Faculty Profile
 
  WANG Jun
     
Department: School of Life Sciences
Mailing Address:
443 Huangshan Road, Building of School of Life Sciences, University of Science and Technology of China
Postal Code:
230026
Phone:
+86-551-63600335
Fax:
86-551-63600402
Homepage:
http://nanomedicine.ustc.edu.cn/syscy_1/wjjs/201405/t20140516_196194.html
 
       

Research Profile

	  
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Selected Publications
1) Enhancement of Lipopolysaccharide-Induced Nitric Oxide and Interleukin-6 Production by PEGylated Gold Nanoparticles in RAW264.7 Cells , Nanoscale , 2012 , 4, 7135-7142
2) Therapeutic Delivery of siRNA Silencing HIF-1 Alpha with Micellar Nanoparticles Inhibits Hypoxic Tumor Growth , Molecular Pharmaceutics , 2012 , 9, 2863-2874
3) In Vitro and In Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles , Advanced Materials , 2012 , 24, 5586-5592
4) Bacteria-Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery , Advanced Materials , 2012 , 24, 6175-6180
5) Surface Charge Switchable Nanoparticles based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor , Advanced Materials , 2012 , 24, 5476-5480
6) Anti-Her2 Single-Chain Antibody Mediated DNMTs-siRNA Delivery for Targeted Breast Cancer Therapy , Journal of Controlled Release , 2012 , 161, 875-883
7) Combating the Drug Resistance of Cisplatin Using a Platinum Prodrug Based Delivery System , Angewandte Chemie-International Edition , 2012 , 51, 6742-6747
8) Single-Step Assembly of Cationic Lipid-Polymer Hybrid Nanoparticles for Systemic Delivery of siRNA , ACS Nano , 2012 , 6, 4955-4965
9) Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis , Science Translational Medicine , 2012 , 4, 130ra48
10) The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency , Macromolecular Bioscience , 2012 , 12, 666-674
11) Biocompatible and Functionalizable Polyphosphate Nanogels with A Branched Structure , Journal of Materials Chemistry , 2012 , 22, 9322-932
12) Lipase-Sensitive Polymeric Triple-Layered Nanogel for “On-Demand” Drug Delivery , Journal of the American Chemical Society , 2012 , 134, 4355-4362
13) Sheddable Ternary Nanoparticles for Tumor Acidity-Targeted siRNA Delivery , ACS Nano , 2012 , 6, 771-781
14) Micelle-to-Vesicle Morphological Transition via Light-Induced Rapid Hydrophilic Arm Detachment from a Star Polymer , Chemical Communications , 2012 , 48, 1257-1259
15) Two Consecutive Click Reactions as a General Route to Functional Cyclic Polyesters , Chemical Communications , 2012 , 48, 570-572
16) Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery , Journal of the American Chemical Society , 2011 , 133, 17560-17563
17) Pivotal Role of Reduced Let-7g Expression in Breast Cancer Invasion and Metastasis , Cancer Research , 2011 , 71, 6463-6474
18) Redox-Responsive Nanoparticles from the Single Disulfide Bond-Bridged Block Copolymer as Drug Carriers for Overcoming Multi-Drug Resistance in Cancer Cells , Bioconjugate Chemistry , 2011 , 22, 1939-1945
19) Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy , Journal of Controlled Release , 2011 , 156, 203-211
20) Nanofiber-Mediated Controlled Release of siRNA Complexes for Long Term Gene-Silencing Applications , Biomaterials , 2011 , 32, 5915-5923
21) Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells , ACS Nano , 2011 , 5, 3679-3692
22) Multiple Functional Hyperbranched Poly(amido amine) Nanoparticles: Synthesis and Application in Cell Imaging , Biomacromolecules , 2011 , 12, 1523-1531
