Faculty Profile
 
  XU Xiaorong
     
Department: Precision Machinery and Instrumentation
Mailing Address:
96 Jinzhai Rd., Hefei, China
Postal Code:
230027
Phone:
86-551-63606852
Fax:
Homepage:
http://www.mbit.ustc.edu.cn/mbit/viewlist.php?aid=71&tid=3
 
       

Research Profile

RESEARCH INTERESTS:
Medical device design and innovation; tissue optics; multimodal imaging; 3D printing of tissue simulating phantom; microfabrication of drug-loaded multifunctional micro and nanobubbles; image-guided therapy.  

EDUCATION:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, MA)
Ph.D., Mechanical Engineering (1999). Advisor: Professor Emanuel Sachs.
Thesis: “Thermal management in injection molding by 3D Printing”.

STATE UNIVERSITY OF NEW YORK AT STONY BROOK (Long Island, NY)
M.S., Mechanical Engineering (1995). Advisor: Professor Peisen Huang.
Thesis: “Design of an optical probe for surface profile measurement”.

UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA (Hefei, China)
B.S., Precision Machinery and Instrumentation (1992).  

PROFESSIONAL EXPERIENCE

UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA (Hefei, China) 
Professor of Precision Machinery and Instrumentation (2012, 2014-current,Spring).

THE OHIO STATE UNIVERSITY (Columbus, OH)
Associate Professor of Biomedical Engineering (2011, 2014-current, Fall).
Assistant Professor of Biomedical Engineering (2004-2011).
Adjunct Professor of Neuroscience Graduate Program (2008-current) .
Adjunct Professor of Biophysics Program (2007-current).
Adjunct Professor of Ophthalmology (2006-current).

VIOPTIX INC.(Fremont, CA)
Director of Technology Development (2000-2004).

STANFORD UNIVERSITY (Stanford, CA) 
Postdoctoral Research Affiliate, Center for Design Research (1999-2000).

MASSACHUSETTS INSTITUTE OF TECHNOLOGY(Cambridge, MA)
Graduate Research Assistant,  3D Printing Lab (1995-1999).

BROOKHAVEN NATIONAL LAB (Upton, NY)
Student Assistant, Instrumentation Division (1994-1995).

STATE UNIVERSITY OF NEW YORK AT STONY BROOK (Long Island, NY)
Teaching Assistant, Department of Mechanical Engineering (1993-1994).	

