Faculty Profile
  SHI Yunyu
Department: School of Life Science
Mailing Address:
School of Life Science,University of Science and Technology of China, 443 Huangshan Rd, Hefei, Anhui, PR China
Postal Code:

Research Profile

    Shi Yunyu, female, professor and academician of the Chinese Academy of Sciences, was born in April 1942.
In 1965 she graduated from Specialty of Biophysics, Department of Physics, University of Science and Technology of China (USTC). From 1965 to 1970, she served as assistant researcher at Academy of Traditional Chinese Medicine, Ministry of Health of PRC; since 1970, she has been serving as teaching assistant, lecturer, associate professor and professor at USTC. She once went to University of Rome, Institute of Structural Chemistry of National Centre for Scientific Research of France, University of Groningen, and Laboratory for Structural Biology and Laboratory for Theoretical Chemistry of National Centre for Scientific Research of France for further study and cooperative research. She has published more than 100 papers in international high-level academic journals. At present she holds the position of standing member of Committee of Division of Biology and Medicine of CAS, chairman of Teaching Guiding Committee for Biological Science and Engineering Higher Education Institutions of Ministry of Education, and deputy director of Academic Committee of USTC.
Main Research Interests: 
Multidimensional NMR spectra and computational biology have been adopted to study protein structures related to major diseases or physiological function, relationship between dynamics and functions, and interactions among proteins, nucleic acid and ligand.
Main Current Research Projects:
Projects under “973 Program” and National Natural Science Foundation of China
Selected Publications
1) Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex , Protein Science , 2007 , 16:1053-1062
2) Investigation of the Structural Stability of hUBF HMG Box 5 by Native-State Hydrogen Exchange , Biochemistry , 2007 , 46 (5), 1293 -1302
3) Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin , Protein Science , 2006 , 15(9):2149-58
4) Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from neurexin and Bcr , J Biol Chem , 2005 , 280(14):13841-13847
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