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王均
单位:生命科学学院
地址:安徽省合肥市黄山路443号中国科学技术大学生命科学院大楼215室
邮编:230026
电话:+86-551-63600335
个人主页: http://nanomedicine.ustc.edu.cn/syscy_1/wjjs/201405/t20140516_196194.html
实验室介绍: http://nanomedicine.ustc.edu.cn/
 
个人简历 Personal resume
王 均   1993年于武汉大学获化学专业和细胞生物学专业学士学位;1999年1月于武汉大学获高分子化学和物理专业博士学位;1994年在北京大学医学部(原北京医科大学)药学院天然与仿生药物国家重点实验室从事高分子免疫佐剂的开放课题研究;1999年5月至2004年6月先后在约翰霍普金斯医学院新加坡生命医学中心(Johns Hopkins Singapore)、美国约翰霍普金斯大学医学院生物医学工程系从事博士后研究;2004年9月,入选中国科学院“百人计划—引进国外杰出人才”,任中国科学技术大学高分子科学与工程系教授,博士生导师,2006年获“百人计划”择优支持;2006年7至8月,德国罗斯托克大学医学院访问教授;2006年12月起任中国科学技术大学生命科学学院教授、博士生导师,合肥微尺度物质科学国家实验室研究员;2011年获国家杰出青年科学基金资助。目前任中国生物材料协会理事,中国化学会化学生物学专业委员会委员,中国微纳协会纳米生物与医药技术专业委员会委员,Biomaterials Science杂志(英国皇家化学会)编委;在Science Translational Medicine、Angew Chem Int Ed、J Am Chem Soc、Advanced Materials、ACS Nano、J Controlled Release、Biomaterials等杂志发表研究论文110余篇,参与撰写英文专著章节三篇,论文被引用3900余次;授权中国发明专利6项,美国发明专利1项。实验室已毕业博士研究生12人,指导博士研究生中5位获中国科学院院长优秀奖,2位获“求是”优秀研究生奖,5位获朱李月华优秀博士生奖,2009~2012年实验室研究生连续4年获GE基金会科技创新奖(其中2次一等奖,2次二等奖,一次三等奖),2位研究生获得2010年度校级学术新人奖,1位获2011年度教育部学术新人奖。
 
