特任研究员，博士生导师
1997年至2001年就读于浙江大学生命科学学院，获得生物化学理学学士学位。2001年至2009年就读于中国科学院上海生物化学与细胞生物学研究所，获得生物化学与分子生物学理学博士学位。 2009年至2011年期间，在美国俄亥俄州立大学医学中心从事博士后研究工作。2011年至2018年期间，在美国克利夫兰医学中心从事博士后研究工作。2018年12月加入中国科技大学，双聘于生命科学学院与附属第一医院。主要从事胶质瘤干细胞(glioma stem cell, GSC) 和肿瘤微环境的相关研究。研究领域包括肿瘤免疫、肿瘤血管生成、肿瘤干细胞特异性调节分子等。在肿瘤免疫微环境研究方向，发现胶质瘤干细胞可以通过分泌POSTN蛋白来促进巨噬细胞对肿瘤的浸润，而巨噬细胞进一步支持肿瘤恶性发展，二者形成一个恶性正反馈调节回路促进肿瘤发展。在肿瘤血管系统研究方向，发现肿瘤血管周细胞来源于胶质瘤干细胞，而周细胞覆盖于血管内皮细胞，决定了血癌屏障以及药物传递效率，是化学治疗的关键靶点。在Cell, Cell Stem Cell, Nature Cell Biology, Science Translational Medicine等杂志发表论文20余篇，包括2篇ESI高引用论文。
主要研究方向：
1. 胶质瘤干细胞与肿瘤相关的巨噬细胞相互作用的分子机制
2. 胶质瘤肿瘤血管周细胞的分化与维持的分子调控机制
3. 胶质瘤干细胞干性维持相关的信号通路
代表性论文：
1. Yu Shi, Olga A. Guryanova, Wenchao Zhou, Chong Liu, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Cong Chen, Qiulian Wu, Zhicheng He, Wei Wang, Wei Zhang, Tao Jiang, Qing Liu, Yaping Chen, Wenying Wang, Jingjing Wu, Leo Kim, Ryan C. Gimple, Hua Feng, Hsiang-Fu Kung, Jennifer S. Yu, Jeremy N. Rich, Yi-Fang Ping#, Xiu-Wu Bian,# and Shideng Bao#. Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance. Sci Transl Med. 2018 May 30;10(443). pii: eaah6816. doi: 10.1126/scitranslmed.aah6816.
2. Jianghong Man*, Xingjiang Yu*, Haidong Huang, Wenchao Zhou, Chaomei Xiang, Haohao Huang, Lucio Miele, Zhenggang Liu, Gurkan Bebek, Shideng Bao, Jennifer S. Yu. Hypoxic induction of Vasorin regulates Notch1 turnover to maintain glioma stem-like cells. Cell Stem Cell. 2018 Jan 4;22(1):104-118.
3. Wenchao Zhou, Cong Chen, Yu Shi, Qiulian Wu, Ryan C. Gimple, Xiaoguang Fang, Zhi Huang, Kui Zhai, Susan Q. Ke, Yi-Fang Ping, Hua Feng, Jeremy N. Rich, Jennifer S. Yu, Shideng Bao, and Xiu-Wu Bian. Targeting glioma stem cell-derived pericytes disrupts the blood-tumor barrier and improves chemotherapeutic efficacy. Cell Stem Cell. 2017 Nov;21 (5): 591-603. (Featured Article)
4. Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xianchao Zhang, Kai Zhou, Qing Liu, Hua Long, Tiwei Fu, Xiao-Ning Zhang, Mianfu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng, Xiao-Hong Yao, Shi-Cang Yu, You-Hong Cui, Xia Zhang, Jeremy N. Rich, Shideng Bao & Xiu-Wu Bian. Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signaling in glioblastoma stem cells for tumour growth. Nat Commun. 2017 Jun 1; 8: 15080.
5. Yu Shi, Wenchao Zhou, Lin Cheng, Cong Chen, Zhi Huang, Xiaoguang Fang, Qiulian Wu, Zhicheng He, Senlin Xu, Justin D Lathia, Yifang Ping, Jeremy N Rich, Xiu-Wu Bian, and Shideng Bao. Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells. Cell Death Differ. 2017 Jan;24(1):167-180.
6. Xiaoguang Fang, Wenchao Zhou, Qiulian Wu, Zhi Huang, Yu Shi, Kailin Yang, Cong Chen, Qi Xie, Stephen C Mack, Xiuxing Wang, Angel M Carcaboso, Andrew E Sloan, Gaoliang Ouyang, Roger E McLendon, Xiu-wu Bian, Jeremy N Rich, and Shideng Bao. Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. J Exp Med. 2017 Jan;214(1):245-267.
