Faculty Profile
  TIAN Zhigang
Department: School of Life Science
Mailing Address:
School of Life Science, University of Science and Technology of China, 443 Huangshan Rd, Hefei, Anhui, PR China
Postal Code:

Research Profile

    Tian Zhigang is selected into CAS Hundred Talents Program, winner of National Natural Science Founds for Distinguished Young Scholars, and academic leader of Innovative Research Group of National Natural Science of Foundation of China. He used to serve as director of Institute of Basic Medicine, Shandong Academy of Medical Sciences, director of Tumor Biotherapy Center of Shandong Province, and director of Shandong Key Laboratory for Tumor Immunity and Genetic Engineering. Since 1993, he has been to National Cancer Institute (NCI), U.S. National Institutes of Health (NIH) five times to collaborate in researches. In 2001 he won the Research Project Award of Union for International Cancer Control (UICC). Prof. Tian won the title of“Young Experts with Outstanding Contributions”. In September 2001, with the support of CAS Hundred Talents Program, Prof. Tian entered University of Science and Technology of China (USTC), and established a scientific research institution-Institute of Immunology. Now he is dean of School of Life Sciences, USTC, and director of Institute of Immunology and director of Anhui Key Laboratory for Molecular Medicine. In the meantime Prof. Tian has assumed the following posts: Vice President of Chinese Society for Immunology; President of the Branch Society for Tumor Immunology and Biotherapy, Chinese Society for Immunology and Deputy Director of Professional Committee for Biological Therapy, Executive Chief Editor of Cellular & Molecular Immunology, an English journal of Chinese Society for Immunology.
Prof. Tian is mainly engaged in applied basic research for natural immunity, disease mechanism and related biological therapy. In the beginning of 1990s, he took the lead in researching NK cells at mainland China, carried out immunologic research for liver in the end of 1990s, systematically studied immune mechanism of liver damage and NK/NKT cells, established a series of NK cell-mediated hepatitis model and solved some technical problems of Liver NK cells. He studied human NK cell subsets with the distinguished function, found innate immune recognition as one of molecular mechanisms of liver immune injury, explained clearly pathologic role of NK cell receptors in liver damage and discovered valuable molecular targets. He discovered regulatory NK cell subsets with the value of immunologic therapy. 
Prof. Tian has published totally 115 papers, and since 2002 he has published 82 SCI papers, such as 2 papers in PNAS, 6 papers in Hepatology, 3 papers in J Heptol, 6 papers in J Immunol. He gave speeches on or presided over international conferences or international organizations over 20 times, and in 2008 he made a comprehensive report on “Innate Immune-mediated Liver Injury” at the Annual Conference of American Associate of Immunologists (AAI).
Selected Publications
1) NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice , Proceedings of National Academy of Science USA , 2007 , 104(18):7512-5.
2) TLR-3 ligand attenuates LPS-induced liver injury by down-regulation of TLR-4 expression on macrophages. , Proceedings of National Academy of Sciences USA , 2005 , 102 (47): 17077-17082.
3) NKG2D-retinoic acid early inducible-1 recognitionbetween natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.. , Hepatology , 2009 , 2009
4) Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. , Hepatology , 2008 , 47:648-58
5) Liver: An organ with predominant innate immunity.Review , Hepatology. , 2008 , 47(2):729-36.
6) Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice. , Hepatology , 2007 , 45(6):1400-12
7) Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. , Hepatology. , 2007 , 46(3):706-15
8) Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. , Hepatology , 2006 , 43(6):1211-9.
9) CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. , J Immunol. , 2008 , 181(10):7221- 9
10) Recognition of double-stranded RNA by Toll-like receptor 3 induces severe small intestinal injury in mice , Journal of Immunology , 2007 , 178(7):4548-56
11) NK3-like NK cells are involved in protective effect of poly I:C on type I diabetes in nonobese diabetic mice , Journal of Immunology , 2007 , 178 (4): 2141-2147
12) Toll-like receptor 9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. , J Immunol , 2009 , 2009
13) Human NK cells positively regulate gammadelta T cells in response to Mycobacterium tuberculosis , Journal of Immunology , 2006 , 176(4):2610-6.
14) Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. , Journal of Hepatology , 2006 , 44(3):446-54.
15) Liver-specific HBsAg transgenic mice are over-sensitive to Poly (I:C)-induced liver injury in NK cell- and IFN--dependent manners. , Journal of Hepatology , 2007 , 47(2):183-90.
16) Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. 23.Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. , Hepatology , 2011 , 53(1):219-29.
17) Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner , Hepatology , 2011 , 54(4):1179-89.
18) LFA-1 and CD2 synergize for the ERK1/2 activation in the NK cell immunological synapse. , J Biol Chem , 2009 , 2009
19) 15.Establishment, Characterization and Successful Adaptive Therapy against Human Tumors of NKG Cell, a New Human NK Cell Line , Cell Transplant. , 2011 , 2011 Jun 7.
20)  Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection , Journal of virology , 2012 , 卷: 86 期: 4 页: 2251-8
21) IFN-γ induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice , J Autoimmun , 2012 , 38(1):20-8.
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