研究方向 Research direction
1、肿瘤靶向治疗/肿瘤干细胞/纳米药物/RNA干扰
2、生物材料/药物递送系统
3、生物医学工程
 
招生信息 Enrollment information
仅招收硕博连读生, 生物学、药学、高分子化学与物理、医学背景学生
 
论文专著 The monograph Researcher ID
1) Enhancement of Lipopolysaccharide-Induced Nitric Oxide and Interleukin-6 Production by PEGylated Gold Nanoparticles in RAW264.7 Cells - Nanoscale - 2012 - 4, 7135-7142
2) Therapeutic Delivery of siRNA Silencing HIF-1 Alpha with Micellar Nanoparticles Inhibits Hypoxic Tumor Growth - Molecular Pharmaceutics - 2012 - 9, 2863-2874
3) In Vitro and In Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles - Advanced Materials - 2012 - 24, 5586-5592
4) Bacteria-Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery - Advanced Materials - 2012 - 24, 6175-6180
5) Surface Charge Switchable Nanoparticles based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor - Advanced Materials - 2012 - 24, 5476-5480
6) Anti-Her2 Single-Chain Antibody Mediated DNMTs-siRNA Delivery for Targeted Breast Cancer Therapy - Journal of Controlled Release - 2012 - 161, 875-883
7) Combating the Drug Resistance of Cisplatin Using a Platinum Prodrug Based Delivery System - Angewandte Chemie-International Edition - 2012 - 51, 6742-6747
8) Single-Step Assembly of Cationic Lipid-Polymer Hybrid Nanoparticles for Systemic Delivery of siRNA - ACS Nano - 2012 - 6, 4955-4965
9) Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis - Science Translational Medicine - 2012 - 4, 130ra48
10) The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency - Macromolecular Bioscience - 2012 - 12, 666-674
11) Biocompatible and Functionalizable Polyphosphate Nanogels with A Branched Structure - Journal of Materials Chemistry - 2012 - 22, 9322-932
12) Lipase-Sensitive Polymeric Triple-Layered Nanogel for “On-Demand” Drug Delivery - Journal of the American Chemical Society - 2012 - 134, 4355-4362
13) Sheddable Ternary Nanoparticles for Tumor Acidity-Targeted siRNA Delivery - ACS Nano - 2012 - 6, 771-781
14) Micelle-to-Vesicle Morphological Transition via Light-Induced Rapid Hydrophilic Arm Detachment from a Star Polymer - Chemical Communications - 2012 - 48, 1257-1259
15) Two Consecutive Click Reactions as a General Route to Functional Cyclic Polyesters - Chemical Communications - 2012 - 48, 570-572
16) Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery - Journal of the American Chemical Society - 2011 - 133, 17560-17563
17) Pivotal Role of Reduced Let-7g Expression in Breast Cancer Invasion and Metastasis - Cancer Research - 2011 - 71, 6463-6474
18) Redox-Responsive Nanoparticles from the Single Disulfide Bond-Bridged Block Copolymer as Drug Carriers for Overcoming Multi-Drug Resistance in Cancer Cells - Bioconjugate Chemistry - 2011 - 22, 1939-1945
19) Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy - Journal of Controlled Release - 2011 - 156, 203-211
20) Nanofiber-Mediated Controlled Release of siRNA Complexes for Long Term Gene-Silencing Applications - Biomaterials - 2011 - 32, 5915-5923
21) Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells - ACS Nano - 2011 - 5, 3679-3692
22) Multiple Functional Hyperbranched Poly(amido amine) Nanoparticles: Synthesis and Application in Cell Imaging - Biomacromolecules - 2011 - 12, 1523-1531
23) A Biodegradable Amphiphilic and Cationic Triblock Copolymer for the Delivery of siRNA Targeting the Acid Ceramidase Gene for Cancer Therapy - Biomaterials - 2011 - 32, 3124-3133
24) Phosphoester modified poly(ethylenimine) as efficient and low cytotoxic genevectors - Science China Chemistry - 2011 - 54, 351-358
25) Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression - ACS Nano - 2011 - 5, 1483-1494
26) Targeted delivery of antisense inhibitor of miRNA for antiangiogenesis therapy using cRGD-functionalized nanoparticles - Molecular Pharmaceutics - 2011 - 8, 250-259
27) Syntheses and Characterization of Block Copolymers of Poly(aliphatic ester) with Clickable Polyphosphoester - J Polymer Science Part A: Polymer Chemisty - 2011 - 49, 487-494
28) Temperature-Induced Morphological Changes of ABC 3-Miktoarm Star Terpolymer Assemblies in Aqueous Solution - Colloid and Surface B: Biointerfaces - 2011 - 85, 81-85
29) Gold Nanorods for Platinum Based Prodrug Delivery - Chemical Communications - 2010 - 46, 8424-8426
30) Poly(ε-caprolactone)-Block-poly(ethyl Ethylene Phosphate) Micelles for Brain Targeting Drug Delivery: In Vitro and In Vivo Valuation - Pharmaceutical Research - 2010 - 27, 2657-2669
31) Electrosprayed core-shell microspheres for protein delivery - Chemical Communications - 2010 - 46, 4743-4
32) Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery - Chem. Commun - 2010 - 46, 3520–3522
33) Brush-shaped polycation with poly(ethylenimine)-b-poly(ethylene glycol) side chains as highly efficient gene delivery vector - International Journal of Pharmaceutics - 2010 - 392, 118–126
34) A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery - Angew. Chem. Int. Ed - 2010 - 49, 3621 –3626
35) Core–Shell–Corona Micelle Stabilized by Reversible Cross-Linkage for Intracellular Drug Delivery - Macromol. Rapid Commun - 2010 - 31, 1201–1206
