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郑基深
单位:生命科学学院
地址:安徽合肥蜀山区黄山路443号中科大生命学院附楼905
邮编:230027
电话:055163607782
个人主页:
实验室介绍: https://biox.ustc.edu.cn/2018/0629/c692a470372/page.htm
 
个人简历 Personal resume
    郑基深,中国科学技术大学生命科学与医学部/微尺度物质科学国家研究中心教授,中国科大附属第一医院特聘专家,国家优秀青年基金获得者,获得基金委重大研究计划、科技部重点研发计划和科技创新特区等多项国家级课题。在J Am Chem Soc、Angew Chem Int Ed、Nature Protocols、Acc Chem Res和Sci China Chem等国内外高水平杂志发表通讯作者论文30余篇。
    研究方向是蛋白质合成生物学,用于生物学、药学、生物医学等。(1)发展生物/化学/人工智能等多学科交叉的蛋白功能进化新技术;(2)发现多肽和蛋白类药物分子(例如新型抗体偶联药物);(3)开发基于生物大分子的医用材料和信息存储材料。
 
研究方向 Research direction
1、蛋白质功能进化/合成生物学
2、蛋白质药物/噬菌体筛选/化学生物学
3、蛋白质生物医用材料/信息材料
 
招生信息 Enrollment information
(1)具有浓厚的科学研究兴趣,有志于从事科研工作;
(2)对未知问题充满好奇心和想象力;
(3)具备勇于攻坚克难的勇气和毅力。
 