SELECTED PUBLICATIONS
Peer-reviewed journal articles (* corresponding or senior author):
1.	S. Zhang, S. C. Gnyawali, J. Huang, W. Ren, G. Gordillo, C. Sen and R. X. Xu, "Multimodal imaging of cutaneous wound tissue," Journal of Biomedical Optics (2014, in press). (Impact factor: 3.371)
2.	Z. Zhu, T. Si, R. X. Xu*, “Microencapsulation of indocyanine green for potential applications. in image-guided drug delivery,” Lab Chip. 2014. doi:10.1039/c4lc01032a.(Impact factor: 5.8)
3.	T. Si, H. Feng, X. Luo and R. X. Xu*, "Formation of steady compound cone-jet modes and multilayered droplets in a tri-axial capillary flow focusing device," Microfluidics and Nanofluidics (2014, in press). (Impact factor: 3.218)
4.	G. Li, X. Luo, T. Si and R. X. Xu*, "Temporal instability of coflowing liquid-gas jets under an electric field," Physics of Fluids 26(054101 (2014). (Impact factor: 1.942)
5.	P. Shao, H. Ding, Z. Zhang, J. Wang and R. X. Xu*, "Author's Reply to the Reader's Comment on "Designing a Wearable Navigation System for Image-Guided Cancer Resection Surgery", Ann Biomed Eng (2014). (Impact factor: 2.575)
6.	P. Shao, H. Ding, J. Wang, P. Liu, Q. Ling, J. Chen, J. Xu, S. Zhang and R. X. Xu*, "Designing a wearable navigation system for image-guided cancer resection surgery," Ann Biomed Eng 42(11), 2228-2237 (2014). (Impact factor: 2.575)
7.	Cao, Y., R. X. Xu, and Z. Liu, “A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry,” J Chromatogr B Analyt Technol Biomed Life Sci, 2014. 949-950: p. 70-8.
8.	Pu, C., S. Chang, J. Sun, S. Zhu, H. Liu, Y. Zhu, Z. Wang, and R. X. Xu. "Ultrasound-Mediated Destruction of Lhrha-Targeted and Paclitaxel-Loaded Lipid Microbubbles for the Treatment of Intraperitoneal Ovarian Cancer Xenografts," Mol Pharm 11, no. 1 (Jan 6 2014): 49-58. (Impact factor: 4.388)
9.	Liu, H., S. Chang, J. Sun, S. Zhu, C. Pu, Y. Zhu, Z. Wang, and R. X. Xu. "Ultrasound-Mediated Destruction of Lhrha-Targeted and Paclitaxel-Loaded Lipid Microbubbles Induces Proliferation Inhibition and Apoptosis in Ovarian Cancer Cells." Mol Pharm 11, no. 1 (Jan 6 2014): 40-8. (Impact factor: 4.388).
10.	Si, T., L. Zhang, G. Li, C. J. Roberts, X. Yin, and R. Xu. "Experimental Design and Instability Analysis of Coaxial Electrospray Process for Microencapsulation of Drugs and Imaging Agents." J Biomed Opt 18, no. 7 (Jul 2013): 075003. (Impact factor: 3.371)
11.	L. Zhang, J. Huang, T. Si, and R. X. Xu*, "Co-axial electrospray of microparticles and nanoparticles for biomedical applications," Expert Review of Medical Devices, 9 (6): 595-612 (2012). (Impact factor: 2.052)
12.	S. Chang, J. Guo, J. Sun, S. Zhu, Y. Yan, Y. Zhu, M. Li, Z. Wang, and R. X. Xu*, "Targeted microbubbles for ultrasound mediated gene transfection and apoptosis induction in ovarian cancer cells," Ultrason Sonochem, vol. 20, pp. 171-9 (2013). (Impact factor: 3.567)
13.	K. Mitra, J. Melvin, S. Chang, K. Park, A. Yilmaz, S. Melvin, and R. X. Xu*, "Indocyanine Green loaded microballoons for biliary imaging in cholecystectomy," Journal of Biomedical Optics, 17(11): 116025  (2012). (Impact factor: 3.371)
14.	R. X. Xu*, D. W. Allen, J. Huang, S. Gnyawali, J. Melvin, H. Elgharably, G. Gordillo, K. Huang, V. Bergdall, M. Litorja, J. P. Rice, J. Hwang, and C. K. Sen, "Developing digital tissue phantoms for hyperspectral imaging of ischemic wounds," Biomed Opt Express, vol. 3, pp. 1433-45 (2012).
15.	Ronald Xu*, "Multifunctional microbubbles and nanobubbles for photoacoustic imaging," Contrast Media Mol Imaging 6:401-411 (2011). (Impact factor: 3.392, invited paper)
16.	Ronald Xu*, Jeff Xu, Tao Zuo, Rulong Shen, Tim Huang, and Michael Tweedle. Drug-loaded biodegradable microspheres for image-guided combinatory epigenetic therapy. Journal of Biomedical Optics. Vol. 16, no. 2: 020507 (2011). (Impact factor: 3.371)
17.	Chulhong Kim, Ruogu Qin, Jeff Xu, Lihong Wang *, and Ronald Xu*.  Ultrasound and photoacoustic dual-modal imaging of thick biological tissue with microbubble enhancement.  Journal of Biomedical Optics. Vol. 15, no. 1: 010510 (2010). (Impact factor: 3.371)
18.	Hamid El-Dahdah, Bei Wang, Guanglong He, Ronald X. Xu*. An Automatic Occlusion Device for Remote Control of Tumor Tissue Ischemia.  Technology in Cancer Research and Treatment. Vol. 1, no. 9: 71-76 (2010). (Impact factor: 2.627)
19.	Jeff Xu, Jiwei Huang, Ruogu Qin, Stephen Povoski, Edward Martin, Ronald Xu*. Synthesizing and binding dual-mode poly (lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging.  Biomaterials. Vol. 7, no. 31: 1716-1722 (2010). (Impact factor: 7.325)
20.	Jiwei Huang, Jeff S. Xu, Ronald X. Xu*. Heat-sensitive microbubbles for intraoperative assessment of cancerablation margins. Biomaterials. Vol. 6, no. 31: 1278-1286 (2010). (Impact factor: 7.325)
21.	Leilei Zhang, Jeff S. Xu, Virginia M. Sanders, Alan D. Letson, Cynthia J. Roberts, and Ronald X. Xu*, Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy, Journal of Biomedical Optics. Vol. 15, no. 3, p 030515. (2010). (Impact factor: 3.371)
22.	Peng Zou, Stephen P. Povoski,*, Nathan C. Hall, Michelle M. Carlton, George H. Hinkle, Ronald X. Xu, Cathy M. Mojzisik, Morgan A. Johnson, Michael V. Knopp, Edward W. Martin, and Duxin Sun. 2010. 124I-HuCC49deltaCH2 for TAG-72 antigen-directed positron emission tomography (PET) imaging of LS174T colon adenocarcinoma tumor implants in xenograft mice: Preliminary results.  World Journal of Surgical Oncology. Vol 8, p 65 (2010). 
23.	Ronald X. Xu, Kun Huang, Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Urmila S. Gnyawali, Gayle Gordillo, Surya C. Gnyawali, and Chandan K. Sen*. Dual-mode imaging of cutaneous tissue oxygenation and tissue vascular thermal reactivity.  Journal of Visualized Experiments. doi: 10.3791/2095 (2010). 
24.	Ronald Xu*, Stephen Povoski, Edward Martin. Targeted delivery of microbubbles and nanobubbles for image-guided thermal ablation therapy of tumors.  Expert Rev Med Devices. 7(3): p303-6. (2010). (Impact factor: 2.052)
25.	Peng Zou, Songbo Xu, Stephen P. Povoski, Anna Wang, Morgan A. Johnson, Edward W. Martin, Jr., Vish Subramaniam, Ronald Xu*, and Duxin Sun*. Near-Infrared Fluo-rescence Labeled Anti-TAG-72 Monoclonal Antibodies for Tumor Imaging in Colorectal Cancer Xenograft Mice.  Molecular Pharmaceutics. Vol. 6, no. 2: 428-440. (2009). (Impact factor: 4.388)
26.	Ronald Xu*, Jiwei Huang, Jeff Xu, Duxin Sun, George Hinkle, Edward Martin and S. Povoski. Fabrication of indocyanine green encapsulated biodegradable micro-bubbles for structural and functional imaging of cancer.  Journal of Biomedical Optics. Vol. 14, no. 3: 034020(2009). (Impact factor: 3.371) 
27.	Stephen P. Povoski*, Rafael E. Jimenez, Wenle P. Wang, Ronald X. Xu. Standardized and reproducible methodology for the comprehensive and systematic assessment of surgical resection margins during breast-conserving surgery for invasive breast cancer.  BMC Cancer. Vol. 9, no. 1: 254. (2009). (Impact factor: 3.159)
 
     
Recruitment information