Faculty Profile
 
  XIAO W. OR Weihua X.
     
Department: School of Life Science
Mailing Address:
School of Life Science,University of Science and Technology of China, 443 Huangshan Rd, Hefei, Anhui, PR China
Postal Code:
230027
Phone:
+86-551-3606294
Fax:
86-551-3600535
Homepage:
http://lstt.ustc.edu.cn/a/gb2312/chengyuanjieshao/2011/0612/1.html
 
       

Research Profile

	  
      under construction ......
      
 
     
Selected Publications
1) Reduced expression of ΔΝp63α in cervical squamous cell carcinoma. , Clin Invest Med. , 2011 , 34(3):E184.
2) In vivo activity of novel anti-ErbB2 antibody chA21 alone and with Paclitaxel or Trastuzumab in breast and ovarian cancer xenograft models , Cancer Immunol Immunother. , 2011 , 60(3):339-48.
3) Gene associated with retinoid-interferon-induced mortality-19 suppresses growth of lung adenocarcinoma tumor in vitro and in vivo. , Lung Cancer. , 2011 , 72(3):287-93
4) Identification and characterization of GRIM-1, a cell-death-associated gene product. , J Cell Sci. , 2010 , 123(Pt 16):2781-91
5) Transcription factor E2F1 suppresses dendritic cell maturation. , J Immunol. , 2010 , 184(11):6084-91
6) Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. , J Biol Chem. , 2009 , 284(50):34600-6.
7) Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers. , J Interferon Cytokine Res. , 2009 , 29(10):695-703
8) Expression and clinical significance of GRIM-19 in non-small cell lung cancer , Ai Zheng. , 2009 , 28(4):431-5
9) E2F1 induces tumor cell survival via NF-κB-dependent induction of EGR1 transcription in prostate cancer , Cancer Research , 2009 , 2009.69(6);2324-2331
10) 外周血单核细胞来源的树突状细胞成熟过程中Toll样受体的既时表达变化 , 《中华微生物和免疫学杂志》 , 2008 , 2008(7)
11) 转录因子PAX5对多发性骨髓瘤细胞IM9的抗凋亡及促增生作用 , 中国免疫学杂志 , 2008 , 2008(24)
12) 人干扰素α2b和IgG Fc片段融合蛋白显著延长体内半 衰期 , 生物工程学报 , 2008 , 2008年第一期
13) The interferon signaling network and transcription factor C/EBP-beta. , Cell Mol Immunol. , 2007 , 4(6):407-18
14) mRNA secondary structure at start AUG codon is a key limiting factor for human protein expression in Escherichia coli. , Biochem Biophys Res Commun. , 2006 , 349(1):69-78
15) Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis. , Cancer Res. , 2005 , 65(14):6255-63
16) Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. , J Biol Chem. , 2005 , 280(6):4182-7
17) Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. , Immunity. , 2004 , 20(2):205-18
18) Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. , Nat Med. , 2004 , 10(1):40-7
19) Advances in NF-kappaB signaling transduction and transcription. , Cell Mol Immunol. , 2004 , 1(6):425-35
20) NF-B Activates IL-6 Expression through cooperation with c-Jun and IL6-AP1 site,But Is Independent of Its IL6- NF B Regulatory site in Autocrine Human Multiple Myeloma Cells. , Cancer Biology and Therapy , 2004 , 3:108-113
21) Co-operative Functions between nuclear factors NF-B and CCAT/enhancer-binding protein-beta(C/EBP)REGULATE THE il-6 Promoter in autocrine human prostate cancer cells. , Prostate , 2004 , 61:354-370
22) The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity. , Cancer Res. , 2003 , 63(9):2046-51
23) Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands. , J Biol Chem. , 2002 , 277(6):3973-8
24) CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma)gene transcription in human monocytic cells. , J.Biol.Chem. , 2001 , 276-23275-23281
25) Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta) , Biochim.Biophys.Acta , 2000 , 1492-163-171
26) Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta). , Biochim Biophys Acta. , 2000 , 1492(1):163-71
27) CCAAT/enhancer-binding protein-beta regulates interferon-induced transcription through a novel element. , J Biol Chem. , 2000 , 275(17):12626-32
28) Regulation of interferon-alpha/beta-stimulated gene expression through the gamma-activated transcriptional element. , Antiviral Res. , 1999 , 40(3):145-53
29) Gamma interferon augments macrophage activation by lipopolysaccharide by two distinct mechanisms, at the signal transduction level and via an autocrine mechanism involving tumor necrosis factor alpha and interleukin-1. , Infect Immun. , 1999 , 67(1):206-12
30) Induction of interferon synthesis and activation of interferon-stimulated genes by liposomal transfection reagents. , J Interferon Cytokine Res. , 1998 , 18(11):947-52
31) Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid. , Mol Cell Biol. , 1998 , 18(11):6493-504
32) The polyoma virus T antigen interferes with interferon-inducible gene expression. , Proc Natl Acad Sci U S A. , 1998 , 95(3):1085-90
33) The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc. , Proc Natl Acad Sci U S A. , 1997 , 94(14):7227-3
34) Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid. , J Biol Chem. , 1997 , 272(15):9742-8
35) Interferon gamma-induced transcription of the murine ISGF3gamma (p48) gene is mediated by novel factors. , Proc Natl Acad Sci U S A. , 1997 , 94(1):103-8
 
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