Faculty Profile
  LIANG Gaolin
Department: Department of Chemistry
Mailing Address:
USTC, #96 Jinzhai Rd, Hefei, Anhui 230026, P.R.China
Postal Code:

Research Profile

LIANG Gaolin, professor and doctoral supervisor in the Department of Chemistry at the University of Science and Technology of China (USTC). Liang was admitted to the Department of Intensive Instruction at Nanjing University in 1989 (with his overall score in science subjects ranking the highest among his peers in the College Entrance Exam). Liang graduated from Nanjing University in 1993 with a bachelor’s degree in Physical Chemistry. He received his master’s degree in Chemical Technology in 2002 from Zhengzhou University and his doctoral degree in Medicinal Chemistry in 2005 from Fudan Univrsity. In the period between 1993 and 2002, he worked at the State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, engaging himself in the research of radioligand and osteoporosis medication (one of the key scientific and technological projects of the Ninth Five-Year Plan of China). From September 2005 to January 2008, Liang pursued his postdoctoral studies at the Department of Chemistry of The Hong Kong University of Science and Technology under the supervision of Professor XU Bing, dedicated himself mainly to the research of the supra-molecular hydrogel, as well as the preparation and biomedical applications of inorganic nanoparticles. From January 2008 to May 2010, Liang conducted postdoctoral studies at the School of Medicine, Stanford University, USA. Under the supervision of Professor RAO Jianghong, Liang was mainly engaged in molecular and cellular imaging studies. During his stay at Stanford, Liang independently discovered and developed a new biocompatible platform of condensation reactions which could be used for the synthesis of nanostructures in living cells. This technology platform can be widely applied to the in vitro synthesis of nanomaterials, the activity detection of key enzymes in living organisms, and the early detection and treatment of cancer. The details of this study were elaborated in the article published in Nature Chemistry.
     Liang was employed as a professor of chemistry in the Department of Chemistry of USTC in January 2010. At present, his research orientations lie in the synthesis and chemical preparation of nanomaterials used for the early detection and treatment of some important diseases. Up to now, Liang has had more than 40 papers published in journals indexed by SCI, of which 25 were in Nat. Chem., Sci. Rep., Acc. Chem. Res., Angew. Chem. Int. Ed., J. Am. Chem. Soc., Small, Anal. Chem., Chem. Commun., Soft Matter, J. Mater. Chem., and Langmuir, with the total impact factor standing at 300 and the h-factor at 17. His papers have a total of citations for more than 1500 times to date. The prizes and honors that Liang has gained include: one Certificate for Second-class National New Drug, two national patents of China, one world patent, one American patent, one third-grade prize of the Science and Technology Progress Award of Jiangsu Province, one "New Century Excellent Talents in University" award by the Ministry of Education of China, one "Anhui Provincial Science Fund for Distinguished Young Scholars" and one "100 Telents Program" by Anhui Province.
Selected Publications
1) Intracellular Self-Assembly of Cyclic D-Luciferin Nanoparticles for Persistent Bioluminescence Imaging of Fatty Acid Amide Hydrolase , ACS Nano , 2016 , DOI: 10.1021/acsnano.6b03412
2) Casp3/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis , Nano Lett. , 2016 , 16(4), 2686-2691
3) Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multi-Drug Resistance , Angew. Chem. Int. Ed. , 2015 , 54, 9700-9704
4) Oligomeric Hydrogels Self-Assembled from Reduction-Controlled Condensation , Angew. Chem. Int. Ed. , 2015 , 54(12), 3639-3642.
