Faculty Profile
 
  TIAN Zhigang
     
Department: School of Life Science
Mailing Address:
School of Life Science, University of Science and Technology of China, 443 Huangshan Rd, Hefei, Anhui, PR China
Postal Code:
230027
Phone:
+86-551-63600845
Fax:
0551-63600832,0551-63606783
Homepage:
http://ioi.ustc.edu.cn/en/faculty/201007/t20100707_24302.html
 
       

Research Profile

	  
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Selected Publications
1) NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice , Proceedings of National Academy of Science USA , 2007 , 104(18):7512-5.
2) TLR-3 ligand attenuates LPS-induced liver injury by down-regulation of TLR-4 expression on macrophages. , Proceedings of National Academy of Sciences USA , 2005 , 102 (47): 17077-17082.
3) NKG2D-retinoic acid early inducible-1 recognitionbetween natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.. , Hepatology , 2009 , 2009
4) Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. , Hepatology , 2008 , 47:648-58
5) Liver: An organ with predominant innate immunity.Review , Hepatology. , 2008 , 47(2):729-36.
6) Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice. , Hepatology , 2007 , 45(6):1400-12
7) Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. , Hepatology. , 2007 , 46(3):706-15
8) Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. , Hepatology , 2006 , 43(6):1211-9.
9) CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. , J Immunol. , 2008 , 181(10):7221- 9
10) Recognition of double-stranded RNA by Toll-like receptor 3 induces severe small intestinal injury in mice , Journal of Immunology , 2007 , 178(7):4548-56
11) NK3-like NK cells are involved in protective effect of poly I:C on type I diabetes in nonobese diabetic mice , Journal of Immunology , 2007 , 178 (4): 2141-2147
12) Toll-like receptor 9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. , J Immunol , 2009 , 2009
13) Human NK cells positively regulate gammadelta T cells in response to Mycobacterium tuberculosis , Journal of Immunology , 2006 , 176(4):2610-6.
14) Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. , Journal of Hepatology , 2006 , 44(3):446-54.
15) Liver-specific HBsAg transgenic mice are over-sensitive to Poly (I:C)-induced liver injury in NK cell- and IFN--dependent manners. , Journal of Hepatology , 2007 , 47(2):183-90.
16) Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. 23.Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. , Hepatology , 2011 , 53(1):219-29.
17) Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner , Hepatology , 2011 , 54(4):1179-89.
18) LFA-1 and CD2 synergize for the ERK1/2 activation in the NK cell immunological synapse. , J Biol Chem , 2009 , 2009
19) 15.Establishment, Characterization and Successful Adaptive Therapy against Human Tumors of NKG Cell, a New Human NK Cell Line , Cell Transplant. , 2011 , 2011 Jun 7.
20)  Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection , Journal of virology , 2012 , 卷: 86 期: 4 页: 2251-8
21) IFN-γ induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice , J Autoimmun , 2012 , 38(1):20-8.
 
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