Faculty Profile
 
  XIAO W. OR Weihua X.
     
Department: School of Life Science
Mailing Address:
School of Life Science,University of Science and Technology of China, 443 Huangshan Rd, Hefei, Anhui, PR China
Postal Code:
230027
Phone:
+86-551-3606294
Fax:
86-551-3600535
Homepage:
http://lstt.ustc.edu.cn/a/gb2312/chengyuanjieshao/2011/0612/1.html
 
       

Research Profile

    Xiao Weihua, professor and Ph.D. supervisor.
In 1985 he graduated from Norman Bethune University of Medical Sciences and in 2002 he obtained master’s degree from Johns Hopkins University, U.S.. From 1985 to 1995, he served as an assistant researcher in applied molecular biology at Changchun Institute of Biological Products; from 1995 to 1998 he served as postdoctoral fellow at the Cancer Research Center, University of Maryland, U.S.; from 1998 to 2004 he served as a researcher at U.S.National Cancer Institute; in October 2004 he went back to China and was appointed as professor at School of Life Sciences, USTC.
Http://ioi.ustc.edu.cn/en/faculty/201007/t20100707_24298.html
 
     
Selected Publications
1) Reduced expression of ΔΝp63α in cervical squamous cell carcinoma. , Clin Invest Med. , 2011 , 34(3):E184.
2) In vivo activity of novel anti-ErbB2 antibody chA21 alone and with Paclitaxel or Trastuzumab in breast and ovarian cancer xenograft models , Cancer Immunol Immunother. , 2011 , 60(3):339-48.
3) Gene associated with retinoid-interferon-induced mortality-19 suppresses growth of lung adenocarcinoma tumor in vitro and in vivo. , Lung Cancer. , 2011 , 72(3):287-93
4) Identification and characterization of GRIM-1, a cell-death-associated gene product. , J Cell Sci. , 2010 , 123(Pt 16):2781-91
5) Transcription factor E2F1 suppresses dendritic cell maturation. , J Immunol. , 2010 , 184(11):6084-91
6) Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. , J Biol Chem. , 2009 , 284(50):34600-6.
7) Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers. , J Interferon Cytokine Res. , 2009 , 29(10):695-703
8) Expression and clinical significance of GRIM-19 in non-small cell lung cancer , Ai Zheng. , 2009 , 28(4):431-5
9) E2F1 induces tumor cell survival via NF-κB-dependent induction of EGR1 transcription in prostate cancer , Cancer Research , 2009 , 2009.69(6);2324-2331
10) 外周血单核细胞来源的树突状细胞成熟过程中Toll样受体的既时表达变化 , 《中华微生物和免疫学杂志》 , 2008 , 2008(7)
11) 转录因子PAX5对多发性骨髓瘤细胞IM9的抗凋亡及促增生作用 , 中国免疫学杂志 , 2008 , 2008(24)
12) 人干扰素α2b和IgG Fc片段融合蛋白显著延长体内半 衰期 , 生物工程学报 , 2008 , 2008年第一期
13) The interferon signaling network and transcription factor C/EBP-beta. , Cell Mol Immunol. , 2007 , 4(6):407-18
14) mRNA secondary structure at start AUG codon is a key limiting factor for human protein expression in Escherichia coli. , Biochem Biophys Res Commun. , 2006 , 349(1):69-78
15) Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis. , Cancer Res. , 2005 , 65(14):6255-63
16) Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. , J Biol Chem. , 2005 , 280(6):4182-7
17) Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. , Immunity. , 2004 , 20(2):205-18
18) Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. , Nat Med. , 2004 , 10(1):40-7
19) Advances in NF-kappaB signaling transduction and transcription. , Cell Mol Immunol. , 2004 , 1(6):425-35
20) NF-B Activates IL-6 Expression through cooperation with c-Jun and IL6-AP1 site,But Is Independent of Its IL6- NF B Regulatory site in Autocrine Human Multiple Myeloma Cells. , Cancer Biology and Therapy , 2004 , 3:108-113
21) Co-operative Functions between nuclear factors NF-B and CCAT/enhancer-binding protein-beta(C/EBP)REGULATE THE il-6 Promoter in autocrine human prostate cancer cells. , Prostate , 2004 , 61:354-370
22) The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity. , Cancer Res. , 2003 , 63(9):2046-51
23) Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands. , J Biol Chem. , 2002 , 277(6):3973-8
24) CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma)gene transcription in human monocytic cells. , J.Biol.Chem. , 2001 , 276-23275-23281
25) Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta) , Biochim.Biophys.Acta , 2000 , 1492-163-171
26) Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta). , Biochim Biophys Acta. , 2000 , 1492(1):163-71
27) CCAAT/enhancer-binding protein-beta regulates interferon-induced transcription through a novel element. , J Biol Chem. , 2000 , 275(17):12626-32
28) Regulation of interferon-alpha/beta-stimulated gene expression through the gamma-activated transcriptional element. , Antiviral Res. , 1999 , 40(3):145-53
29) Gamma interferon augments macrophage activation by lipopolysaccharide by two distinct mechanisms, at the signal transduction level and via an autocrine mechanism involving tumor necrosis factor alpha and interleukin-1. , Infect Immun. , 1999 , 67(1):206-12
30) Induction of interferon synthesis and activation of interferon-stimulated genes by liposomal transfection reagents. , J Interferon Cytokine Res. , 1998 , 18(11):947-52
31) Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid. , Mol Cell Biol. , 1998 , 18(11):6493-504
32) The polyoma virus T antigen interferes with interferon-inducible gene expression. , Proc Natl Acad Sci U S A. , 1998 , 95(3):1085-90
33) The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc. , Proc Natl Acad Sci U S A. , 1997 , 94(14):7227-3
34) Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid. , J Biol Chem. , 1997 , 272(15):9742-8
35) Interferon gamma-induced transcription of the murine ISGF3gamma (p48) gene is mediated by novel factors. , Proc Natl Acad Sci U S A. , 1997 , 94(1):103-8
 
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