Faculty Profile
  Na Zhang
Department: High Magnetic Field Laboratory, Chinese Academy of Sciences in Hefei
Mailing Address:
High Magnetic Field Laboratory, Chinese Academy of Sciences, Shu Shan Hu Lu 350, Hefei, Anhui 230031 P.R.China
Postal Code:

Research Profile

Na Zhang received his B.S. degree in chemistry from Chemistry Department of Nankai University in 1989, his M.S. degree in organic synthesis from Chemistry Department of Brigham Young University in 1999, and his Ph.D. degree in biochemistry & structural biology from Cornell University Graduate School of Medical Sciences in 2005. Subsequently he pursued a two-year postdoc as a research fellow at BCMP Department, Harvard Medical School and then a four-year HHMI postdoc as a research associate at Massachusetts General Hospital/Harvard Medical School. Following his postdoctoral work, in February 2012, Na joined High Magnetic Field Laboratory, Chinese Academy of Sciences in Hefei, as an associate professor and was promoted to a full professor a year later.
During his Ph.D. study and postdoctoral work, Na has been applying NMR to identify the interactions between carcinogenic small molecules binding with DNA/RNA; to solve 3D structures of DNA-drug complex and the higher order DNA architectures of G-quadruplex formed by guanine-rich sequences, including the fragment of human telomeric DNA repeats; and to characterize the self-chemical replication of nucleic acid systems which function as a key component of a primitive cell in origin of life.

Currently in Na Zhang's group, nucleic acid structural biology is the main scheme. In particular, the solution NMR will be used as a primary tool to understand the structure, dynamics and function of biologically significant RNA and DNA, as well as their corresponding complexes interacted with protein or small molecule ligand.
Selected Publications
1) (3+1) assembly of three human telomeric DNA repeats into an asymmetrical dimeric G-quadruplex. , J Am Chem Soc. , 2005 , (2005) 127, p17277-17285.
2) Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template , J Am Chem Soc. , 2012 , (2012) 134, p3691-3694.
3) Synthesis of N3′-P5′-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension , J Am Chem Soc. , 2013 , (2013), 135, p924-932.
4) Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity , Proc Natl Acad Sci USA , 2011 , (2011) 108, p13492-13497.
5) Thermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions. , Biochemistry. , 2013 , (2013) 52, p1354-1363.
6)  NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms. , Biochemistry , 2009 , (2009) 48, p7098-7109.
7)  Solution structure of a designed spirocyclic helical ligand binding at a two-base bulge site in DNA. , Biochemistry , 2007 , (2007) 46, p4793-4803.
8) Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR, , Chem. Commun. , 2006 , (2006) 42, p4431-4433.
Recruitment information
Postdoc/PhD student/MS student positions are available. Postdocs, Ph.D and MS graduate students with strong background in biology, chemistry are very welcome, especially with hand-on experiences in macromolecular NMR, structural biology and/or RNA/DNA biology are highly preferred. If interested, please send your CV to nazhang@hmfl.cas.cn
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TEL: +86-551-63600279, E-mail: tianlin@ustc.edu.cn