5) Intracellular Self-Assembly and Disassembly of 19F Nanoparticles Confer Respective “Off” and “On” 19F NMR/MRI Signals for Legumain Activity Detection in Zebrafish , ACS Nano , 2015 , 9(5),5117-5124
6) Controlled Intracellular Self-assembly and Disassembly of 19F Nanoparticles for MR Imaging of Caspase 3/7 in Zebrafish , ACS Nano , 2015 , 9, 761-768
7) Using “On/Off” 19F NMR/Magnetic Resonance Imaging Signals to Sense Tyrosine Kinase/Phosphatase Activity in Vitro and in Cell Lysates , Anal. Chem. , 2016 , 88(6), 3363-3368
8) In situ clicking methylglyoxal for hierarchical self-assembly of nanotubes in supramolecular hydrogel , Nanoscale , 2016 , 8, 766-769
9) Bipyridine hydrogel for selective and visible detection and absorption of Cd2+ , Nanoscale , 2015 , 7, 2797-2804
10) Gathering nanorings via Fe2+-bipyridine coordination , Chem. Commun. , 2015 , 51, 11045-11047
11) Enzymatic Hydrogelation-Induced Fluorescence Turn-Off for Sensing Alkaline Phosphatase in Vitro and in Living Cells , Anal. Chem. , 2015 , 87(13), 6475-6478
12) Discriminative Fluorescence Sensing of Biothiols in Vitro and in Living Cells , Anal. Chem. , 2015 , 87(6),3460-3466
13) Pyridine-Biquinoline-Metal Complexes for Sensing Pyrophosphate and Hydrogen Sulfide in Aqueous Buffer and in Cells , Anal. Chem. , 2015 , 87(5),2678-2684
14) Intracellular Disassembly of Self-Quenched Nanoparticles Turns NIR Fluorescence on for Sensing Furin Activity in Cells and in Tumors , Anal. Chem. , 2015 , 87(12),6180-6185
15) Oligomeric nanoparticles functionalized with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging , Biomaterials , 2014 , 35, 7881-7886
16) Using Magnetic Resonance Imaging to Study Enzymatic Hydrogelation , Analytical Chemistry , 2014 , 86, 5955-5961
17) Detection of Glutathione in Vitro and in Cells by the Controlled Self-assembly of Nanorings , Analytical Chemistry , 2013 , 85, 1280-1284
18) Multifunctional Fluorescence Probe for Sequential Detections of Glutathione and Caspase-3 in Vitro and in Cells , Analytical Chemistry , 2013 , 85 (13), 6203-6207
19) FITC-quencher based, caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells , Nanoscale , 2013 , 5 (19), 8963-8967
20) Enzymatic self-assembly of nanostructures for theranostics , Theranostics , 2012 , 2(2), 139-147
21) Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents , Scientific Reports , 2013 , 3, 1024
22) Intracellular self-assembly of nanoparticles for enhancing cell uptake , Chemical Communications , 2012 , 48 (78), 9738-9740
23) Controlled Self-Assembling of Gadolinium Nanoparticles as “Smart” Molecular Magnetic Resonance Imaging Contrast Agents , Angewandte Chemie International Edition , 2011 , 50: 6283-6285
24) Controlling intracellular macrocyclization for the imaging of protease activity , Angewandte Chemie International Edition , 2011 , 50: 2275-2279
25) Caspase-3 controlled assembly of nanoparticles for fluorescence turn on , Chemical Communications , 2011 , 47,10320-10322
26) A biocompatible condensation reaction for controlled assembly of nanostructures in living cells , Nature chemistry , 2010 , 2: 54-60
27) Multifunctional yolk-shell nanoparticles: A potential MRI contrast and anticancer agent , Journal of the American Chemical Society , 2008 , 130(35): 11828-11833
28) Enzymatic hydrogelation of small molecules , Accounts of Chemical Research , 2008 , 41(2): 315-326
29) Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth , Angewandte Chemie International Edition , 2007 , 46(43):8216-8219
30) Using beta-Lactamase to Trigger Supramolecular Hydrogelation , Journal of the American Chemical Society , 2007 , 129: 266-267
31) FePt@CoS2 Yolk-shell Nanocrystals as A Potent Agent to Kill HeLa Cells , Journal of the American Chemical Society , 2007 , 129: 1428-1433
32) Using a Kinase / hosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in Vivo , Journal of the American Chemical Society , 2006 , 128: 3038-3043
Recruitment information
Our lab welcome students/scholars with diverse backgrounds and expertise including synthetic and analytical chemistry, protein and nanoparticle engineering, molecular and cellular biology, medical imaging, and many more. Each individual plays crucial roles in multiple research projects and learn knowledge from each other in the interdisciplinary projects as well. We provide an excellent research and training environment for Ph.D. scientists and graduate students, medical students and residents.
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TEL: +86-551-63600279, E-mail: tianlin@ustc.edu.cn