论文专著 The monograph
1) Montigny, C.; Huang, D. L.; Beswick, V.; Barbot, T.; Jaxel, C.; le Maire, M.; Zheng, J. S.*; Jamin, N., Sarcolipin alters SERCA1a interdomain communication by impairing binding of both calcium and ATP. - Sci Rep 2021, 11 (1), 1641. - -
2) The New Salcylaldehyde S,S-Propanedithioacetal Ester Enables N-to-C Sequential Native Chemical Ligation and Ser/Thr Ligation for Chemical Protein Synthesis. - J. Am. Chem. Soc. 2020 142 (19), 8790-8799. - -
3) Synthesis of disulfide surrogate peptides incorporating large-span surrogate bridges through a native chemical ligation-assisted diaminodiacid strategy. - Angew. Chem. Int. Ed. 2020, 59 (15), 6037-6045. - -
4) Chemical Synthesis of Native S-palmitoylated Membrane Proteins through Reversible Backbone Modification Assisted Ser/Thr Ligation. - Angew. Chem. Int. Ed. 2020, 59 (13), 5178-5184. - -
5) Li, Y.; Cao, X.; Tian, C.; Zheng, J. S.*, Chemical protein synthesis-assisted high-throughput screening strategies for d-peptides in drug discovery. - Chinese Chemical Letters 2020, 31 (9), 2365-2374. - -
6) Ligation of Soluble but Unreactive Peptide Segments in the Chemical Synthesis of Haemophilus Influenzae DNA Ligase. - Angew. Chem. Int. Ed. 2019, 58, 12231-12237. - -
7) Qi, Y.-K.*; Si, Y.-Y.; Du, S.-S.; Liang, J.; Wang, K.-W.*; Zheng, J. S.*, Recent advances in the chemical synthesis and semi-synthesis of poly-ubiquitin-based proteins and probes. - Science China Chemistry 2019, 62 (3), 299-312. - -
8) 8. Guo, Q. Y.; Zhang, L. H.; Zuo, C.; Huang, D. L.; Wang, Z. A.; Zheng, J. S.*; Tian, C. L.*, Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors. - Protein Cell 2019, 10, 211-216. - -
9) Zuo C.; Zhang B.; Yan B.; Zheng, J. S.*, One-pot multi-segment condensation strategies for chemical protein synthesis. - Org Biomol Chem 2019, 17, 727-744. - -
10) Liang, L.-J.; Si, Y.; Tang, S.; Huang, D.; Wang, Z. A.; Tian, C.; Zheng, J. S.*, Biochemical properties of K11,48-branched ubiquitin chains. - Chinese Chemical Letters 2018, 29, 1155-1159. - -
11) Tang, S.; Liang, L. J.; Si, Y. Y.; Gao, S.; Wang, J. X.; Liang, J.; Mei, Z.; Zheng, J. S.*; Liu, L.* Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide-Linked Ub Isomer. - Angew. Chem. Int. Ed. 2017, 56, 13333-13337. - -
12) Tang, S.; Zuo, C.; Huang, D. L.; Cai, X. Y.; Zhang, L. H.; Tian, C. L.*; Zheng, J. S.*; Liu, L.* Chemical Synthesis of Membrane Proteins via the Removable Backbone Modification Method. - Nat. Protoc. 2017, 12, 2554-2569. - -
13) Li, J. B.#; Tang, S.#; Zheng, J. S.*; Tian, C. L.*; Liu, L.* Removable Backbone Modification Method for the Chemical Synthesis of Membrane Proteins. - Acc. Chem. Res. 2017, 50, 1143-1153. - -
14) Chemical Synthesis of K34-Ubiquitylated H2B for Nucleosome Reconstitution and Single-Particle Cryo-Electron Microscopy Structural Analysis. - ChemBioChem 2017, 18, 176-180. - -
15) Zuo, C.; Tang, S.; Si, Y.-Y.; Wang, Z.-A.; Tian, C.-L.; Zheng, J.-S.* Efficient synthesis of longer Aβ peptides via removable backbone modification. - Org Biomol Chem 2016, 14, 5012-5018. - -
16) Qi Y.-K.; Tang, S.; Huang, Y.-C.; Pan, M.; Zheng, J.-S.* Liu, L.* Hmb(off/on) as a switchable thiol protecting group for native chemical ligation. - Org Biomol Chem 2016, 14, 4194. - -
17) Zheng, J. S.#; He, Y.#; Zuo, C.; Cai, X. Y.; Tang, S.; Wang, Z. A.; Zhang, L. H., Tian, C. L.*; Liu, L.* Robust Chemical Synthesis of Membrane Proteins through a General Method of Removable Backbone Modification. - J. Am. Chem. Soc. 2016, 138, 3553-3561. - -
18) Chen, X.#; Tang, S.#; Zheng, J. S.#; Zhao, R.; Wang, Z. P.; Shao, W.; Chang, H. N.; Cheng, J. Y.; Zhao, H.; Liu, L.*; Qi, H.* Chemical Synthesis of a Two-Photon-Activatable Chemokine and Photon-Guided Lymphocyte Migration in vivo. - Nat. Commun. 2015, 6, 7220-7228. - -
19) Zheng, J. S.; Yu, M.; Qi, Y. K.; Tang, S.; Shen, F.; Wang, Z. P.; Xiao, L.; Zhang, L.; Tian, C. L.*; Liu, L.* Expedient Total Synthesis of Small to Medium-Sized Membrane Proteins via Fmoc Chemistry. - J. Am. Chem. Soc. 2014, 136, 3695-3704. - -
20) Zheng, J.-S.; Tang, S.; Qi, Y.-K.; Wang, Z.-P.; Liu, L.* Chemical Synthesis of Proteins Using Peptide Hydrazides as Thioester Surrogates. - Nat. Protoc. 2013, 8, 2483-2495. - -
21) Zheng, J.-S.; Tang, S.; Huang, Y.-C.; Liu, L.* Development of New Thioester Equivalents for Protein Chemical Synthesis. - Acc. Chem. Res. 2013, 46, 2475–2484. - -
22) Zheng, J.-S.; Chang, H.-N.; Wang, F.-L.; Liu, L.* Fmoc Synthesis of Peptide Thioesters without Post-Chain-Assembly Manipulation. - J. Am. Chem. Soc. 2011, 133, 11080-11083. - -
 
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