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于聪
单位:中国科学院长春应用化学研究所,电分析化学国家重点实验室
地址:吉林省,长春市,人民大街5625号
邮编:130022
电话:0431-85262710
个人主页: https://www.x-mol.com/groups/yu_cong
实验室介绍: https://bioanalysissensing.wixsite.com/congyu
 
个人简历 Personal resume
于聪(博士,研究员,博士生导师),1991年毕业于吉林大学化学系,1993年赴瑞典隆德大学生物化学系攻读博士学位,师从非共价分子印记技术创始人Prof. Klaus Mosbach,并于1998年获得博士学位。1999年至2002年在美国加州大学,伯克利分校化学系做博士后工作,师从Prof. J.M.J. Fréchet (美国国家科学院、工程学院双院士)。2002至2008年在香港大学,中国科学院院士任咏华教授研究组任高级研究助理,在此期间主要从事核酸相关的传感、检测的研究。2008年应聘到中国科学院长春应用化学研究所工作。多年来带领课题组成员致力于结合荧光小分子探针、纳米探针、功能核酸等方面相关知识,开发检测分析核酸、蛋白质,活细胞成像,肿瘤治疗等的研究新方法。在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun., Org. Lett., Chem. Eur. J.等国际核心期刊发表高质量论文多篇。主持了国家科技部“973计划”重大研究计划项目子课题以及多项国家自然科学基金项目、省市科研项目等。
 
