Faculty Profile
 
  Qinghua Shi
     
Department: School of Life Science
Mailing Address:
Biology Building, 443 Huangshan Road, Hefei, People's Republic of China
Postal Code:
230027
Phone:
+86-551-63600344
Fax:
86-551-63600344
Homepage:
http://mcg.ustc.edu.cn
 
       

Research Profile

Shi Qinghua, professor and Ph.D. supervisor, is selected into Chinese Academy of Sciences (CAS) Hundred Talents Program and winner of National Natural Science Funds for Distinguished Young Scholars.
In 1998 he graduated from Nanjing Normal University and obtained his Ph.D. degree. From October 1992 to November 1993, as a visiting scholar, he studied at GSF-National Research Center for Environment and Health, Germany. From October 1996 to December 1997, as a jointly trained Ph.D. candidate, he studied at GSF-National Research Center for Environment and Health, Germany, and Nanjing Normal University, China. From November 1998 to December 2001, he served as postdoctoral fellow at University of Calgary, Canada. From January 2002 to December 2004, he served as research fellow at Harvard Medical School, USA. In 2004 he was selected into CAS Hundred Talents Program, and in 2005 he gained the selective support of the CAS Hundred Talents Program. In 2006, he took charge of the projects with important directions of “Knowledge Innovation Program” of CAS. In 2007 he won the support of National Natural Science Founds for Distinguished Young Scholars, and selected to be Research Chair for the national major research project “Molecular Regulation of Follicular Development”. Now he is a Principal Investigator at Hefei National Laboratory for Physical Sciences at Microscale, professor at School of Life Sciences, University of Science and Technology of China (USTC). Over the last decade, he has published more than 30 papers in Nature, American Journal of Human Genetics, Cell Research and other peer-reviewed SCI journals as first or corresponding authors. These papers have been cited about 900 times by colleagues.
 
     
Selected Publications
1) Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. , NATURE , 200510 , 437:1038-1042
2) Lagging chromosomes entrapped in micronuclei are not‘lost’by cells , Cell Research , 201202 , 2012
3) Absence of age effect on meiotic recombination between human X and Y chromosomes , AMERICAN JOURNAL OF HUMAN GENETICS , 2002 , 71(2):254-261
4) Complex relationship between meiotic recombination frequency and autosomal synaptonemal complex length per cell in normal human males , American Journal of Medical Genetics , 201202 , Epub ahead of print
5) Regulation of Asymmetrical Cytokinesis by cAMP during Meiosis I in Mouse Oocytes , Plos One , 201201 , 7(1):e29735
6) p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells , Plos One , 201111 , 6(11):e27304
7) Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines , Chromosome Research , 201110 , 19(7):857-68
8) Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries , PLoS One , 201101 , 6(1):e16046
9) Synapsis and Meiotic Recombination in Male Chinese Muntjac (Muntiacus reevesi) , PLoS One , 201104 , 6(4):e19255
10) Prediction of novel pre-microRNAs with high accuracy through boosting and SVM , Bioinformatics , 201103 , 27(10):1436-1437
11) The fate of micronucleated cells post X-irradiation detected by live cell imaging , DNA Repair (Amst) , 201103 , 10:629-638
12) Micronucleus formation detected by live-cell imaging , Mutagenesis , 201101 , 26(1):133-8
13) Multiple origins of spontaneously arising micronuclei in HeLa cells: Direct evidence from long-term live cell imaging , MUTATION RESEARCH , 200811 , 646(1-2):41-49
14) Abnormal synapsis and recombination in an azoospermic male carrier of a reciprocal translocation t(1;21). , FERTILITY AND STERILITY , 200902 , 91(4):1293 e17-22
15) Cryopreservation has no effect on meiotic recombination and synapsis in testicular tissues , FERTILITY AND STERILITY , 200808 , 91(4):1404-7
16) Cigarette smoking and aneuploidy in human sperm , MOLECULAR REPRODUCTION AND DEVELOPMENT , 200108 , 59(4):417-421
17) Recombination in the pseudoautosomal region in a 47, XYY male , HUMAN GENETICS , 200108 , 109(2):143-145
18) Increased nondisjunction of chromosome 21 with age in human peripheral lymphocytes , MUTATION RESEARCH , 200007 , 452(1):27-36
19) Incidence of mosaic cell lines in vivo and malsegregation of chromosome 21 in lymphocytes in vitro of trisomy 21 patients: detection by fluorescence in situ hybridization on binucleated lymphocytes , HUMAN GENETICS , 200001 , 106(1):29-35
20) Aneuploidy in human spermatozoa: FISH analysis in men with constitutional chromosomal abnormalities, and in infertile men , REPRODUCTION , 200105 , 121(5):655-666
21) Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm , AMERICAN JOURNAL OF MEDICAL GENETICS , 200102 , 99(1):34-38
22) Multicolor fluorescence in situ hybridization analysis of meiotic chromosome segregation in a 47,XYY male and a review of the literature , AMERICAN JOURNAL OF MEDICAL GENETICS , 200007 , 936(1):40-46
23) Spontaneous frequencies of aneuploid and diploid sperm in 10 normal Chinese men: assessed by multicolor fluorescence in situ hybridization , CYTOGENETICS AND CELL GENETICS , 2000 , 90(1-2):79-83
24) Aneuploidy in human sperm: a review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factors , CYTOGENETICS AND CELL GENETICS , 2000 , 90(3-4):219-226
25) The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells , J Clin Invest , 200912 , 119(12):3626-36
26) Comparative proteome profile of immature rat ovary during primordial follicle assembly and development , Proteomics , 200907 , 9(13):3425-34
27) Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity , J Biol Chem , 201006 , 285(25):19060-7
 
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