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唐丽琴
单位:附属第一医院
地址:合肥市庐阳区庐江路17号
邮编:230001
电话:86-551-62283378-809
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个人简历 Personal resume
    医学博士,教授/主任药师,博士生导师,安徽省学术技术带头人后备人选,安徽省卫计委青年领军人才,附一院首批青年技术骨干和第二届杰出技术骨干,临床药学教研室主任、药剂科副主任。主持课题16项(其中国家自然科学基金3项),以第一/通讯作者发表论文四十余篇(其中SCI论文18篇),参编论著4部,获安徽省科技成果1项,主持开展院三新项目7项。是国家卫健委精准医疗远程会诊专家委员会委员、国家自然科学基金通讯评审专家、国家执业药师工作专家、中国药学会循证药学专委会委员、安徽省药学会常务理事、安徽省药学会药物经济学专委会副主任委员。
   目前重点进行代谢性疾病的分子机制研究。近年来,坚持将基础研究与应用研究紧密结合,在糖尿病及其并发症的发病机理和相关分子机制、药物治疗新靶点等方面进行了深入探索。本人带领的研究团队,重点从糖尿病肾病的炎症免疫机制着手,以肾小球系膜细胞和足细胞为靶细胞,从分子水平研究疾病状态下的非编码RNA、相关信号通路的变化及其对细胞功能和疾病进程的影响,探讨糖尿病肾病的发病机制;并通过传统中药黄连及其有效成分小檗碱对糖尿病肾病的作用研究,为筛选新的糖尿病肾病治疗药物和寻找新的药物作用靶点提供技术平台。
 
研究方向 Research direction
1、医学分子生物学
2、细胞免疫、分子机制与药物治疗
 
招生信息 Enrollment information
执行中科大博士生录取标准,不附加其他条件。
 
论文专著 The monograph
1) Renoprotective effect of berberine via regulating the PGE 2-EP1-Gαq-Ca2+ signalling pathway in glomerular mesangial cells of diabetic rats - J Cell Mol Med - 2016 - 20(8):1491-1502
2) Roles of the NLRP3 in the pathogenesis of diabetic nephropathy - Pharmacological Research - 2016 - 114: 251-264
3) Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy - Molecular and Cellular Endocrinology - 2017 - 443:89-105
4) Berberine attenuates podocytes injury caused by exosomes derived from high glucose-induced mesangial cells through TGFβ1-PI3K/AKT pathway - Eur J Pharmacol - 2018 - 824:185-192
5) Renoprotective effects of berberine and its potential effect on the expression of β-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in streptozocin-diabetic nephropathy rats - J Diabetes - 2016 - 8(5):693-700
6) Research progress in signalling pathway in diabetic nephropathy - Diabetes Metab Res Rev - 2015 - 31(3):221-33
7) Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms - Eur J Pharmacol - 2015 - 760:103-112
8) Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats - Eur J Pharmacol - 2015 - 764:448-456
9) G protein-coupled receptors: potential therapeutic targets for diabetic nephropathy - J Recept Signal Transduct - 2015 - 16:1-11
10) Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy - Molecular Biology Reports - 2014 - 41(5):3339-3347
11) The renoprotective effects of berberine via the EP4-Gαs-cAMP signaling pathway in different stages of diabetes in rats - J Recept Signal Transduct - 2014 - 34(6):445-455
12) Berberine ameliorates renal injury by regulating G proteins-AC- cAMP signaling in diabetic rats with nephropathy - Molecular Biology Reports - 2013 - 40(6):3913-3923
13) Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats - Molecular Biology Reports - 2013 - 40(3):2405-2418
14) Prostanoids receptors signaling in different diseases/cancers progression - J Recept Signal Transduct - 2013 - 33(1):14-27
15) The connection between GRKs and various signaling pathways involved in Diabetic nephropathy - Molecular Biology Reports - 2012 - 39(7):7717-7726
16) Effects and mechanisms of catechin on adjuvant arthritis in rats - Advance in therapy - 2007 - 24(3):679-690
17) Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats - Journal of Ethnopharmacology - 2006 - 108:109-115
 
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