研究方向 Research direction
1、生物分析,化学生物学
2、荧光探针,纳米探针
3、活细胞成像,肿瘤治疗
 
招生信息 Enrollment information
生源背景:分析化学,化学生物学,有机合成,分子生物学,材料化学,物理化学,细胞生物学,医学等相关专业
 
论文专著 The monograph
1) Wang, Bin(#),Yu, Cong(*),Fluorescence Turn-On Detection of a Protein through the Reduced Aggregation of a Perylene Probe - Angewandte Chemie International Edition - 2010 - 49(8):1485-1488
2) Wang, Yan(#),Chen, Jian,Chen, Yang,Li, Wenying,Yu, Cong(*),Polymer-Induced Perylene Probe Excimer Formation and Selective Sensing of DNA Methyltransferase Activity through the Monomer-Excimer Transition - Analytical Chemistry - 2014 - 86(9):4371-4378
3) Jian Chen(#), Hong Jiang, Huipeng Zhou, Zhenzhen Hu, Niu Niu, Sohail Anjum Shahzad and Cong Yu(*), Specific detection of cancer cells through aggregation-induced emission of a light-up bioprobe - Chemical Communications - 2017 - 53,2398-2401
4) Cuiyun Zhang(#), You Fan, Yunyi Zhang, Cong Yu(*), Hongfei Li, Yu Chen, Ian W. Hamley, and Shichun Jiang (*), Self-Assembly Kinetics of Amphiphilic Dendritic Copolymers - Macromolecules - 2017 - 50,1657-1665
5) Yunyi Zhang(#), Cuiyun Zhang, Jian Chen, Yongxin Li, Huipeng Zhou, Cong Yu (*) and Shichun Jiang(*) A real-time fluorescence turn-on assay for acetylcholinesterase activity based on the controlled release of a perylene probe from MnO2 nanosheets - Journal of Materials Chemistry C - 2017 - 5,4691-4694
6) Xinan Huang (#), Hong Jiang, Yongxin Li, Cong Yu (*), Synthesis of silica nanoparticles doped with [Ru(bpy)3]2+ and decorated with silver nanoclusters for the ratiometric photoluminescent determination and intracellular imaging of Cu(II) ions - Microchim Acta - 2017 - 184:2325-2331
7) Yongxin Li(#), Huipeng Zhou, Jian Chen, Sohail Anjum Shahzad, Cong Yu(*), Controlled self-assembly of small molecule probes and the related applications in bioanalysis - Biosensors and Bioelectronics - 2016 - 76,38-53
8) Meiding Yang(#), Jian Chen, Huipeng Zhou, Wenying Li, Yan Wang, Juanmin Li, Cuiyun Zhang, Chuibei Zhou, Cong Yu(*), Polycation-induced benzoperylene probe excimer formation and the ratiometric detection of heparin and heparinase - Biosensors and Bioelectronics - 2016 - 75,404-410
9) Bin Wang(*), YanfenChen, YuanyaWu, BoWeng, YingshuaiLiu, Zhisong Lu, ChangMingLi, CongYu(*), Aptamer induced assembly of fluorescent nitrogen-doped carbon dots on gold nanoparticles for sensitive detection of AFB1 - Biosensors and Bioelectronics - 2016 - 78,23-30
10) Cuiyun Zhang,(#) Cong Yu (*), Yuyuan Lu, Hongfei Li, Yu Chen, Hong Huo, Ian William Hamley and Shichun Jiang (*), Hydrodynamic behaviors of amphiphilic dendritic polymers with different degrees of amidation - Polymer Chemistry - 2016 - 7,3126-3133
11) Juanmin Li(#),Yongxin Li, Sohail Anjum Shahzad, Jian Chen, Yang Chen, Yan Wang, Meiding Yang, Cong Yu(*), Fluorescence turn-on detection of glucose via the Ag nanoparticle mediated release of a perylene probe - Chemical Communications - 2015 - 51, 6354-6356
12) Wenying Li(#),Qingfeng Zhang, Huipeng Zhou, Jian Chen, Yongxin Li, Cuiyun Zhang, Cong Yu(*), Chemiluminescence Detection of a Protein through the Aptamer-Controlled Catalysis of a Porphyrin Probe - Analytical Chemistry - 2015 - 87, 8336-8341
13) Chen, Jian(#),Wang, Yan,Li, Wenying,Zhou, Huipeng,Li, Yongxin,Yu, Cong(*),Nucleic Acid-Induced Tetraphenylethene Probe Noncovalent Self-Assembly and the Superquenching of Aggregation-Induced Emission - Analytical Chemistry - 2014 - 86(19):9866-9872
14) Li, Wenying(#),Yang, Yue,Chen, Jian,Zhang, Qingfeng,Wang, Yan,Wang, Fangyuan,Yu, Cong(*),Detection of lead(II) ions with a DNAzyme and isothermal strand displacement signal amplification - Biosensors and Bioelectronics - 2014 - 53:245-249
15) Huping Jiao (#), Jian Chen, Wenying Li, Fangyuan Wang, and Cong Yu(*), Nucleic Acid-Regulated Perylene Probe-Induced Gold Nanoparticle Aggregation: A New Strategy for Colorimetric Sensing of Alkaline Phosphatase Activity and Inhibitor Screening - ACS Applied Materials & Interfaces - 2014 - 6(3),1979-1985
16) Chen, Yang,Li, Wenying,Wang, Yan,Yang, Xudong,Chen, Jian,Jiang, Yingnan,Yu, Cong(*),Cysteine-directed fluorescent gold nanoclusters for the sensing of pyrophosphate and alkaline phosphatase - Journal of Materials Chemistry C - 2014 - 2(20):4080-4085
17) Wang, Yan(#),Chen, Jian,Jiao, Huping,Chen, Yang,Li, Wenying,Zhang, Qingfeng,Yu, Cong(*),Polymer-Templated Perylene-Probe Noncovalent Self-Assembly: A New Strategy for Label-Free Ultrasensitive Fluorescence Turn-On Biosensing - Chemistry - A European Journal - 2013 - 19(38):12846-12852
18) Chen, Jian(#),Liao, Dongli,Wang, Yan,Zhou, Huipeng,Li, Wenying,Yu, Cong(*),Real-Time Fluorometric Assay for Acetylcholinesterase Activity and Inhibitor Screening through the Pyrene Probe Monomer-Excimer Transition - Organic Letters - 2013 - 15(9):2132-2135
19) Chen, Jian,Jiao, Huping,Li, Wenying,Liao, Dongli,Zhou, Huipeng,Yu, Cong(*),Real-time fluorescence turn-on detection of alkaline phosphatase activity with a novel perylene probe - Chemistry-An Asian Journal - 2013 - 8(1):276-281
20) Liao, Dongli,Chen, Jian,Zhou, Huipeng,Wang, Yan,Li, Yongxin,Yu, Cong(*),In Situ Formation of Metal Coordination Polymer: A Strategy for Fluorescence Turn-On Assay of Acetylcholinesterase Activity and Inhibitor Screening - Analytical Chemistry - 2013 - 85:2667-2672
21) Zhang, Qingfeng(#),Li, Wenying,Chen, Jian,Wang, Fangyuan,Wang, Yan,Chen, Yang,Yu, Cong(*),An Ultrasensitive Chemiluminescence Turn-on Assay for Protease and Inhibitor Screening with a Natural Substrate - Chemical Communications - 2013 - 49:3137-3139
22) Liao, Dongli(#),Chen, Jian,Li, Wenying,Zhang, Qingfeng,Wang, Fangyuan,Li, Yongxin,Yu, Cong(*),Fluorescence turn-on detection of a protein using cytochrome c as a quencher - Chemical Communications - 2013 - 49(82):9458-9460
23) Chen, Yang(#),Zhou, Huipeng,Wang, Yan,Li, Wenying,Chen, Jian,Lin, Quan(*),Yu, Cong(*),Substrate hydrolysis triggered formation of fluorescent gold nanoclusters - a new platform for the sensing of enzyme activity - Chemical Communications - 2013 - 49(84):9821-9823
24) Li, Wenying(#),Chen, Jian,Jiao, Huping,Zhang, Qingfeng,Zhou, Huipeng,Yu, Cong(*),A label-free real time fluorometric assay for protease and inhibitor screening with a released heme - Chemical Communications - 2012 - 48(81):10123-10125
25) Jiao, Huping(#),Wang, Bin,Chen, Jian,Liao, Dongli,Yu, Cong(*),Label free fluorescence turn-on detection of polynucleotide kinase activity with a perylene probe - Chemical Communications - 2012 - 48(63):7862-7864
26) Tang, Dan(#),Liao, Dongli,Zhu, Qiankun,Wang, Fangyuan,Jiao, Huping,Zhang, Yujing,Yu, Cong(*),Fluorescence turn-on detection of a protein through the displaced single-stranded DNA binding protein binding to a molecular beacon - Chemical Communications - 2011 - 47(19):5485-5487
27) Wang, Bin(#),Zhu, Qiankun,Liao, Dongli,Yu, Cong(*),Perylene probe induced gold nanoparticle aggregation - Journal of Materials Chemistry - 2011 - 21(13):4821-4826
28) Wang, Bin(#),Jiao, Huping,Li, Wenying,Liao, Dongli,Wang, Fangyuan,Yu, Cong(*),Superquencher formation via nucleic acid induced noncovalent perylene probe self-assembly - Chemical Communications - 2011 - 47(37):10269-10271
 
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