNA detection - Journal of Physical Chemistry C - 2008 - 2008年第五期
61) Synthesis, characterization, and self-assembly of protein lysozyme monolayer-stabilized gold nanoparticles - Langmuir - 2007 - 2007年第二十一期
62) Type I collagen-mediated synthesis and assembly of UV-photoreduced gold nanoparticles and their application in surface-enhanced Raman scattering - Journal of Physical Chemistry C - 2007 - 2007年第五期
63) Room temperature ionic liquid doped DNA network immobilized horseradish peroxidase biosensor for amperometric determination of hydrogen peroxide - Analytical and Bioanalytical Chemistry - 2007 - 2007年第二期
64) Large-scale, uniform DNA network on 11-mercaptoundecanoic acid modified gold (111) surface: Atomic force microscopy study - Microscopy Research and Technique - 2007 - 2007年第七期
65) Controlled organization of silver nanoparticles into network assemblies by tuning pH values - Chemistry Letters - 2007 - 2007年第五期
66) Electrostatic assembly of protein lysozyme on DNA visualized by atomic force microscopy - Applied Surface Science - 2007 - 2007年第九期
67) In-situ fabrication of hybrid polyoxometalate nanoparticles composite films - Thin Solid Films - 2007 - 2007年第七-八期
68) Effects of bridge ions, DNA species, and developing temperature on flat-lying DNA monolayers - Journal of Physical Chemistry B - 2007 - 2007年第二期
69) Self-assembled gold nanoparticle chains in presence of silver ions - Chemistry Letters - 2007 - 2007年第一期
70) Manipulation, dissection, and lithography using modified tapping mode atomic force microscope - Microscopy Research and Technique - 2006 - 2006年第十二期
71) A novel strategy to construct a flat-lying DNA monolayer on a mica surface - Journal of Physical Chemistry B - 2006 - 2006年第二十二期
72) Electrostatic-assembly metallized nanoparticles network by DNA template - Talanta - 2006 - 2006年第六十八期
73) Fabrication of silver nanoparticles ring templated by plasmid DNA - Applied Surface Science - 2006 - 2006年第二百五十二期
74) Self-assembly of cinnamic acid-capped gold nanoparticles - Nanotechnology - 2006 - 2006年第十七期
75) Electrostatic assembly of Cu2O nanoparticles on DNA templates - Applied Surface Science - 2006 - 2006年第二百五十二期
76) Solution-phase synthesis of Au@ZnO core-shell composites - Materials Letters - 2006 - 2006年第六十期
77) A novel hydrogen peroxide sensor based on horseradish peroxidase immobilized in DNA films on a gold electrode - Sensors and Actuators B: Chemical - 2006 - 2006年第一百一十四期
78) Direct construction of poly-L-lysine nanostructure by Dip-pen nanolithography - Chemical Research in Chinese Universities - 2005 - 2005年第二十六期
79) Electrostatic assembly of CTAB-capped silver nanoparticles along predefined gimel-DNA template - Applied Surface Science - 2005 - 2005年第二百五十二期
80) Synthesis of nanowires, nanorods and nanoparticles of ZnO through modulating the ratio of water to methanol by using a mild and simple solution method - Materials Chemistry and Physics - 2005 - 2005年第八十九期
81) DNA-network-templated self-assembly of silver nanoparticles and their application in surface-enhanced Raman scattering - Journal of Physical Chemistry B - 2005 - 2005年第一百零九期
82) Nanoscale structures of circle-MgCl2 constructed by plasmid DNA templates - Superlattices and Microstructures - 2005 - 2005年第三十七期
83) One-step synthesis of silver nanoparticles, nanorods, and nanowires on the surface of DNA network - Journal of Physical Chemistry B - 2005 - 2005年第一百零九期
84) A simple method for the preparation of ultrahigh sensitivity surface enhanced Raman scattering (SERS) active substrate - Applied Surface Science - 2005 - 2005年第二百四十二期
85) Immobilization of DNA on 11-mercaptoundecanoic acid-modified gold(111) surface for atomic force microscopy imaging - Microscopy Research and Technique - 2005 - 2005年第六十八期
86) Mechanically engraved mica surface using the atomic force microscope tip facilitates return to a specific sample location - Microscopy Research and Technique - 2005 - 2005年第六十六期
87) Imaging DNA molecules on mica surface by atomic force microscopy in air and in liquid - Microscopy Research and Technique - 2005 - 2005年第六十六期
88) Observation of the mica surface by atomic force microscopy - Micron - 2005 - 2005年第三十六期
89) Immobilization and condensation of DNA with 3-aminopropyltriethoxysilane studied by atomic force microscopy - Journal of Microscopy - 2005 - 2005年第二百一十八期
90) Atomic force microscope investigation of large-circle DNA molecules - Analytical Biochemistry - 2004 - 2004年第三百二十五期
91) The influence of tip performance on scanning probe lithography - Applied Surface Science - 2004 - 2004年第二百二十一期
92) Direct patterning of rhodamine 6G molecules on mica by dip-pen nanolithography - Applied Surface Science - 2004 - 2004年第二百三十六期
93) Biological samples investigated by atomic force microscopy - Chinese Journal of Analytical Chemistry - 2004 - 2004年第三十二期
94) DNA network structures on various solid substrates investigated by atomic force microscopy - Analytical Sciences - 2004 - 2004年第二十期
95) AFM studies of DNA structures on mica in the presence of alkaline earth metal ions - Biophysical Chemistry - 2003 - 2003年第一百零四期
96) The structural transition of DNA-Tris(1,10-phenanthroline) cobalt(III) complexes in ethanol-water solution - Biochemical and Biophysical Research Communication - 2002 - 2002年第二百二十九期
97) The AFM characterization of Ni(phen)(3)(2+) fixing effects on DNA - Chemical Journal of Chinese Universities - 2002 - 2002年第二十三期
98) Construction and control of plasmid DNA network - Analyst - 2002 - 2002年第一百二十七期
99)  relocated technique of atomic force microscopy (AFM) samples and its application in molecular biology - Ultramicroscopy - 2002 - 2002年第九十二期
100) Deoxyribonucleic acid sample preparation in scanning probe microscope - Chinese Journal of Analytical Chemistry - 2001 - 2001年第二十九期
101) Plasmid DNA network on a mica substrate investigated by atomic force microscopy. - Analytical Sciences - 2001 - 2001年第十七期
102) Self-assembled monolayer of ssDNA on Au(111) substrate - Surface Science - 2001 - 2001年第四百八十期
103) Imaging chromosome by a lateral force microscope - Analytical Sciences - 2000 - 2000年第十六期
104) 原子力显微镜成像及力谱在生物研究中的应用 - 延安大学学报(自然科学版) - 2012 - 2012年第三十一期
105) 零污染、零感染、零废弃物排放,变废为宝 - 科学中国人 - 2012 - 2012年第五期
 
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