23) A Biodegradable Amphiphilic and Cationic Triblock Copolymer for the Delivery of siRNA Targeting the Acid Ceramidase Gene for Cancer Therapy , Biomaterials , 2011 , 32, 3124-3133
24) Phosphoester modified poly(ethylenimine) as efficient and low cytotoxic genevectors , Science China Chemistry , 2011 , 54, 351-358
25) Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression , ACS Nano , 2011 , 5, 1483-1494
26) Targeted delivery of antisense inhibitor of miRNA for antiangiogenesis therapy using cRGD-functionalized nanoparticles , Molecular Pharmaceutics , 2011 , 8, 250-259
27) Syntheses and Characterization of Block Copolymers of Poly(aliphatic ester) with Clickable Polyphosphoester , J Polymer Science Part A: Polymer Chemisty , 2011 , 49, 487-494
28) Temperature-Induced Morphological Changes of ABC 3-Miktoarm Star Terpolymer Assemblies in Aqueous Solution , Colloid and Surface B: Biointerfaces , 2011 , 85, 81-85
29) Gold Nanorods for Platinum Based Prodrug Delivery , Chemical Communications , 2010 , 46, 8424-8426
30) Poly(ε-caprolactone)-Block-poly(ethyl Ethylene Phosphate) Micelles for Brain Targeting Drug Delivery: In Vitro and In Vivo Valuation , Pharmaceutical Research , 2010 , 27, 2657-2669
31) Electrosprayed core-shell microspheres for protein delivery , Chemical Communications , 2010 , 46, 4743-4
32) Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery , Chem. Commun , 2010 , 46, 3520–3522
33) Brush-shaped polycation with poly(ethylenimine)-b-poly(ethylene glycol) side chains as highly efficient gene delivery vector , International Journal of Pharmaceutics , 2010 , 392, 118–126
34) A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery , Angew. Chem. Int. Ed , 2010 , 49, 3621 –3626
35) Core–Shell–Corona Micelle Stabilized by Reversible Cross-Linkage for Intracellular Drug Delivery , Macromol. Rapid Commun , 2010 , 31, 1201–1206
36) Localized SDF-1alpha Gene Release Mediated by Collagen Substrate Induces CD117+ Stem Cell Homing , Journal of Cellular and Molecular Medicine , 2010 , 14, 392-402
37) One-Pot Syntheses of Amphiphilic Centipede-like Brush Copolymers via Combination of Ring-Opening Polymerization and “Click” Chemistry , Macromolecules , 2010 , 43, 1739-1746
38) Cytotoxicity and Cellular Uptake of Iron Nanowires , Biomaterials , 2010 , 7, 1509-1517
39) Gold Nanoparticles Capped with Polyethyleneimine for Enhanced siRNA Delivery , small , 2010 , 6, 239–246
40) Recent Progress in Polyphosphoesters:From Controlled Synthesis to Biomedical Applications , Macromolecular Bioscience , 2009 , 9, 1154–1164
41) Template-free synthesis of biodegradable nanogels with tunable sizes as potential carriers for drug delivery , Journal of Materials Chemistry , 2009 , 19, 7856–7863
42) Biodegradable vesicular nanocarriers based on poly(3-caprolactone)-block-poly(ethyl ethylene phosphate) for drug delivery , Polymer , 2009 , 50, 5048–5054
43) Localized and Sustained SDF-1 Gene Release Mediated by Fibronectin Films: A Potential Method for Recruiting Stem Cells , International Journal of Artificial Organs , 2009 , 32, 141-149
44) Synthesis and Thermoresponsive Behaviors of Biodegradable Pluronic Analogs , Journal of Polymer Science: Part A: Polymer Chemis , 2009 , 47, 6168-6179
45) Gold Nanoparticles Stabilized by Thermosensitive Diblock Copolymers of Poly(ethylene glycol) and Polyphosphoester , Langmuir , 2009 , 25(17), 10298–10304
46) Evaluation of Polymeric Micelles from Brush Polymer with Poly(epsilon-caprolactone)-b-Poly(ethylene glycol) Side Chains as Drug Carrier , Biomacromolecules , 2009 , 10, 2169-2174
