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贺超良
单位:中国科学院长春应用化学研究所
地址:吉林省长春市人民大街5625号,生态室
邮编:130022
电话:86-431-85262901
个人主页: http://biopolymer.ciac.jl.cn/group-mlist.html/?group=9
实验室介绍:
 
个人简历 Personal resume
    贺超良,博士,中国科学院长春应用化学研究所研究员、博士生导师。2001年6月于华东理工大学应用化学专业获得工学学士学位,2007年1月于中国科学院长春应用化学研究所高分子化学与物理专业获得理学博士学位,师从陈学思院士。2007年3月至2010年8月,分别在韩国成均馆大学和加拿大渥太华大学从事博士后研究。2010年9月起于中国科学院长春应用化学研究所生态环境高分子材料重点实验室工作,历任副研究员、研究员。主要研究方向:(1)仿生智能性高分子水凝胶的设计、制备与生物医学应用;(2)抗肿瘤药物局部缓释水凝胶载体材料;(3)生物活性水凝胶组织修复与再生材料。
    已发表SCI论文100余篇;其中,以第一/通讯作者在Advanced Materials, National Science Review, ACS Nano, Biomaterials, Advanced Healthcare Materials, Journal of Controlled Release, Biomacromolecules等IF>5的SCI杂志发表论文50余篇,其中IF>10的论文20余篇。全部论文他引总计7000余次,单篇最高他引600余次,h-index为50。以第一发明人获得授权中国发明专利23项。2013年入选中国科学院青年创新促进会(2017年入选优秀会员)。2016年获得国家自然科学基金“优秀青年科学基金”。作为项目负责人主持或完成国家自然科学基金面上项目4项、青年基金1项,以及吉林省科技发展计划重点项目等。担任《Science China Technological Sciences》(IF: 3.903)、《Pharmaceutics》(IF: 6.525)、《SmartMat》、《中国科学:技术科学》等学术期刊青年编委或编委。
 
