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刘志强
单位:中国科学院长春应用化学研究所国家电化学和光谱研究分析中心/科技部国家(长春)质谱中心
地址:吉林省长春市人民大街5625号
邮编:130022
电话:86-431-85262236/85262242
个人主页: http://yjsb.ciac.jl.cn/daoshi_read.php?brow=108&lb=%B5%BC%CA%A6%BC%F2%BD%E9
实验室介绍:
 
个人简历 Personal resume
    1962年生,1984年在吉林大学化学系获化学学士学位,1996年在吉林大学获理学博士学位,1997-1999年在中科院长春应化所从事博士后研究,2003/10-2004/01在澳大利亚Monash大学生物化学与分子生物学系作高级访问学者,2000年起在中科院长春应化所工作,现为国家电化学与光谱研究分析中心和国家科技部长春质谱中心主任。
已在Anal. Chem.、J. Chromatogr. A、Talanta、Anal Chim. Acta等SCI期刊上发表第一作者和通讯作者论文100篇。作为项目负责人先后承担国家科技支撑计划子课题(2项),国家科技部重大新药创制专项(3项),国家自然科学基金重点项目(1项),国家科技部九五重点科技攻关计划课题(1项),国家科技部、国家中医药管理局“九五”攀登计划预选项目(1项),国家科技部重大基础研究前期研究专项(1项),国家重点基础研究发展计划(973计划)子课题(2项),国家科技部创新方法工作专项(3项),国家自然科学基金面上项目(5项),中国科学院知识创新工程重要方向项目(2项),吉林省重大科技发展计划项目等三十余项科研课题。2001年获吉林省杰出青年基金,2004年获吉林省杰出人才基金,2004年获吉林省长春市政府特殊津贴,2005年获吉林省人民政府高级专家称号,2015年获吉林省“第五批拔尖创新人才第三层次人选”荣誉称号,获吉林省科技进步奖一等奖6项,二等奖2项,三等奖3项。
 
研究方向 Research direction
1、药物质谱及生物质谱
2、中药活性筛选、药效物质基础及作用机制研究
3、代谢组学及质谱新技术研究
 
招生信息 Enrollment information
欢迎具有化学(分析、生物、有机、物化化学等)、药学、药剂或药理学等背景的同学加入研究团队。 
 
论文专著 The monograph
1) Noncovalent Interactions between Superoxide Dismutase and Flavonoids Studied by Native Mass Spectrometry Combined with Molecular Simulations. - Analytical chemistry - 2016 - 88(23)
2) Identification of Unfolding and Dissociation Pathways of Superoxide Dismutase in the Gas Phase by Ion-Mobility Separation and Tandem Mass Spectrometry - Analytical Chemistry - 2014 - 86(23)
3)  Stepwise targeted matching strategy from in vitro to in vivo based on ultra-high performance liquid chromatography tandem mass spectrometry technology to quickly identify and screen pharmacodynamic constituents - Talanta - 2019 - 194
4) Benzophenone used as the photochemical reagent for pinpointing C=C locations in unsaturated lipids through shotgun and liquid chromatography-mass spectrometry approaches - Analytica Chimica Acta - 2018 - 1028
5) Putative multiple reaction monitoring strategy for the comparative pharmacokinetics of postoral administration Renshen-Yuanzhi compatibility through liquid chromatography-tandem mass spectrometry - Journal of Ginseng Research - 2020 - 44(1)
6)  Studies on the chemical and intestinal metabolic profiles of Polygalae Radix by using UHPLC-IT-MSn and UHPLC-Q-TOF-MS method coupled with intestinal bacteria incubation model in vitro - Journal of Pharmaceutical and Biomedical Analysis - 2018 - 148
7) Targeted Screening Approach to Systematically Identify the Absorbed Effect Substances of Poriacocos in Vivo Using Ultrahigh Performance Liquid Chromatography Tandem Mass Spectrometry - Journal of Agricultural and Food Chemistry - 2018 - 66
8) Study on the compatibility interactions of formula Ding-Zhi-Xiao-Wan based on their main components transport characteristics across Caco-2 monolayers model - Journal of Pharmaceutical and Biomedical Analysis - 2018 - 159
9)  Comprehensive characterization of in vivo metabolic profile of Polygalae radix based on ultra-high-performance liquid chromatography-tandem mass spectrometry - Journal of Pharmaceutical and Biomedical Analysis - 2018 - 165
10)  Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines - Journal of chromatography B - 2016 - 1026(SI)
11) Application of online microdialysis coupled with liquid chromatography–tandem mass spectrometry method in assessing neuroprotective effect of Coptidis Rhizoma on diabetic rats - Analytical Methods - 2015 - 7(1)
12) A study on the effective substance of the Wu-tou formula based on the metabonomic method using UPLC-Q-TOF-HDMS - Molecular BioSystems - 2015 - 11
13) Investigation of noncovalent interactions of aconitine with duplex, triplex and G-quadruplex DNA by electrospray ionization mass spectrometry - Rapid Communications in Mass Spectrometry - 2014 - 28(7)
14) Chemical profiling of Wu-tou decoction by UPLC-Q-TOF-MS - Talanta - 2014 - 118
15) A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. - Molecular BioSystems - 2014 - 10
16) Metabonomic Study of Wu-tou decoction in adjuvant-induced arthritis rat using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry - Journal of Chromatography B - 2014 - 953-954
17) Determination of pesticide residues in ginseng by dispersive liquid-liquid microextraction and ultra high performance liquid chromatography-tandem mass spectrometry - Journal of Chromatography B - 2013 - 917
 
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