Jiang-Ning Zhou Ph D
Prof. of Neurobiology
Vice dean of School of Life Science
University of Science and Technology of China
School of Life Sciences
96 Jinzhai Road
Hefei, Anhui, 230026, China
My laboratory pursues two lines of research which are funded by the Ministry of Science and Technology of China and Nature Science Foundation of China. In the first project, we are interested in how the interaction between ApoE gene and environment factors be involved in the pathogenesis of Alzheimer’s disease. In the second project, we are studying the mechanism of multiple receptors regulate the activity of corticotrophin releasing hormone neurons in hypothalamus in stress response and depression. The aim of both research lines is to find putative factors and targets for therapeutic strategies. Several experimental approaches are used in these research, including behavioral, microdialysis in free running animal, cell culture, patch clamp electrophysiology, and a variety of molecular and biochemical techniques. Our work on the human hypothalamus is carried out in collaboration with Prof. Swaab in the Netherlands Institute for Neuroscience.
1) Chen XN, Meng QY, Bao AM, Swaab DF, Wang GH, Zhou JN.2009. The involvement of retinoic acid receptor-α in corticotropin-releasing hormone gene expression and affective disorders. Biological Psychiatry published online doi:10.1016/j.biopsych.
2) Wang SS, Willem Kamphuis, Inge Huitinga, Zhou JN, D.F. Swaab. 2008. Gene Expression Analysis in the Human Hypothalamus in Depression by Laser Micro-Dissection and Real Time PCR: the presence of multiple receptor imbalances. Molecular Psychiatry. 13:786-99.
3) Wu L, Sluiter AA, Guo HF, Balesar RA, Swaab DF, Zhou JN, Verwer RW. 2007. Neural stem cells improve neuronal survival in cultured postmortem brain tissue from aged and Alzheimer patients. J Cell Mol Med. 12:1611-21.
4) Liu YJ, Zhuang J, Zhu HY, Shen YX, Tan ZL, Zhou JN. 2007. Cultured rat cortical astrocytes synthesize melatonin: absence of a diurnal rhythm. J Pineal Res. 43:232-8
5) Wu LM, Han H, Wang QN, Hou HL, Tong H, Yan XB, Zhou JN. 2007. Mifepristone repairs region-dependent alteration of synapsin I in hippocampus in rat model of depression. Neuropsychopharmacology. 32:2500-10
6) Zhu DF, Wang ZX, Zhang DR, Pan ZL, He S, Hu XP, Chen XC, Zhou JN. 2006. fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism. Brain. 129:2923-30
7) Bao AM, Hestiantoro A, Van Someren EJ, Swaab DF, Zhou JN. 2005. Colocalization of corticotropin-releasing hormone and oestrogen receptor-alpha in the paraventricular nucleus of the hypothalamus in mood disorders. Brain. 128:1301-13
8) Wu YH, Feenstra MG, Zhou JN, Liu RY, Toranõ JS, Van Kan HJ, Fischer DF, Ravid R, Swaab DF. 2003. Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages. J Clin Endocrinol Metab. 88:5898-906
9) Zhou JN, Riemersma RF, Unmehopa UA, Hoogendijk WJ, van Heerikhuize JJ, Hofman MA, Swaab DF. 2001. Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in depression. Arch Gen Psychiatry. 58:655-62
10) Zhou JN, Hofman MA, Gooren LJ, Swaab DF. 1995. A sex difference in the human brain and its relation to transsexuality. Nature. 378:68-70