Faculty Profile
 
  Zhiyou Fang
     
Department: Center of Medical Physics and Technology, Hefei Institutes of Physical Sciences, CAS
Mailing Address:
350 Shushanhu Road, Hefei,Anhui, P.R.China
Postal Code:
230031
Phone:
18955116472
Fax:
Homepage:
 
       

Research Profile

	  
      under construction ......
      
 
     
Selected Publications
1) Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway , J Exp Clin Cancer Res , 2018 , 2018 Jun 28
2) Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/ CCL20 in glioma , Oncotarget , 2017 , 8(55):93580-93592
3) EZH2 palmitoylation mediated by ZDHHC5 in p53 mutant glioma drives malignant development and progression. Cancer Res , Cancer Res. , 2017 , 77(18):4998-5010
4) Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis , J Pineal Res. , 2016 , 61(2):208~217
5) Supervillin-mediated suppression of p53 protein enhances cell survival , Journal of Biological Chemistry , 2013 , 288 (11):7918~7929
6) A novel splice variant of supervillin, SV5, promotes carcinoma cell proliferation and cell migration , Biochem Biophys Res Commun. , 2017 , 482(1):43-49
7) Supervillin couples myosin-dependent contractility to podosomes and enables their turnover , Journal of Cell Science , 2012 , 125(Pt 9): 2300~2314
8) The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility , Traffic , 2010 , 11(6) : 782~799
9) Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4 , Molecular & Cellular Proteomics , 2006 , 5(8):1437~1449
10) Novel interactors and a role for supervillin in early cytokinesis , Cytoskeleton (Hoboken) , 2010 , 67(6): 346~364
11) Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency , Molecular Biology of the Cell , 2009 , 20(3):948~962
12) Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress , Circulation , 2012 , 125(22):2762~2771
13) Preparation and Affinity-Purification of Supervillin Isoform 4 (SV4) Specific Polyclonal Antibodies , Protein J. , 2016 , 35(2):107~114
 
Recruitment information
All candidates interested in cancer biology are welcome.
Research interest:
1. Mechanism of Tumor cell invasion and migration;
2. Regulation of Cell proliferation and Genome instability;
3. Relationship of Tumorigenesis and Palmitoylation mediated by ZDHHC family.
Contact:
Tel:+86-551-62727067
Email: z.fang@cmpt.ac.cn
Address: Center of Medical Physics and Technology, Hefei Physical Science Institutes, CAS, Anhui, China. 
       
       
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TEL: +86-551-63600279, E-mail: tianlin@ustc.edu.cn