研究方向 Research direction
1、生物医用高分子材料
2、药物缓释水凝胶载体
3、组织修复与再生水凝胶
 
招生信息 Enrollment information
欢迎化学、高分子科学、材料科学、生物学等背景的硕士生和博士生
 
论文专著 The monograph
1) Mucoadhesive, Antibacterial, and Reductive Nanogels as a Mucolytic Agent for Efficient Nebulized Therapy to Combat Allergic Asthma - ACS Nano - 2022 - 16(7), 11161–11173
2) Biomedical polymers: synthesis, properties, and applications - Science China Chemistry - 2022 - 65(6), 1010-1075
3) Enhanced antitumor chemo-immunotherapy by local co-delivery of chemotherapeutics, immune checkpoint blocking antibody and IDO inhibitor using an injectable polypeptide hydrogel - Journal of Polymer Science - 2022 - 60(10), 1595-1609
4) Effect of polymer topology and residue chirality on biodegradability of polypeptide hydrogels - ACS Biomaterials Science & Engineering - 2022 - 8, 626-637
5) A pH-triggered self-unpacking capsule containing zwitterionic hydrogel-coated MOF nanoparticles for efficient oral exendin-4 delivery - Advanced Materials - 2021 - 33, 2102044
6) A fast and versatile cross-linking strategy via o-phthalaldehyde condensation for mechanically strengthened and functional hydrogels - National Science Review - 2021 - 8(4), nwaa128
7) Localized chemotherapy based on injectable hydrogel boosts the antitumor activity of adoptively transferred T lymphocytes in vivo - Advanced Healthcare Materials - 2021 - DOI: 10.1002/adhm.202100814
8) Rapidly Thermoreversible and Biodegradable Polypeptide Hydrogels with Sol–Gel–Sol Transition Dependent on Subtle Manipulation of Side Groups - Biomacromolecules - 2021 - 22, 3522-3533
9) Crucial impact of residue chirality on the gelation process and biodegradability of thermoresponsive polypeptide hydrogels - Biomacromolecules - 2021 - 22, 3992-4003
10) Physiologically relevant pH- and temperature-responsive polypeptide hydrogels with adhesive properties - Polymer Chemistry - 2021 - 12(19), 2832-2839
11) Injectable hydrogels as local depots at tumor sites for antitumor immunotherapy and immune-based combination therapy - Macromolecular Bioscience - 2021 - 21, 2100039
12) Design of an injectable polypeptide hydrogel depot containing the immune checkpoint blocker anti-PD-L1 and doxorubicin to enhance antitumor combination therapy - Macromolecular Bioscience - 2021 - 21, 2100049
13) Matrix metalloproteinase-sensitive poly(ethylene glycol)/peptide hydrogels as an interactive platform conducive to cell proliferation during 3D cell culture - Science China Technological Sciences - 2021 - 64(6), 1285-1294
14) Influence of residual chirality on the conformation and enzymatic degradation of glycopolypeptide based biomaterials - Science China Technological Sciences - 2021 - 64(3), 641-650
15) A nanocomposite vehicle based on metal-organic framework nanoparticle incorporated biodegradable microspheres for enhanced oral insulin delivery - ACS Applied Materials & Interfaces - 2020 - 12(20), 22581-22592
16) Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells - Science China Chemistry - 2020 - 63(8), 1100-1111
17) Thermosensitive polypeptide hydrogels co-loaded with two anti-tumor agents to reduce multi-drug resistance and enhance local tumor treatment - Advanced Therapeutics - 2020 - 3, 1900165
18) Injectable click polypeptide hydrogels via tetrazine-norbornene chemistry for localized cisplatin release - Polymers - 2020 - 12(4), 884
19) Enhanced local cancer therapy using a CA4P and CDDP co-loaded polypeptide gel depot - Biomaterials Science - 2019 - 7, 860-866
20) Injectable bioresponsive gel depot for enhanced immune checkpoint blockade - Advanced Materials - 2018 - 30, 1801527
21) pH- and amylase-responsive carboxymethyl starch/poly(2-isobutyl-acrylic acid) hybrid microgels as effective enteric carriers for oral insulin delivery - Biomacromolecules - 2018 - 19, 2123-2136
22) DOX/IL-2/IFN-γ co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment - Bioactive Materials - 2018 - 3, 118-128
23) Hydrogels based on pH-responsive reversible carbon–nitrogen double-bond linkages for biomedical applications. - Materials Chemistry Frontiers - 2018 - 2, 1765-1778
24) Injectable enzymatically cross-linked hydrogels with light-controlled degradation profile - Macromolecular Rapid Communications - 2018 - 39(18), 1800272
25) Dual stimuli-responsive nanoparticle-incorporated hydrogels as an oral insulin carrier for intestine-targeted delivery and enhanced paracellular permeation - ACS Biomaterials Science & Engineering - 2018 - 4(8), 2889-2902
26) Injectable hydrogels as unique platforms for local chemotherapeutics‐based combination antitumor therapy - Macromolecular Bioscience - 2018 - 18, 1800240
27) Interleukin-15 and cisplatin co-encapsulated thermosensitive polypeptide hydrogels for combined immuno-chemotherapy - Journal of Controlled Release - 2017 - 255, 81-93
28) Injectable polypeptide hydrogel as biomimetic scaffolds with tunable bioactivity and controllable cell adhesion - Biomacromolecules - 2017 - 18, 1411-1418
29) Injectable Thermo-Sensitive Polypeptide-based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy - Biomacromolecules - 2017 - 18, 4341-4348
30) Enzymatically Crosslinked Hydrogels based on Linear Poly(ethylene glycol) Polymer: Performance and Mechanism. - Polymer Chemistry - 2017 - 8, 7017-7024
31) Co-delivery of chemotherapeutics and proteins for synergistic therapy - Advanced Drug Delivery Reviews - 2016 - 98, 64-76
32) Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model - Biomaterials - 2016 - 75, 148-162
33) Thermosensitive polypeptide hydrogels as a platform for ROS-triggered cargo release with innate cytoprotective ability under oxidative stress - Advanced Healthcare Materials - 2016 - 5, 1979-1990
34) Injectable, biomolecule-responsive polypeptide hydrogels for cell encapsulation and facile cell recovery through triggered degradation - ACS Applied Materials & Interfaces - 2016 - 8, 30692-30702
35) Injectable polypeptide hydrogels with tunable microenvironment for 3D spreading and chondrogenic differentiation of bone marrow-derived mesenchymal stem cells - Biomacromolecules - 2016 - 17, 3862-6871
36) Reactive oxygen species (ROS) responsive polymers for biomedical applications - Macromolecular Bioscience - 2016 - 16, 635-646
37) Injectable glycopolypeptide hydrogels as biomimetic scaffolds for cartilage tissue engineering - Biomaterials - 2015 - 51, 238-249
38) ε-methacryloyl-L-Lysine based polypeptides and their thiol-ene click functionalization - Polymer Chemistry - 2015 - 6, 1758-1767
39) Nanogel-incorporated physical and chemical hybrid gels for highly effective chemo-protein combination therapy - Advanced Functional Materials - 2015 - 25, 6744-6755
40) Injectable enzymatically crosslinked hydrogels based on a poly(L-glutamic acid) graft copolymer - Polymer Chemistry - 2014 - 5, 5069-5076
41) Disulfide cross-linked polyurethane micelles as a reduction-triggered drug delivery system for cancer therapy - Advanced Healthcare Materials - 2014 - 3, 752-760
42) Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs - Biomaterials - 2013 - 34, 10338-10347
43) Stimuli-sensitive synthetic polypeptide-based materials for drug and gene delivery - Advanced Healthcare Materials - 2012 - 1, 48-78
 
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