Faculty Profile
 
  Yao Xuebiao
     
Department: School of Life Science
Mailing Address:
School of Life Science,University of Science and Technology of China, 443 Huangshan Rd, Hefei, Anhui, PR China
Postal Code:
230027
Phone:
86-551-63606304
Fax:
86-551-63607141
Homepage:
http://biox.ustc.edu.cn/szdw/szcjxz/201112/t20111203_125727.html
 
       

Research Profile

    Yao Xuebiao, professor and Ph.D. supervisor, is the first distinguished professors of Changjiang Scholars Program.
He began to study at University of California, Berkeley in 1991 and obtained his Ph.d. in Celluar and Molecular Biology in 1995. From 1995 to 1997 he served as postdoctoral fellow at University of California, San Diego. In 1997 he was appointed as assistant professor of University of Wisconsin. In 1997 he won the Industrial Scholar Award of American Digestive Health Foundation. In 1999 he was elected as distinguished professors of Changjiang Scholars Program and began to serve as a specially invited professor at School of Life Science, USTC. In the same time, he was supported by National Natural Science Funds for Distinguished Young Scholar. In 2000 he took charge of Knowledge Innovation Projects of the Chinese Academy of Sciences. In 2001 he served as leader of research group for “863 Program” of Ministry of Science and Technology. In 2002 he served as chief scientist of “973 Program” of Ministry of Science and Technology- Study on Interaction Network of Control of Cell Proliferation and Transferring Important Protein of Tumour Cell. In 2003 he won the AACR-NCI Oncogenomics Faculty Research Award.
 
     
Selected Publications
1) Phosphorylation of SKAP by GSK3β ensures chromosome segregation by a temporal inhibition of Kif2b activity , Sci Rep , 2016 , 6:38791
2) Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking , Mol Biol. Cell , 2014 , 25,4166-74.
3) CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3 , cancer cell , 120412 , 19(4): 541-555
4) Phosphorylation of PP1 regulator Sds22 by PLK1 ensures accurate chromosome segregation , J Biol Chem , 2016 , 291(40):21123-21136
5) Spatial control of proton pump H,K-ATPase docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 interaction , J Biol. Chem , 2014 , 289, 33333-42
6) Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. , Cancer Res. , 110301 , 71:1721-1729
7) The Microtubule Plus End Tracking Protein TIP150 Interacts with Cortactin to Steer Directional Cell Migration , J Biol Chem , 2016 , 291(39):20692-706
8) Mitotic regulator Mis18β interacts with and specifies the centromeric assembly of molecular chaperone HJURP , J Biol. Chem , 2014 , 289, 8326-8336
9) Aurora b kinase activation requires survivin priming phosphorylation by plk1. , J Mol Cell Biol. , 101215 , 3:260-267
10) Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation , Nat Chem Biol , 2016 , 12(4):226-32
11) HP1α interacts with borealin and specifies the centromere localization of chromosomal passenger complex , J Biol Chem. , 2014 , 289, 20638-20649.
12) A general user interface for prediction servers of proteins' post-translational modifi cation sites , Nature Protocol , 2006 , 1, 1318-1321.
13) IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver , J Mol Cell Biol , 2016 , 8(2):144-56
14) Spatiotemporal dynamics of chromatin protein HP1α is essential for accurate chromosome segregation during cell division. , J Biol Chem , 2014 , 289, 26249-62.
15) Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. , Oncogene , 2008 , 27: 931-941.
16) Cell Polarity Kinase MST4 Cooperates with cAMP-dependent Kinase to Orchestrate Histamine-stimulated Acid Secretion in Gastric Parietal Cells , J Biol Chem , 2015 , 290(47):28272-85
17) Phosphorylation of BAR domain of ACAP4 regulates membrane tubulation. , Proc Natl Acad Sci U S A , 2013 , 110, 11023-8.
18) Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression , J Biol Chem , 200709 , 282(37):27414-23
19) Mitotic Protein CSPP1 Interacts with CENP-H Protein to Coordinate Accurate Chromosome Oscillation in Mitosis , J Biol Chem , 2015 , 290(45):27053-66
20) Acetylation-dependent regulation of kinetochore microtubule signaling by PCAF acetyltransferase , Proc Natl Acad Sci U S A , 2012 , 109, 16564-9.
21) Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration , J Biol Chem , 2015 , 290(39):23766-80
22) The structure of structure of the FANCM-MHF complex reveals physical features for functional assembly. , Nature Commun , 2012 , 3, 782-791.
23) Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment , Proc Natl Acad Sci U S A , 2015 , 112(33):E4546-55
24) SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis. , J Mol Cell Biol. , 2012 , 4, 331-340.
25) Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation , Sci Rep , 2015 , 5:12204
26) CCL18 from tumor associated macrophages promotes breast cancer metastasis via CCR18. , Cancer Cell. , 2011 , 19, 541-55
27) PhosSNP for systematic analysis of genetic polymorphisms that influence protein phosphorylation , Mol Cell Proteomics. , 2010 , 9, 623-634.
28) Probing cenp-e function in chromosome dynamics using small molecule inhibitor syntelin. , Cell Res. , 101202 , 20:1386-1389
29) TIP150 interacts with and targets MCAK to the plus-end of microtubules , EMBO Rep , 2009 , 10, 857-65.
30) Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death , Cell Res. , 2009 , 19, 1350-1362.
31) Phosphorylation of Sgo1 by NEK2A is essential for chromosome segregation. , Cell Res. , 2007 , 17
32) Proteomic identification and functional characterization of a novel ARF6 GTPa se-activating protein ACAP4 , Mol.& Cell Proteomics , 2006 , 5, 1437-1449
33) Cell biology of acid secretion by parietal cells. , Ann.Rev.Physiol , 2003 , 2003 65:103-31
34) CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic check , Nature Cell Biology . , 200008 , 2:484-491,August 2000
 
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