47) Syntheses of Amphiphilic Biodegradable Copolymers of Poly(ethyl ethylene phosphate) and Poly(3-hydroxybutyrate) for Drug Delivery , Science in China Series B: Chemistry , 2009 , 52,961-968
48) Block Copolymer of Polyphosphoester and Poly(L-Lactic Acid) Modified Surface for Enhancing Osteoblast Adhesion, Proliferation, and Function , Biomacromolecules , 2009 , 10, 2213–2220
49) Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery , Bioconjugate Chemistry , 2009 , 20, 1095-1099
50) Tunable Thermosensitivity of Biodegradable Polymer Micelles of Poly(ε-caprolactone) and Polyphosphoester Block Copolymers , MACROMOLECULES , 2009 , 42, 3026-3032
51) Synthesis of PEG-Armed and Polyphosphoester Core-Cross-Linked Nanogel by One-Step Ring-Opening Polymerization , MACROMOLECULES , 2009 , 42, 893-896
52) Thermoresponsive Block Copolymers of Poly(ethylene glycol) and Polyphosphoester: Thermo-Induced Self-Assembly, Biocompatibility and Hydrolytic Degradation , BIOMCROMOLECULES , 2009 , 10, 66-73
53) Synthesis of Amphiphilic ABC 3-Miktoarm Star Terpolymer by Combination of Ring Opening Polymerization and “Click” Chemistry , MACROMOLECULES , 2008 , 41, 8620-8625
54) Synthesis and Characterization of Star-Shaped Block Copolymer of Poly(epsilon-caprolactone) and Poly(ethyl ethylene phosphate) as Drug Carrier , Polymer , 2008 , 49, 4784-4790
55) Functionalized Diblock Copolymer of Poly(ε-caprolactone) and Polyphosphoester Bearing Hydroxyl Pendent Groups: Synthesis, Characterization and Self-Assembly , MACROMOLECULES , 2008 , 41, 6935-6941
56) Synthesis and Characterization of Amphiphilic Block Copolymer of Polyphosphoester and Poly(L-lactic acid) , Journal of Polymer Science Part A: Polymer Chemist , 2008 , 46, 6425-6434
57) Self-Assembled Biodegradable Micellar Nanoparticles of Amphiphilic and Cationic Block Copolymer for siRNA Delivery , Biomaterials , 2008 , 29, 4348-4355
58) Functionalized Micelles from Block Copolymer of Polyphosphoester and Poly(epsilon-caprolactone) for Receptor-Mediated Drug Delivery , Journal of Controlled Release , 2008 , 128, 32-40
59) Biodegradable Polycation and Plasmid DNA Multilayer Film for Prolonged Gene Delivery to Mouse Osteoblasts , Biomaterials , 2008 , 29,733-741
60) Self-assembled Micelles of Biodegradable Triblock Copolymers Based on Poly(ethyl ethylene phosphate) and Poly(epsilon-caprolactone) as Drug Carriers , Biomacromolecules , 2008 , 9, 388-395
61) Synthesis and Characterization of Photocrosslinked Hydrogel Based on Biodegradable Polyphosphoester and Poly(ethylene glycol) Copolymer , Biomacromolecules , 2007 , 8, 3375-3381
62) Block Copolymerization of ε-Caprolactone and 2-Methoxyethyl Ethylene Phosphate Initiated by Aluminum Isopropoxide: Synthesis, Characterization, and Kinetics , Macromolecules , 2006 , 39, 8992-8998
63) Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate , Macromolecules , 2006 , 39, 6825-6831
64) Synthesis and Micellization of Amphiphilic Brush-Coil Block Copolymer Based on Poly(ε-caprolactone) and PEGylated Polyphosphoester , Biomacromolecules , 2006 , 7, 1898-1903
65) Synthesis and Characterization of Block Copolymer of Polyphosphoester and Poly(epsilon-caprolactone) , Macromolecules , 2006 , 39, 473-475
66) Biodegradable and photocrosslinkable polyphosphoester hydrogel , Biomaterials , 2006 , 27, 1027-1034
67) Regulating the surface poly(ethylene glycol) density of polymeric nanoparticles and evaluating its role in drug delivery in vivo , Biomaterials , 2015-8 , 2015年
 
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TEL: +86-551-63600279, E-mail: tianlin@ustc.edu.cn