36) Localized SDF-1alpha Gene Release Mediated by Collagen Substrate Induces CD117+ Stem Cell Homing - Journal of Cellular and Molecular Medicine - 2010 - 14, 392-402
37) One-Pot Syntheses of Amphiphilic Centipede-like Brush Copolymers via Combination of Ring-Opening Polymerization and “Click” Chemistry - Macromolecules - 2010 - 43, 1739-1746
38) Cytotoxicity and Cellular Uptake of Iron Nanowires - Biomaterials - 2010 - 7, 1509-1517
39) Gold Nanoparticles Capped with Polyethyleneimine for Enhanced siRNA Delivery - small - 2010 - 6, 239–246
40) Recent Progress in Polyphosphoesters:From Controlled Synthesis to Biomedical Applications - Macromolecular Bioscience - 2009 - 9, 1154–1164
41) Template-free synthesis of biodegradable nanogels with tunable sizes as potential carriers for drug delivery - Journal of Materials Chemistry - 2009 - 19, 7856–7863
42) Biodegradable vesicular nanocarriers based on poly(3-caprolactone)-block-poly(ethyl ethylene phosphate) for drug delivery - Polymer - 2009 - 50, 5048–5054
43) Localized and Sustained SDF-1 Gene Release Mediated by Fibronectin Films: A Potential Method for Recruiting Stem Cells - International Journal of Artificial Organs - 2009 - 32, 141-149
44) Synthesis and Thermoresponsive Behaviors of Biodegradable Pluronic Analogs - Journal of Polymer Science: Part A: Polymer Chemis - 2009 - 47, 6168-6179
45) Gold Nanoparticles Stabilized by Thermosensitive Diblock Copolymers of Poly(ethylene glycol) and Polyphosphoester - Langmuir - 2009 - 25(17), 10298–10304
46) Evaluation of Polymeric Micelles from Brush Polymer with Poly(epsilon-caprolactone)-b-Poly(ethylene glycol) Side Chains as Drug Carrier - Biomacromolecules - 2009 - 10, 2169-2174
47) Syntheses of Amphiphilic Biodegradable Copolymers of Poly(ethyl ethylene phosphate) and Poly(3-hydroxybutyrate) for Drug Delivery - Science in China Series B: Chemistry - 2009 - 52,961-968
48) Block Copolymer of Polyphosphoester and Poly(L-Lactic Acid) Modified Surface for Enhancing Osteoblast Adhesion, Proliferation, and Function - Biomacromolecules - 2009 - 10, 2213–2220
49) Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery - Bioconjugate Chemistry - 2009 - 20, 1095-1099
50) Tunable Thermosensitivity of Biodegradable Polymer Micelles of Poly(ε-caprolactone) and Polyphosphoester Block Copolymers - MACROMOLECULES - 2009 - 42, 3026-3032
51) Synthesis of PEG-Armed and Polyphosphoester Core-Cross-Linked Nanogel by One-Step Ring-Opening Polymerization - MACROMOLECULES - 2009 - 42, 893-896
52) Thermoresponsive Block Copolymers of Poly(ethylene glycol) and Polyphosphoester: Thermo-Induced Self-Assembly, Biocompatibility and Hydrolytic Degradation - BIOMCROMOLECULES - 2009 - 10, 66-73
53) Synthesis of Amphiphilic ABC 3-Miktoarm Star Terpolymer by Combination of Ring Opening Polymerization and “Click” Chemistry - MACROMOLECULES - 2008 - 41, 8620-8625
54) Synthesis and Characterization of Star-Shaped Block Copolymer of Poly(epsilon-caprolactone) and Poly(ethyl ethylene phosphate) as Drug Carrier - Polymer - 2008 - 49, 4784-4790
55) Functionalized Diblock Copolymer of Poly(ε-caprolactone) and Polyphosphoester Bearing Hydroxyl Pendent Groups: Synthesis, Characterization and Self-Assembly - MACROMOLECULES - 2008 - 41, 6935-6941
56) Synthesis and Characterization of Amphiphilic Block Copolymer of Polyphosphoester and Poly(L-lactic acid) - Journal of Polymer Science Part A: Polymer Chemist - 2008 - 46, 6425-6434
57) Self-Assembled Biodegradable Micellar Nanoparticles of Amphiphilic and Cationic Block Copolymer for siRNA Delivery - Biomaterials - 2008 - 29, 4348-4355
58) Functionalized Micelles from Block Copolymer of Polyphosphoester and Poly(epsilon-caprolactone) for Receptor-Mediated Drug Delivery - Journal of Controlled Release - 2008 - 128, 32-40
59) Biodegradable Polycation and Plasmid DNA Multilayer Film for Prolonged Gene Delivery to Mouse Osteoblasts - Biomaterials - 2008 - 29,733-741
60) Self-assembled Micelles of Biodegradable Triblock Copolymers Based on Poly(ethyl ethylene phosphate) and Poly(epsilon-caprolactone) as Drug Carriers - Biomacromolecules - 2008 - 9, 388-395
61) Synthesis and Characterization of Photocrosslinked Hydrogel Based on Biodegradable Polyphosphoester and Poly(ethylene glycol) Copolymer - Biomacromolecules - 2007 - 8, 3375-3381
62) Block Copolymerization of ε-Caprolactone and 2-Methoxyethyl Ethylene Phosphate Initiated by Aluminum Isopropoxide: Synthesis, Characterization, and Kinetics - Macromolecules - 2006 - 39, 8992-8998
63) Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate - Macromolecules - 2006 - 39, 6825-6831
64) Synthesis and Micellization of Amphiphilic Brush-Coil Block Copolymer Based on Poly(ε-caprolactone) and PEGylated Polyphosphoester - Biomacromolecules - 2006 - 7, 1898-1903
65) Synthesis and Characterization of Block Copolymer of Polyphosphoester and Poly(epsilon-caprolactone) - Macromolecules - 2006 - 39, 473-475
66) Biodegradable and photocrosslinkable polyphosphoester hydrogel - Biomaterials - 2006 - 27, 1027-1034
67) Regulating the surface poly(ethylene glycol) density of polymeric nanoparticles and evaluating its role in drug delivery in vivo - Biomaterials - 2015-8 - 2015年
 
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