7. Wenchao Zhou, Lin Cheng, Yu Shi, Susan Q. Ke, Zhi Huang, Xiaoguang Fang, Cheng-wei Chu, Qi Xie, Xiu-wu Bian, Jeremy N. Rich, Shideng Bao. Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth. Oncotarget. 2015 Nov 10;6(35):37300-15.
8. Qi Xie, Qiulian Wu, Craig M Horbinski, William A Flavahan, Kailin Yang, Wenchao Zhou, Stephen M Dombrowski, Zhi Huang, Xiaoguang Fang, Yu Shi, Ashley N Ferguson, David F Kashatus, Shideng Bao, Jeremy N Rich. Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci. 2015 Apr;18(4):501-10.
9. Wenchao Zhou, Susan Q. Ke, Zhi Huang, William Flavahan, Xiaoguang Fang, Jeremy Paul, Ling Wu, Andrew E. Sloan, Roger E. McLendon, Xiaoxia Li, Jeremy N. Rich, and Shideng Bao. Periostin secreted by glioblastoma stem cells recruits M2 tumor-associated macrophages and promotes malignant growth. Nat Cell Biol. 2015 Feb;17(2):170-82. (ESI Highly Cited Papers)
10. Jianghong Man, Jocelyn Shoemake, Wenchao Zhou, Xiaoguang Fang, Qiulian Wu, Anthony Rizzo, Richard Prayson, Shideng Bao, Jeremy N. Rich, Jennifer S. Yu. Sema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation. Cell Rep. 2014 Dec 11;9(5):1812-26.
11. Xiaoguang Fang, Zhi Huang, Wenchao Zhou, Qiulian Wu, Andrew E. Sloan, Gaoliang Ouyang, Roger E. McLendon, Jennifer S. Yu, Jeremy N. Rich, and Shideng Bao. The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells. Stem cells. 2014 Aug;32(8):2033-47.
12. Wenchao Zhou and Shideng Bao. Reciprocal supportive interplay between glioblastoma and tumor-associated macrophages. Cancers (Basel). 2014 Mar 26;6(2):723-40.
13. Wenchao Zhou and Shideng Bao. PML-mediated signaling and its role in cancer stem cells. Oncogene. 2014 Mar 20;33(12):1475-84.
14. Lin Cheng*, Zhi Huang*, Wenchao Zhou, Qiulian Wu, Shannon Donnola, James K. Liu, Xiaoguang Fang, Andrew E. Sloan, Yubin Mao, Justin D. Lathia, Wang Min, Roger E. McLendon, Jeremy N. Rich, and Shideng Bao. Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell. 2013 Mar 28;153(1):139-52. (ESI Highly Cited Papers)
15. Flavia Pichiorri, Sung-Suk Suh, Alberto Rocci, Luciana De Luca, Cristian Taccioli, Santhanam Ramasamy, Wenchao Zhou, Don Benson, Craig Hofmainster, Hansjuerg Alder, Michela Garofalo, Giampiero Di Leva, Stefano Volinia, Huey-Jen Lin, Danilo Perrotti, Michael Kuehl, Rami I. Aqeilan, Antonio Palumbo, and Carlo M. Croce. Down-regulation of p53-inducible microRNAs 192, 194 and 215 impairs p53/HDM2 auto-regulatory loop in multiple myeloma development. Cancer Cell. 2010 Oct; 18 (4): 367-81.
16. Wenchao Zhou, Xiujing Feng, Yingjie Wu, Johannes Benge, Zhe Zhang and Zhengjun Chen. FGF-receptor substrate2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway. Cell Research. 2009 Oct; 19(10): 1165-77.
17. Xiujing Feng, Xuefen Lu, Xiaobo Man, Wenchao Zhou, Lake Qunfeng Jiang, Pejte Knyyazev, Axel Ullrich, Zhe Zhang and Zhengjun Chen. Overexpression of Csk-binding protein contributes to renal cell carcinogenesis. Oncogene. 2009 Sep; 28(37): 3320-31.
招生招聘：
实验室招聘副研究员、助理研究员，常年招收博士后和研究生，享受中国科学技术大学及附属第一医院相关福利待遇。同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读硕博士学位。
联系方式：wzaz@ustc.edu.cn